Beveled fiber-optic probe couples a ball lens for improving depth-resolved fluorescence measurements of layered tissue: Monte Carlo simulations

Physics in Medicine and Biology

Volumn 53, Issue 4, 2008, Pages 937-951

  Jaillon, Franck ^a   Zheng, Wei ^a   Huang, Zhiwei ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; FLUORESCENCE SPECTROSCOPY; LENSES; MONTE CARLO METHODS; TISSUE ENGINEERING;

EPITHELIAL TISSUES; EXCITATION-COLLECTION FIBER SEPARATIONS; FLAT TIP EXCITATION FIBERS; TISSUE LAYERS;

FIBER OPTIC SENSORS;

ARTICLE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; EPITHELIUM; FIBER OPTICS; FLUORESCENCE; HUMAN; MONTE CARLO METHOD; PRIORITY JOURNAL; SIGNAL DETECTION; STROMA;

EPITHELIUM; FIBER OPTICS; FLUORESCENCE; LENSES; MODELS, BIOLOGICAL; MONTE CARLO METHOD; PROTONS;

EID: 39049160479     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/53/4/008     Document Type: Article

References (23)

1. Amelink A, Bard M P L, Burgers S A and Sterenborg H J C M 2003 Single-scattering spectroscopy for the endoscopic analysis of particle size in superficial layers of turbid media Appl. Opt. 42 4095-101
2. Born M and Wolf E 1999 Principles of Optics: Electromagnetic Theory of Propagation, Interference and Diffraction of Light (Cambridge: Cambridge University Press)
3. Chang S K, Arifler D, Drezek R, Follen M and Richards-Kortum R 2004 Analytical model to describe fluorescence spectra of normal and preneoplastic epithelial tissue: comparison with Monte Carlo simulations and clinical measurements J. Biomed. Opt. 9 511-22
4. Drezek R, Sokolov K, Utzinger U, Boiko I, Malpica A, Follen M and Richards-Kortum R 2001 Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: modeling, measurements, and implications J. Biomed. Opt. 6 385-96
5. Ghosh N, Majumder S K, Patel H S and Gupta P K 2005 Depth-resolved fluorescence measurement in a layered turbid medium by polarized fluorescence spectroscopy Opt. Lett. 30 162-4
6. Holstein S V, Nilsson C, Andersson-Engels S, Willen R, Walther B and Svanberg K 1996 Detection of adenomacarcinoma in Barretts's esophagus by means of laser induced fluorescence Gut. 39 711-6
7. Huang Z, Zeng H, Hamzavi I, McLean D I and Lui H 2001 Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements Opt. Lett. 26 1782-4
8. Huang Z, Zheng W, Xie S, Chen R, Zeng H, McLean D I and Lui H 2004 Laser-induced autofluorescence microscopy of normal and tumor human colonic tissue Int. J. Oncol. 24 59-64
9. Hung J, Lam S, LeRiche J C and Palcic B 1991 Autofluorescence of normal and malignant bronchial tissue Lasers Surg. Med. 59 930-3
10. Hyde D E, Farrell T J, Patterson M S and Wilson B C 2001 A diffusion theory model of spatially resolved fluorescence from depth- dependent fluorophore concentrations Phys. Med. Biol. 46 369-83
11. Liu Q and Ramanujam N 2002 Relationship between depth of a target in a turbid medium and fluorescence measured by a variable-aperture method Opt. Lett. 27 104-6
12. Liu Q and Ramanujam N 2004 Experimental proof of the feasibility of using an angled fiber-optic probe for depth-sensitive fluorescence spectroscopy of turbid media Opt. Lett. 29 2024-6
13. Nieman L, Myakov A, Aaron J and Sokolov K 2004 Optical sectioning using a fiber probe with an angled excitation-collection geometry: evaluation in engineered tissue phantoms Appl. Opt. 43 1308-19
14. Pfefer T J, Matchette L S, Ross A M and Ediger M N 2003 Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design Opt. Lett. 28 120-2
15. Pfefer T J, Schomacker K T, Ediger M N and Nishioka N S 2002 Multiple-fiber probe design for fluorescence spectroscopy in tissue Appl. Opt. 41 4712-21
16. Pogue B W and Burke G 1998 Fiber-optic bundle design for quantitative fluorescence measurement from tissue Appl. Opt. 37 7429-36
17. Schwarz R A, Arifler D, Chang S K, Pavlova I, Hussain I A, Mack V, Knight B, Richards-Kortum R and Gillenwater A M 2005 Ball lens coupled fiber-optic probe for depth-resolved spectroscopy of epithelial tissue Opt. Lett. 30 1159-61
18. Skala M C, Palmer G M, Zhu C F, Liu Q, Vrotsos K M, Marshek-Stone C L, Gendron-Fitzpatrick A and Ramanujam N 2004 Investigation of fiber-optic probe designs for optical spectroscopic diagnosis of epithelial pre-cancers Lasers Surg. Med. 34 25-38
19. Utzinger U and Richards-Kortum R 2003 Fiber optic probes for biomedical optical spectroscopy J. Biomed. Opt. 8 121-47
20. Vishwanath K, Pogue B and Mycek M A 2002 Quantitative fluorescence lifetime spectroscopy in turbid media: comparison of theoretical, experimental and computational methods Phys. Med. Biol. 47 3387-405
21. Vishwanath K and Mycek M A 2004 Do fluorescence decays remitted from tissues accurately reflect intrinsic fluorophores lifetimes? Opt. Lett. 29 1512-4
22. Wang L, Jacques S L and Zheng L 1995 MCML-Monte Carlo modeling of light transport in multi-layered tissues Comput. Methods Programs Biomed. 47 131-46
23. Zhu C F, Liu Q and Ramanujam N 2003 Effect of fiber optic probe geometry on depth-resolved fluorescence measurements from epithelial tissues: a Monte Carlo simulation J. Biomed. Opt. 8 237-47