Expression of aromatase and estrogen sulfotransferase in eutopic and ectopic endometrium: Evidence for unbalanced estradiol production in endometriosis

Reproductive Sciences

Volumn 14, Issue 8, 2007, Pages 798-805

  Hudelist, G ^a,b   Czerwenka, K ^a   Keckstein, J ^b   Haas, C ^a   Fink Retter, A ^a   Gschwantler Kaulich, D ^a   Kubista, E ^a   Singer, C F ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b LKH Villach ^*  (Austria)

Author keywords

Aromatase; Autonomous E2 production; Endometriosis; Estrogen sulfotransferase

Indexed keywords

AROMATASE; ESTRADIOL; ESTROGEN SULFOTRANSFERASE; ESTRONE SULFOTRANSFERASE; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ECTOPIC ORGAN; ENDOMETRIOSIS; ESTROGEN SYNTHESIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; BIOPSY; BIOSYNTHESIS; ENZYMOLOGY; METABOLISM;

ADULT; AROMATASE; BIOPSY; ENDOMETRIOSIS; ESTRADIOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; SULFOTRANSFERASES;

EID: 39049110724     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719107309120     Document Type: Article

References (32)

1. Melis GB, Ajossa S., Guerriero S., et al. Epidemiology and diagnosis of endometriosis. Ann N Y Acad Sci. 1994 ; 734: 352-357.
2. Kjerulff KH, Erickson BA, Langenberg PW Chronic gynecological conditions reported by US women: findings from the National Health Interview Survey, 1984 to 1992. Am J Public Health. 1996 ; 86 (2). 195-199.
3. Vignali M., Infantino M., Matrone R., et al. Endometriosis: novel etiopathogenetic concepts and clinical perspectives. Fertil Steril. 2002 ; 78 (4). 665-678.
4. Valle RF Endometriosis: current concepts and therapy. Int J Gynaecol Obstet. 2002 ; 78 (2). 107-119.
5. Waller KG, Shaw RW Gonadotropin-releasing hormone analogues for the treatment of endometriosis: long-term follow-up. Fertil Steril. 1993 ; 59 (3). 511-515.
6. Bulun SE, Zeitoun KM, Takayama K., Sasano H. Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance. J Mol Endocrinol. 2000 ; 25 (1). 35-42.
7. Kitawaki J., Noguchi T., Amatsu T., et al. Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium. Biol Reprod. 1997 ; 57 (3). 514-519.
8. Matsuzaki S., Canis M., Pouly JL, Dechelotte PJ, Mage G. Analysis of aromatase and 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection. Fertil Steril. 2006 ; 85 (2). 308-313.
9. Attar E., Bulun SE Aromatase and other steroidogenic genes in endometriosis: translational aspects. Hum Reprod Update. 2006 ; 12 (1). 49-56.
10. Bulun SE, Gurates B., Fang Z., et al. Mechanisms of excessive estrogen formation in endometriosis. J Reprod Immunol. 2002 ; 55 (1-2). 21-33.
11. Abul-Hajj YJ, Iverson R., Kiang DT Aromatization of androgens by human breast cancer. Steroids. 1979 ; 33 (2). 205-222.
12. Lipton A., Santner SJ, Santen RJ, et al. Aromatase activity in primary and metastatic human breast cancer. Cancer. 1987 ; 59 (4). 779-782.
13. Suzuki T., Miki Y., Nakamura Y., et al. Sex steroid-producing enzymes in human breast cancer. Endocr Relat Cancer. 2005 ; 12 (4). 701-720.
14. Zhang H., Varlamova O., Vargas FM, Falany CN, Leyh TS Sulfuryl transfer: the catalytic mechanism of human estrogen sulfotransferase. J Biol Chem. 1998 ; 273 (18). 10888-10892.
15. Geisler J. Breast cancer tissue estrogens and their manipulation with aromatase inhibitors and inactivators. J Steroid Biochem Mol Biol. 2003 ; 86 (3-5). 245-253.
16. Geisler J., Lonning PE Aromatase inhibition: translation into a successful therapeutic approach. Clin Cancer Res. 2005 ; 11 (8). 2809-2821.
17. Bulun SE, Zeitoun K., Takayama K., et al. Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis. Endocr Relat Cancer. 1999 ; 6 (2). 293-301.
18. Zeitoun KM, Bulun SE Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target. Fertil Steril. 1999 ; 72 (6). 961-969.
19. Rock JA The revised American Fertility Society classification of endometriosis: reproducibility of scoring. ZOLADEX Endometriosis Study Group. Fertil Steril. 1995 ; 63 (5). 1108-1110.
20. Sasano H., Frost AR, Saitoh R., et al. Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma. J Clin Endocrinol Metab. 1996 ; 81 (11). 4042-4046.
21. Sasano H., Nagura H., Harada N., Goukon Y., Kimura M. Immunolocalization of aromatase and other steroidogenic
22. enzymes in human breast disorders. Hum Pathol. 1994 ; 25 (5). 530-535.
23. Singer CF, Fink-Retter A., Gschwantler-Kaulich D., et al. Selective spatial up-regulation of intratumoral stromal aromatase in breast cancer patients: evidence for imbalance of local estrogen metabolism. Endocr Relat Cancer. 2006 ; 13 (4). 1101-1107.
24. Remmele W., Stegner HE Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue [in German]. Pathologe. 1987 ; 8 (3). 138-140.
25. Bulun SE, Lin Z., Imir G., et al. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Pharmacol Rev. 2005 ; 57 (3). 359-383.
26. Bulun SE, Fang Z., Imir G., et al. Aromatase and endometriosis. Semin Reprod Med. 2004 ; 22 (1). 45-50.
27. Maia H., Pimentel K., Casoy J., et al. Aromatase expression in the eutopic endometrium of myomatous uteri: the influence of the menstrual cycle and oral contraceptive use. Gynecol Endocrinol. 2007 ; 23 (6). 320-324.
28. Watanabe K., Sasano H., Harada N., et al. Aromatase in human endometrial carcinoma and hyperplasia: immunohistochemical, in situ hybridization, and biochemical studies. Am J Pathol. 1995 ; 146 (2). 491-500.
29. Heilier JF, Donnez O., Van Kerckhove V., Lison D., Donnez J. Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum. Fertil Steril. 2006 ; 85 (5). 1516-1518.
30. Falany JL, Falany CN Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone. Endocrinology. 1996 ; 137 (4). 1395-1401.
31. Hata H., Holinka CF, Pahuja SL, Hochberg RB, Kuramoto H., Gurpide E. Estradiol metabolism in Ishikawa endometrial cancer cells. J Steroid Biochem. 1987 ; 26 (6). 699-704.
32. Zeitoun K., Takayama K., Sasano H., et al. Deficient 17beta- hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol. J Clin Endocrinol Metab. 1998 ; 83 (12). 4474-4480.