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Guarantor of the article: Nimish Vakil, M.D. Financial support: Consultant for Astra-Zeneca, Orexo, Novartis, Shire, TAP, Proctor and Gamble, XenoPort, Ortho-MacNeil; Speaker's Bureau for Novartis, Takeda, Astra-Zeneca, TAP, XenoPort, AGI; Gravit/Research support from Astra-Zeneca, Novartis, Boston-Scientific, Medtronics, Altana; Stock shareholder of Orexo. Potential competing interests: None.
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