Immunoglobulin concentrations and antigen-specific antibody levels in cervicovaginal lavages of rhesus macaques are influenced by the stage of the menstrual cycle

Infection and Immunity

Volumn 67, Issue 12, 1999, Pages 6321-6328

  Lü, F Xusheng ^a,b   Ma, Zhongmin ^a   Rourke, Tracy ^a   Srinivasan, Seema ^a   Mcchesney, Michael ^a   Miller, Christopher J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ESTRADIOL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; PROGESTERONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; FEMALE GENITAL SYSTEM; HORMONAL REGULATION; IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; MENSTRUAL CYCLE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; UTERINE CERVIX CYTOLOGY;

ANIMALS; ANTIBODIES, BACTERIAL; BODY FLUIDS; CERVIX UTERI; CHOLERA TOXIN; FEMALE; HEMOCYANIN; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; MACACA MULATTA; MENSTRUAL CYCLE; RECTUM; TETANUS TOXOID; VAGINA;

EID: 0032743544     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Chipperfield, E. J., and B. A. Evans. 1975. Effect of local infection and oral contraception on immunoglobulin levels in cervical mucus. Infect. Immun. 11:215-221.
2. Fahey, J. V., S. L. Humphrey, J. E. Stern, and C. R. Wira. 1998. Secretory component production by polarized epithelial cells from the human female reproductive tract. Immunol. Investig. 27:167-180.
3. Forrest, B. D. 1991. Women, HIV, and mucosal immunity. Lancet 337:834-835.
4. Fu, Y. S., and J. W. Reagan. 1989. Pathology of the uterine cervix, vagina and vulva, vol. 21. W. B. Saunders, Philadelphia, Pa.
5. Gallichan, W. S., and K. L. Rosenthal. 1996. Effects of the estrous cycle on local humoral immune responses and protection of intranasally immunized female mice against herpes simplex virus type 2 infection in the genital tract. Virology 224:487-497.
6. Gilardi, K. V. K., S. E. Shideler, C. R. Valverde, J. A. Roberts, and B. L. Lasley. 1997. Characterization of the onset of menopause in the rhesus macaque. Biol. Reprod. 57:335-340.
7. Jalanti, R., and H. Isliker. 1977. Immunoglobulins in human cervico-vaginal secretions. Int. Arch. Allergy Appl. Immunol. 53:402-409.
8. Kaushic, C., E. Frauendorf, R. M. Rossoll, J. M. Richardson, and C. R. Wira. 1998. Influence of the estrous cycle on the presence and distribution of immune cells in the rat reproductive tract. Am. J. Reprod. Immunol. 39: 209-216.
9. Kubota, M., C. J. Miller, K. Imaoka, S. Kawabata, K. Fujihashi, J. R. McGhee, and H. Kiyono. 1997. Oral immunization with simian immunodeficiency virus (SIV) p55 gag and cholera toxin elicits both mucosal IgA and systemic immune responses in non-human primates J. Immunol. 158:5321-5329.
10. Kutteh, W. H., S. J. Prince, K. R. Hammond, C. C. Kutteh, and J. Mestecky. 1996. Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation. Clin. Exp. Immunol. 104: 538-542.
11. Lü, X., L. Belec, P. M. V. Martin, and J. Pillot. 1991. Enhanced local immunity in vaginal secretions of HIV-infected women. Lancet 338:323-324.
12. Lü, X., L. Belec, and J. Pillot. 1993. Anti-gp160 IgG and IgA antibodies associated with a large increase in total IgG in cervicovaginal secretions from human immunodeficiency virus type 1-infected women. J. Infect. Dis. 167: 1189-1192.
13. Lü, X. S., and C. J. Miller. 1996. Concentration of IgG in the sera of normal rhesus macaques as determined by a species-specific radial immunodiffusion assay. J. Immunol. Methods 197:193-196.
14. McGhee, J. R., and H. Kiyono. 1992. Mucosal immunity to vaccines: current concepts for vaccine development and immune response analysis, p. 3-12. In J. E. Ciardi (ed.), Genetically engineered vaccines. Plenum Press, New York, N.Y.
15. McGhee, J. R., and J. Mestecky. 1990. In defense of mucosal surfaces: Development of novel vaccines for IgA responses at the portals of entry of microbial pathogens. Infect. Dis. Clin. North Am. 4:315-341.
16. Mestecky, J., and J. R. McGhee. 1987. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv. Immunol. 40:153-245.
17. Miller, C. J., N. J. Alexander, and M. B. McChesney. 1994. Vaccines to prevent sexually transmitted diseases: the challenge of generating protective immunity at genital mucosal surfaces, p. 193-212. In G. L. Ada (ed.), Strategies in vaccine design. R. G. Landes Co., Austin, Tex.
18. Miller, C. J., D. W. Kang, M. Marthas, Z. Moldoveanu, H. Kiyono, P. Max, J. H. Eldridge, J. Mestecky, and J. R. McGhee. 1992. Genital secretory immune responses to chronic SIV infection: a comparison between intravenously and genitally inoculated rhesus macaques. Clin. Exp. Immunol. 88: 520-526.
19. Miller, C. J., M. B. McChesney, X. Lü, P. J. Daily, C. Chutkowski, D. Lu, P. Brosio, B. Roberts, and Y. Lu. 1997. Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239. J. Virol. 71:1911-1921.
20. Monfort, S. L., D. L. Hess, S. E. Shideler, S. J. Sammuels, A. G. Hendrickx, and B. L. Lasley. 1987. Comparison of serum estradiol to urinary estrone conjugates in the rhesus macaque (Macaca mulatta). Biol. Reprod. 37:832-837.
21. Schumacher, G. F. B. 1977. Soluble proteins in cervical mucus, p. 201-233. In V. Insler and G. Bettendorf (ed.), The uterine cervix in reproduction. Georg Thieme Verlag, Stuttgart, Germany.
22. Schumacher, G. F. B., and S. L. Yang. 1977. Cyclic changes of immunoglobulins and specific antibodies in human and rhesus monkey cervical mucus, p. 187-203. In V. Insler, and G. Bettendorf (ed.), The uterine cervix in reproduction. Georg Thieme Verlag, Stuttgart, Germany.
23. Shideler, S. E., C. H. L. Shackleton, F. M. Moran, P. Stauffer, P. N. Lohstroh, and B. L. Lasley. 1993. Enzyme immunoassays for ovarian steroid metabolites in the urine of Macaca fascicularis. J. Med. Primatol. 22:301-312.
24. Taussky, H. H. 1954. A microcolorimetric determination of creatine in urine by the Jaffe reaction. J. Biol. Chem. 208:853-861.
25. Tjokronegoro, A., and S. Sirisinha. 1975. Quantitative analysis of immunoglobulins and albumin in secretion of female reproductive tract. Fertil. Steril. 26:413-417.
26. Usala, S. J., F. O. Usala, R. Haciski, J. A. Holt, and G. F. Schumacher. 1989. IgG and IgA content of vaginal fluid during the menstrual cycle. J. Reprod. Med. 34:292-294.
27. Wira, C. R., C. Kaushic, and J. Richardson. 1999. Role of sex hormones and cytokines in regulating the mucosal immune system in the female reproductive tract, p. 1449-1461. In P. L. Ogra, J. Mestecky, M. Lamm, W. Strober, J. Bienenstock, and J. R. McGhee (ed.), Mucosal immunology, 2nd ed. Academic Press, Inc., San Diego, Calif.
28. Wira, C. R., and C. P. Sandoe. 1977. Sex steroid hormone regulation of IgA and IgG in rat uterine secretions. Nature 268:534-536.
29. Yang, S. L., and G. F. B. Schumacher. 1979. Immune response after vaginal application of antigens in the rhesus monkeys. Fertil. Steril. 32:588-598.
30. Yeaman, G. R., H. D. White, A. Howell, R. Prabhala, and C. R. Wira. 1998. The mucosal immune system in the human female reproductive tract: potential insights into the heterosexual transmission of HIV. AIDS Res. Hum. Retroviruses 14(Suppl. 1):S57-S62.