Oxalate exposure provokes HSP 70 response in LLC-PK1 cells, a line of renal epithelial cells: Protective role of HSP 70 against oxalate toxicity

Urological Research

Volumn 36, Issue 1, 2008, Pages 1-10

  Koul, Sweaty ^a   Huang, Meiyi ^a   Bhat, Sidarth ^a   Maroni, Paul ^a   Meacham, Randall B ^a   Koul, Hari K ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Gene expression; Heat shock protein; Immediate early genes; LLC PK1 cells; Nephrolithiasis; Oxalate toxicity

Indexed keywords

HEAT SHOCK PROTEIN 70; MESSENGER RNA; MYC PROTEIN; OXALIC ACID; PROTEIN C JUN; THYMIDINE; TRITIUM; URIDINE;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; KIDNEY EPITHELIUM; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENAL PROTECTION; RNA SYNTHESIS; WESTERN BLOTTING;

ANIMALS; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, IMMEDIATE-EARLY; HSP70 HEAT-SHOCK PROTEINS; KIDNEY TUBULES, PROXIMAL; MODELS, ANIMAL; OXALATES; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; RNA, MESSENGER; SWINE;

EID: 39049110052     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00240-007-0130-4     Document Type: Article

References (48)

1. Ananthan J, Goldberg AL, Voellmy R (1986) Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes. Science 232:522-524
2. Ang D, Liberek K, Skowyra D, Zylicz M, Georgopoulos C (1991) Biological role and regulation of the universally conserved heat shock proteins. J Biol Chem 266:24233-24236
3. Baler R, Welch WJ, Voellmy R (1992) Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor. J Cell Biol 117:1151-1159
4. Beckmann RP, Mizzen LE, Welch WJ (1990) Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly. Science 248:850-854
5. Capasso JM, Rivard JC, Berl T (2001) Long-term adaptation of renal cells to hypertonicity: role of MAP kinases and Na-K-ATPase. Am J Physiol Renal Physiol 280(5):F768-F776
6. Cajone F, Salina M, Bernelli-Zazzera A (1988) C-myc gene expression in heat-adapted and heat-shocked cells. Cell Biol Int Rep 12:549-553
7. Chaturvedi L, Koul S, Sekhon A, Bhandari A, Menon M, Koul H (2002) Oxalate selectively activates p38 mitogen-activated protein kinase and c-Jun N-terminal kinase signal transduction pathways in renal epithelial cells. J Biol Chem 277(15):13321-13330
8. Chomczynski P, Sacchi N (1994) Guanidine methods for total RNA preparation. In: Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds) Current protocol in molecular biology. Wiley, New York, pp 4.2.1-4.2.2
9. Cohen DM, Wasserman JC, Gullans SR (1991) Immediate early gene and HSP70 expression in hyperosmotic stress in MDCK cells. Am J Physiol 261:C594-C601
10. Cohen DM, Gullans SR (1993) Urea selectively induces DNA synthesis in renal epithelial cells. Am J Physiol 264:F601-F607
11. Hackett RL, Khan SR (1988) Presence of calcium oxalate crystals in the mammalian thyroid gland. Scanning Microsc 2:241-246
12. Hammes MS, Lieske JC, Pawar S, Spargo BH, Toback FG (1995) Calcium oxalate monohydrate crystals stimulate gene expression in renal epithelial cells. Kidney Int 48:501-509
13. Hightower LE (1991) Heat shock, stress proteins, chaperones, and proteotoxicity. Cell 66:191-197
14. Koul H, Huang M (2003) Oxalate exposure provokes the immediate early genes (c-myc and c-jun) and HSP70 response in LLC-PK1 cells, a line of renal epithelial cells. J Am Soc Nephrol 14:abstract# SO-PO760
15. Huang MY, Chaturvedi LS, Koul S, Koul HK (2005) Oxalate stimulates IL-6 production in HK-2 cells, a line of human renal proximal tubular epithelial cells. Kidney Int 68(2):497-503
16. Iida S, Peck AB, Byer KJ, Khan SR (1999) Expression of bikunin mRNA in renal epithelial cells after oxalate exposure. J Urol 162:1480-1486
17. Johnson PF, McKnight SL (1989) Eukaryotic transcriptional regulatory proteins. Annu Rev Biochem 58:799-839
18. Kao HT, Capasso O, Heintz N, Nevins JR (1985) Cell cycle control of the human HSP70 gene: implications for the role of a cellular E1A-like function. Mol Cell Biol 5:628-633
19. Kelly K, Cochran BH, Stiles CD, Leder P (1983) Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35:603-610
20. Khan SR (1995) Calcium oxalate crystal interaction with renal tubular epithelium, mechanism of crystal adhesion and its impact on stone development. Urol Res 23:71-79
21. Khan SR, Thamilselvan S (2000) Nephrolithiasis: a consequence of renal epithelial cell exposure to oxalate and calcium oxalate crystals. Mol Urol 4:305-312
22. Kingston RE, Baldwin AS Jr, Sharp PA (1984) Regulation of heat shock protein 70 gene expression by c-myc. Nature 312:280-282
23. Knight TF, Senekjian HO, Taylor K, Steplock DA, Weinman EJ (1979) Renal transport of oxalate: effects of diuretics, uric acid, and calcium. Kidney Int 16:572-576
24. Kohjimoto Y, Honeyman TW, Jonassen J, Gravel K, Kennington L, Scheid CR (2000) Phospholipase A2 mediates immediate early genes in cultured renal epithelial cells: possible role of lysophospholipid. Kidney Int 58:638-646
25. Koul H, Menon M, Scheid C (1996) Oxalate and renal tubular cells: a complex interaction. Ital J Miner Electrolyte Metab 10:67-74
26. 2K update. In: Proceedings of the international CME in urology, pp 89-97
27. Koul H, Ebisuno S, Renzulli L, Yanagawa M, Menon M, Scheid C (1994) Polarized distribution of oxalate transport systems in LLC-PK1 cells, a line of renal epithelial cells. Am J Physiol 266:F266-F274
28. Koul H, Kennington L, Nair G, Honeyman T, Menon M, Scheid C (1994) Oxalate-induced initiation of DNA synthesis in LLC-PK1 cells, a line of renal epithelial cells. Biochem Biophys Res Commun 205:1632-1637
29. Koul H, Menon M, Chaturvedi L, Koul S, Sekhon A, Bhandari A, Haung M (2002) Activation of the p38-MAP kinase signal transduction pathways by COM-crystals. J Biol Chem 277(39):36845-36852
30. Koul S, Chaturved LS, Sekhon A, Bhandari A, Menon M, Koul HK (2002) Effect of oxalate on the re-initiation of DNA synthesis in LLC-PK1 cells do not involve p42/44 MAP kinase activation. Kidney Int 61:525-533
31. Kuo SM, Aronson PS (1996) Pathways for oxalate transport in rabbit renal microvillus membrane vesicles. J Biol Chem 271:15491-15497
32. Lieske JC, Hammes MS, Hoyer JR, Toback FG (1997) Renal cell osteopontin production is stimulated by calcium oxalate monohydrate crystals. Kidney Int 51:679-686
33. Lindquist S, Craig EA (1988) The heat-shock proteins. Annu Rev Genet 22:631-677
34. Milarski KL, Morimoto RI (1986) Expression of human HSP70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci USA 83:9517-9521
35. Misfeldt DS, Sanders MJ (1981) Transepithelial transport in cell culture: d-glucose transport by a pig kidney cell line (LLC-PK1). J Membr Biol 59:13-18
36. Ono K, Yasukohchi A, Kikawa K (1987) Pathogenesis of acquired renal cysts in hemodialysis patients. The role of oxalate crystal deposition in renal tubules. ASAIO Trans 33:245-249
37. Radi MJ (1989) Calcium oxalate crystals in breast biopsies. An overlooked form of microcalcification associated with benign breast disease. Arch Pathol Lab Med 113:1367-1369
38. Rangnekar VM, Aplin AC, Sukhatme VP (1990) The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein. Nucleic Acids Res 18:2749-2757
39. Robertson WG, Peacock M, Heyburn PJ, Marshall RW, Rutherford A, Williams RE, Clark PB (1979) The significance of mild hyperoxaluria in calcium stone-formation. In: Rose GA, Robertson WG, Watts REW (eds) Oxalate in human biochemistry and clinical pathology. The Welcome Foundation Ltd, London, p 173
40. Ryseck RP, Hirai SI, Yaniv M, Bravo R (1988) Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts. Nature 334:535-537
41. Scheid C, Koul H, Hill WA, Luber-Narod J, Kennington L, Honeyman T, Jonassen J, Menon M (1996) Oxalate toxicity in LLC-PK1 cells: role of free radicals. Kidney Int 49:413-419
42. Sheikh-Hamad D, Garcia-Perez A, Ferraris JD, Peters EM, Burg MB (1994) Induction of gene expression by heat shock versus osmotic stress. Am J Physiol 267:F28-F34
43. Sorger PK (1991) Heat shock factor and the heat shock response. Cell 65:363-366
44. Truong LD, Cartwright J Jr, Alpert L (1992) Calcium oxalate in breast lesions biopsied for calcification detected in screening mammography: incidence and clinical significance. Mod Pathol 5:146-152
45. Welch WJ (1991) The role of heat-shock proteins as molecular chaperones. Curr Opin Cell Biol 3:1033-1038
46. Welch WJ, Kang HS, Beckmann RP, Mizzen LA (1991) Response of mammalian cells to metabolic stress; changes in cell physiology and structure/function of stress proteins. Curr Top Microbiol Immunol 167:31-55
47. Wu BJ, Morimoto RI (1985) Transcription of the human hsp70 gene is induced by serum stimulation. Proc Natl Acad Sci USA 82:6070-6074
48. Wu BJ, Kingston RE, Morimoto RI (1986) Human HSP70 promoter contains at least two distinct regulatory domains. Proc Natl Acad Sci USA 83:629-633