Effects of medroxyprogesterone acetate on cerebral oedema and spatial learning performance after traumatic brain injury in rats

Brain Injury

Volumn 22, Issue 2, 2008, Pages 107-113

  Wright, David W ^a   Hoffman, Stuart W ^a   Virmani, Sharad ^a   Stein, Donald G ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Intervention; Psychopharmacology; Trauma; Traumatic brain injury

Indexed keywords

GESTAGEN; MEDROXYPROGESTERONE ACETATE; PROGESTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN EDEMA; CLINICAL PRACTICE; CONTROLLED STUDY; DRUG EFFICACY; EXPERIMENTAL RAT; FRONTAL CORTEX; HORMONE SUBSTITUTION; LEARNING; MALE; NONHUMAN; RAT; TRAUMATIC BRAIN INJURY;

EID: 39049104214     PISSN: 02699052     EISSN: 1362301X     Source Type: Journal    
DOI: 10.1080/02699050701867399     Document Type: Article

References (32)

1. Roof, RL and Hall, ED (2000) Gender differences in acute cns trauma and stroke: Neuroprotective effects of estrogen and progesterone. Journal of Neurotrauma, 17, pp. 367-388.
2. Schumacher, M., Guennoun, R., Ghoumari, A., Massaad, C., Robert, F., El-Etr, M., Akwa, Y., Rajkowski, K. and Baulieu, EE (2007) Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system. Endocrinology Review, 28, pp. 387-439.
3. Schumacher, M., Guennoun, R. and Stein, DG (2007) Progesterone: therapeutic opportunities for neuroprotection and myelin repair. Pharmacology and Therapeutics, 116, pp. 77-107.
4. Stein, DG (2007) Progesterone exerts neuroprotective effects after brain injury. Brain Research
5. Stein, DG (2006) Progesterone in the experimental treatment of peripheral and central nervous system injuries. Future Neurology, 1, pp. 429-438.
6. Thomas, T., Rhodin, J., Clark, L. and Garces, A. (2003) Progestins initiate adverse events of menopausal estrogen therapy. Climacteric, 6, pp. 293-301.
7. Viscoli, CM, Brass, LM, Kernan, WN, Sarrel, PM, Suissa, S. and Horwitz, RI (2001) A clinical trial of estrogen-replacement therapy after ischemic stroke. New England Journal of Medicine, 345, pp. 1243-1249.
8. Rossouw, JE, Anderson, GL, Prentice, RL, Lacroix, AZ, Kooperberg, C., Stefanick, ML, Jackson, RD, Beresford, SA, Howard, BV and Johnson, KC (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the women's health initiative randomized controlled trial. JAMA, 288, pp. 321-333.
9. Singh, M. (2007) Progestins and neuroprotection: Are all progestins created equal?. Minerva Endocrinology, 32, pp. 95-102.
10. Hapgood, JP, Koubovec, D., Louw, A. and Africander, D. (2004) Not all progestins are the same: Implications for usage. Trends in Pharmacology Science, 25, pp. 554-557.
11. Kuhl, H. and Stevenson, J. (2006) The effect of medroxyprogesterone acetate on estrogen-dependent risks and benefits-an attempt to interpret the women's health initiative results. Gynecology & Endocrinology, 22, pp. 303-317.
12. Singh, M. (2006) Progesterone-induced neuroprotection. Endocrine, 29, pp. 271-274.
13. Cagnacci, A., Arangino, S., Baldassari, F., Alessandrini, C., Landi, S. and Volpe, A. (2004) A comparison of the central effects of different progestins used in hormone replacement therapy. Maturitas, 48, pp. 456-462.
14. Roof, RL, Duvdevani, R. and Stein, DG (1993) Gender influences outcome of brain injury: Progesterone plays a protective role. Brain Research, 607, pp. 333-336.
15. Djebaili, M., Guo, Q., Pettus, EH, Hoffman, SW and Stein, DG (2005) The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. Journal of Neurotrauma, 22, pp. 106-118.
16. Shear, DA, Galani, R., Hoffman, SW and Stein, DG (2002) Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury. Experimental Neurology, 178, pp. 59-67.
17. Abdi H. Z-scores (2007) Encyclopedia of measurement and statistics., pp. 1057-1058. Sage, Thousand Oaks, CA
18. Koubovec, D., Ronacher, K., Stubsrud, E., Louw, A. and Hapgood, JP (2005) Synthetic progestins used in hrt have different glucocorticoid agonist properties. Molecular Cell Endocrinology, 242, pp. 23-32.
19. Shadoan, MK, Kavanagh, K., Zhang, L., Anthony, MS and Wagner, JD (2007) Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue. Metabolism, 56, pp. 830-837.
20. Bernardi, F., Pluchino, N., Pieri, M., Begliuomini, S., Lenzi, E., Puccetti, S., Casarosa, E., Luisi, M. and Genazzani, AR (2006) Progesterone and medroxyprogesterone acetate effects on central and peripheral allopregnanolone and beta-endorphin levels. Neuroendocrinology, 83, pp. 348-359.
21. Nilsen, J., Morales, A. and Brinton, RD (2006) Medroxyprogesterone acetate exacerbates glutamate excitotoxicity. Gynecology & Endocrinology, 22, pp. 355-361.
22. Garcia-Becerra, R., Cooney, AJ, Borja-Cacho, E., Lemus, AE, Perez-Palacios, G. and Larrea, F. (2004) Comparative evaluation of androgen and progesterone receptor transcription selectivity indices of 19-nortestosterone-derived progestins. Journal of Steroid Biochemistry & Molecular Biology, 91, pp. 21-27.
23. Bamberger, CM, Else, T., Bamberger, AM, Beil, FU and Schulte, HM (1999) Dissociative glucocorticoid activity of medroxyprogesterone acetate in normal human lymphocytes. Journal of Clinical Endocrinology Metabolism, 84, pp. 4055-4061.
24. Cutler, SM, Cekic, M., Miller, D., Wali, B., Vanlandingham, JW and Stein, DG (2007) Progesterone improves acute recovery after traumatic brain injury in the aged rat. Journal of Neurotrauma, 24:9, pp. 1475-1486.
25. Vanlandingham, JW, Cekic, M., Cutler, SM, Hoffman, SW and Stein, DG (2007) Neurosteroids reduce inflammation after tbi through cd55 induction. Neuroscience Letters
26. Stein, DG, Wright, DW and Kellermann, AL (2007) Does progesterone have neuroprotective properties?. Annals of Emergency Medicine
27. Schumacher, M., Guennoun, R., Robert, F., Carelli, C., Gago, N., Ghoumari, A., Deniselle, MC Gonzalez, Gonzalez, SL, Ibanez, C. and Labombarda, F. (2004) Local synthesis and dual actions of progesterone in the nervous system: Neuroprotection and myelination. Growth Hormone IGF Research, 14, pp. S18-S33.
28. Schumacher, M., Weill-Engerer, S., Liere, P., Robert, F., Franklin, RJ, Garcia-Segura, LM, Lambert, JJ, Mayo, W., Melcangi, RC and Parducz, A. (2003) Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Progress in Neurobiology, 71, pp. 3-29.
29. Meffre, D., Delespierre, B., Gouezou, M., Schumacher, M., Stein, DG and Guennoun, R. (2007) 3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mrna expression in rat brain: Effect of pseudopregnancy and traumatic brain injury. Journal of Steroid Biochemistry & Molecular Biology, 104, pp. 293-300.
30. Meffre, D., Pianos, A., Liere, P., Eychenne, B., Cambourg, A., Schumacher, M., Stein, DG and Guennoun, R. (2007) Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: Analysis by gas chromatography/mass spectrometry. Endocrinology, 148, pp. 2505-2517.
31. Guennoun, R., Meffre, D., Labombarda, F., Gonzalez, SL, Deniselle, MC, Stein, DG, De Nicola, AF and Schumacher, M. (2007) The membrane-associated progesterone-binding protein 25-dx: Expression, cellular localization and up-regulation after brain and spinal cord injuries. Brain Research Review
32. Meffre, D., Delespierre, B., Gouezou, M. and Leclerc, P. (2005) The membrane-associated progesterone-binding protein 25-dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury. Journal of Neurochemistry, 93, pp. 1314-1326.