Oxalate stimulates IL-6 production in HK-2 cells, a line of human renal proximal tubular epithelial cells

Kidney International

Volumn 68, Issue 2, 2005, Pages 497-503

  Huang, Mei Yi ^a   Chaturvedi, Lakshmi S ^b   Koul, Sweaty ^d   Koul, Hari K ^c  

^a HENRY FORD HEALTH SCIENCES CENTER   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d NONE

Author keywords

Hyperoxaluria; Interleukin 6; Proinflammatory cytokines; Urolithiasis

Indexed keywords

INTERLEUKIN 6; OXALIC ACID; LIPOPOLYSACCHARIDE; MESSENGER RNA; OXALIC ACID DERIVATIVE;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STUDENT T TEST; UROLITHIASIS; CELL LINE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION; GENETICS; HYPEROXALURIA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION; UPREGULATION;

CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; HYPEROXALURIA; INTERLEUKIN-6; KIDNEY TUBULES, PROXIMAL; LIPOPOLYSACCHARIDES; OXALATES; RNA, MESSENGER; UP-REGULATION; URINARY CALCULI;

EID: 26944493095     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2005.00427.x     Document Type: Article

References (38)

1. KNIGHT TF, SENEKJIAN HO, TAYLOR K, et al: Renal transport of oxalate: Effects of diuretics, uric acid, and calcium. Kidney Int 16:572-576, 1979
2. KOUL H, EBISUNO S, RENZULLI L, et al: Polarized distribution of oxalate transport systems in LLC-PK1 cells, a line of renal epithelial cells. Am J Physiol Renal Physiol 266: F266-F274, 1994
3. KUO MS, ARONSON P: Pathways for oxalate transport in rabbit renal microvillus membrane vesicles. J Biol Chem 271:15491-15497, 1996
4. MENON M, KOUL H: Calcium oxalate nephrolithiasis. J Clin Endocrinol Metab 74:703-707, 1992
5. HACKETT RL, KHAN SR: Presence of calcium oxalate crystals in the mammalian thyroid gland. Scanning Microsc 2:241-246, 1988
6. RADI MJ: Calcium oxalate crystals in breast biopsies. An overlooked form of microcalcification associated with benign breast disease. Arch Pathol Lab Med 113:1367-1369, 1989
7. TRUONG LD, CARTWRIGHT J, JR., ALPERT L: Calcium oxalate in breast lesions biopsied for calcification detected in screening mammography: Incidence and clinical significance. Mod Pathol 5:146-152, 1992
8. HUGHSON MD, BUCHWALD D, FOX M: Renal neoplasia and acquired cystic kidney disease in patients receiving long-term dialysis. Arch Pathol Lab Med 110:592-601, 1986
9. KOUL H, MENON M, SCHEID C: Oxalate and renal tubular cells: A complex interaction. Ital J Mineral and Electrolyte Metab 10:67-74, 1996
10. KOUL H, RENZULLI L, NAIR G, et al: Oxalate-induced initiation of DNA synthesis in LLC-PK1 cells, a line of renal epithelial cells. Biochem Biophys Res Commun 205:1632-1637, 1994
11. KOUL H, KENNINGTON L, JONASSEN J, et al: Activation of c-myc gene mediates the mitogenic effects of oxalate in LLC-PK1 cells, a line of renal epithelial cells. Kidney Int 50:1525-1530, 1996
12. KOUL HK, KOUL S, FU S, et al: Oxalate: From crystal formation to crystal retention. J Am Soc Nephrol 10:8417-8421, 1999
13. KHAN SR, BYER KJ, THAMILSELVAN S, et al: Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells. J Am Soc Nephol 10:S457-S463, 1999
14. CHATURVEDI L, KOUL S, SEKHON A, et al: Oxalate selectively activates p38 mitogen-activated protein kinase and c-Jun N-terminal kinase signal transduction pathways in renal epithelial cells. J Biol Chem 277:13321-13330, 2002
15. KOUL S, CHATURVEDI LS, SEKHON A, et al: Effects of oxalate on the reinitiation of DNA synthesis in LLC-PK1 cells do not involve p42/44 MAP kinase activation. Kidney Int 61:525-533, 2002
16. WIESSNER JH, HASEGAWA AT, HUNG LY, MANDEL NS: Oxalate-induced exposure of phosphatidylserine on the surface of renal epithelial cells in culture. J Am Soc Nephrol 10(Suppl 14):S441-445, 1999
17. BHANDARI A, KOUL S, SEKHON A, et al: Effects of oxalate on HK-2 cells, a line of proximal tubular epithelial cells from normal human kidney. J Urol 168:253-259, 2002
18. ROVIN BH, PHAN LT: Chemotactic factors and renal inflammation. Am J Kidney Dis 31:1065-1084, 1998
19. DAHA MR, VAN KOOTEN C: Is the proximal tubular cell a proinflammatory cell? Nephrol Dial Transplant 15(Suppl 6):41-43, 2000
20. HIRANO T: Interleukin 6 and its receptor: Ten years later. Int Rev Immunol 16:249-284, 1998
21. BOSWELL RN, YARD BA, SCHRAMA E, et al: Interleukin 6 production by human proximal tubular epithelial cells in vitro: Analysis of the effects of interleukin-1 alpha (IL-1 alpha) and other cytokines. Nephrol Dial Transplant 9:599-606, 1994
22. LEONARD M, RYAN MP, WATSON AJ, et al: Role of MAP kinase pathways in mediating IL-6 production in human primary mesangial and proximal tubular cells. Kidney Int 56:1366-77, 1999
23. LOTZ M, VILLIGER P, HUGLI T, et al: Interleukin-6 and interstitial cystitis. J Urol 152:869-873, 1994
24. HEDGES S, ANDERSON P, LIDIN-JANSON G, et al: Interleukin-6 response to deliberate colonization of the human urinary tract with gram-negative bacteria. Infect Immun 59:421-427, 1991
25. HEDGES S, STENQVIST K, LIDIN-JANSON G, et al: Comparison of urine and serum concentrations of interleukin-6 in women with acute pyelonephritis or asymptomatic bacteriuria. J Infect Dis 166:653-656, 1992
26. HIRANO T: Interleukin-6, in The Cytokine Handbook, edited byThomson AW, San Diego, Academic Press, Inc., 1994, pp 145-168
27. RHEE E, SANTIAGO L, PARK E, et al: Urinary IL-6 is elevated in patients with urolithiasis. J Urol 160:2284-2288, 1998
28. CHOMCZYNSKI P, SACCHI N: Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
29. AKIRA S, TAGA T, KISHIMOTO T: Interleukin-6 in biology and medicine. Adv Immunol 54:1-78, 1993
30. FUKATSU A, MATSUO S, TAMAI H: Distribution of interleukin-6 in normal and diseased human kidney. Lab Invest 65:61-66, 1991
31. HORII Y, MURAGUCHI A, IWANO M, et al: Involvement of IL-6 in mesangial proliferative glomerulonephritis. J Immunol 143:3949-3955, 1989
32. RUEF C, BUDDE K, LACY J, et al: Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney Int 38:249-257, 1990
33. HEDGES S, SVENSSON M, SVANBORG C: Interleukin-6 response of epithelial cell lines to bacterial stimulation in vitro. Infect Immun 60:1295-1301, 1992
34. EVAN AP, LINGEMAN JE, COE FL, et al: Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. J Clin Invest 111:607-616, 2003
35. MANDEL N: Mechanism of stone formation. Semin Nephrol 16:364-374, 1996
36. COE FL, KAVALACH AG: Hypercalciuria and hyperuricosuria in patients with calcium nephrolithiasis. N Engl J Med 291:1344-1350, 1974
37. WEISINGER JR, ALONZO E, BELLORIN-FONT E, et al: Possible role of cytokines on the bone mineral loss in idiopathic hypercalciuria. Kidney Int 49:244-250, 1996
38. MISAEL DA SILVA AM, DOS REIS LM, PEREIRA RC, et al: Bone involvement in idiopathic hypercalciuria. Clin Nephrol 57:183-191, 2002