Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice

Scandinavian Journal of Gastroenterology

Volumn 32, Issue 10, 1997, Pages 965-973

  Venables, T L ^a   Newland, R D ^b   Patel, A C ^b   Hole, J ^b   Wilcock, C ^b   Turbitt, M L ^b  

^a Surgery   (United Kingdom)

^b NONE

Author keywords

Gastro esophageal reflux disease; General practice; Omeprazole; Ranitidine; Reflux oesophagitis

Indexed keywords

OMEPRAZOLE; RANITIDINE;

ADULT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; ENDOSCOPY; ESOPHAGITIS; FEMALE; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SYMPTOMATOLOGY; TREATMENT OUTCOME;

EID: 0030862096     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365529709011211     Document Type: Article

References (17)

1. Heading RC. Epidemiology of oesophageal reflux disease. Scand J Gastroenterol 1989;24 Suppl 168:33-7.
2. Heartburn self-treated. Chemist Druggist 1989;232(Pt 5703): 856.
3. Ruth M, Ehnbom H, Lundell L, Lonorth H, Sandberg N, Sandmark S. The effect of omeprazole or ranitidine on 24 hour oesophageal acidity in patients with reflux oesophagitis. Scand J Gastroenterol 1988;23:1141-6.
4. 2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: a metaanalysis. Eur J Gastroenterol Hepatol 1995;7:467-75.
5. Bell N, Hunt RH. Role of gastric acid suppression in the treatment of gastro-oesophageal reflux disease. Gut 1992;33:118-24.
6. Hungin AP, Gunn SD, Bate CM, Turbitt ML, Wilcock C, Richardson PDI. A comparison of the efficacy of omeprazole 20mg once daily with ranitidine 150mg bd in the relief of symptomatic gastro-oesophageal reflux disease in general practice. Br J Clin Res 1993;4:73-88.
7. Robinson M, Maton PN, Allen ML, Humphries TJ, McIntosh D, Cagliola AJ, et al. The effect of different doses of omeprazole on 24 hour oesophageal acid exposure in patients with gastroesophageal reflux. Aliment Pharmacol Ther 1991;5:645-61.
8. Bate CM, Booth SN, Crowe JP, Mountford RA, Keeling PWN, Hepworth-Jones B, et al. Omeprazole 10mg or 20mg once daily in the prevention of recurrence of reflux oesophagitis. Gut 1995;36:492-8.
9. Hallerback B, Unge P, Carling L, Edwin B, Glise H, Havu N, et al. Omeprazole or ranitidine in long-term treatment of reflux oesophagitis. Gastroenterology 1995;107:1305-11.
10. Green JRB. Is there such an entity as mild oesophagitis? Eur J Clin Res 1993;4:29-34.
11. Joelsson B, Johnsson F. Heartburn - the acid test. Gut 1989;30: 1523-5.
12. Ollyo J-B, Lang F, Fontolliet C, Monnier P. Savary-Miller's new reproducible, logical, complete and useful classification. Gastroenterology 1990;98:A 100.
13. Bramble MG, Cooke WM, Corbett WA, Cann PA, Clarke D, Contractor B, et al. Organising unrestricted open access gastroscopy in South Tees. Gut 1993;34:422-7.
14. Bate CM, Crowe JP, Dickinson RJ, Green JRB, Banarjee S, Dronfield MW, et al. Reflux oesophagitis resolves more rapidly with omeprazole 20mg once daily than with ranitidine 150mg twice daily: omeprazole 40mg once daily provides further benefit in unresponsive patients. Br J Clin Res 1991;2:133-48.
15. Dent J, Watts R, Riley S, Shiekh R, de Groot G, van Oudvorst A, et al. Gastro-oesophageal reflux disease in primary care: an international placebo controlled study of different treatment strategies with omeprazole. Gastroenterology 1996:110:A93.
16. Bate CM, Griffin SM, Keeling PWN, Axon ATR, Dronfield MW, Chapman RWG, et al. Reflux symptom relief with omeprazole in patients without unequivocal oesophagitis. Aliment Pharmacol Ther 1996;10:547-55.
17. Holt S, Howden CW. Omeprazole: overview and opinion. Dig Dis Sci 1991;36:385-93.