Correction of disturbed pathophysiology of hepatic failure by albumin dialysis

Hepatobiliary and Pancreatic Diseases International

Volumn 7, Issue 1, 2008, Pages 19-24

  Williams, Roger ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; AMMONIA; AROMATIC AMINO ACID; BILE ACID; BILIRUBIN; CREATININE; MALONALDEHYDE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TOXIN;

ALBUMIN DIALYSIS; CLINICAL TRIAL; DETOXIFICATION; DISEASE SEVERITY; ELECTRON SPIN RESONANCE; HEPATIC ENCEPHALOPATHY; HUMAN; KIDNEY BLOOD FLOW; LIVER CIRRHOSIS; LIVER FAILURE; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PORTAL HYPERTENSION; REVIEW; VASODILATATION;

HUMANS; LIVER FAILURE, ACUTE; RENAL DIALYSIS; SERUM ALBUMIN; SORPTION DETOXIFICATION;

EID: 39049089950     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Rozga J. Liver support technology - an update. Xenotransplantation 2006;13:380-389.
2. Heemann U, Treichel U, Loock J, Philipp T, Gerken G, Malago M, et al. Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective, controlled study. Hepatology 2002;36:949-958.
3. Stange J, Ramlow W, Mitzner S, Schmidt R, Klinkmann H. Dialysis against a recycled albumin solution enables the removal of albumin-bound toxins. Artif Organs 1993;17:809-813.
4. Stange J, Mitzner S. A carrier-mediated transport of toxins in a hybrid membrane. Safety barrier between a patients blood and a bioartificial liver. Int J Artif Organs 1996;19:677-691.
5. Jalan R, Sen S, Steiner C, Kapoor D, Alisa A, Williams R. Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis. J Hepatol 2003;38:24-31.
6. Mitzner SR, Stange J, Klammt S, Risler T, Erley CM, Bader BD, et al. Improvement of hepatorenal syndrome with extracorporeal albumin dialysis MARS: results of a prospective, randomized, controlled clinical trial. Liver Transpl 2000;6:277-286.
7. Sen S, Davies NA, Mookerjee RP, Cheshire LM, Hodges SJ, Williams R, et al. Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study. Liver Transpl 2004;10:1109-1119.
8. Sorkine P, Ben Abraham R, Szold O, Biderman P, Kidron A, Merchav H, et al. Role of the molecular adsorbent recycling system (MARS) in the treatment of patients with acute exacerbation of chronic liver failure. Crit Care Med 2001;29:1332-1336.
9. Schmidt LE, Svendsen LB, Sorensen VR, Hansen BA, Larsen FS. Cerebral blood flow velocity increases during a single treatment with the molecular adsorbents recirculating system in patients with acute on chronic liver failure. Liver Transpl 2001;7:709-712.
10. Schmidt LE, Wang LP, Hansen BA, Larsen FS. Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial. Liver Transpl 2003;9:290-297.
11. Sen S, Mookerjee RP, Cheshire LM, Davies NA, Williams R, Jalan R. Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitis. J Hepatol 2005; 43:142-148.
12. Sen S, Ratnaraj N, Davies NA, Mookerjee RP, Cooper CE, Patsalos PN, et al. Treatment of phenytoin toxicity by the molecular adsorbents recirculating system (MARS). Epilepsia 2003;44:265-267.
13. Hassanein T, Tofteng F, Brown Jr RS, McGuire BM, Lynch P. Mehta R, et al. Efficacy of albumin dialysis (MARS) in patients with cirrhosis and advanced grades of hepatic encephalopathy: a prospective, controlled, randomized multicenter trial. Hepatology 2004;40:726A.
14. Evenepoel P, Maes B, Wilmer A, Nevens F, Fevery J, Kuypers D, et al. Detoxifying capacity and kinetics of the molecular adsorbent recycling system. Contribution of the different inbuilt filters. Blood Purif 2003;21:244-252.
15. Evenepoel P, Bammens B, Nevens F, Wilmer A, Vanrenterghem Y. The molecular adsorbent recycling system (MARS) and transmembrane transport of albumin-bound toxins. Liver Transpl 2005;11:853-854.
16. Davies NA, Schnurr K, Sen S, Hodges SJ, Matthes G, Jalan R. Serum albumin shows conformational, structural and functional abnormalities in cirrhotic patients, which worsen with severity of liver disease and are unaffected by albumin dialysis. Hepatology 2005;42:222A.
17. Klammt S, Mitzner S, Stange J, Brinkmann B, Drewelow B, Emmrich J, et al. Albumin-binding function is reduced in patients with decompensated cirrhosis and correlates inversely with severity of liver disease assessed by model for end-stage liver disease. Eur J Gastroenterol Hepatol 2007;19:257-263.
18. Lee KH, Wendon J, Lee M, Da Costa M, Lim SG, Tan KC. Predicting the decrease of conjugated bilirubin with extracorporeal albumin dialysis MARS using the predialysis molar ratio of conjugated bilirubin to albumin. Liver Transpl 2002;8:591-593.
19. Steiner C, Sen S, Stange J, Williams R, Jalan R. Binding of bilirubin and bromosulphthalein to albumin: implications for understanding the pathophysiology of liver failure and its management. Liver Transpl 2004;10:1531-1538.
20. Sauer IM, Goetz M, Steffen I, Walter G, Kehr DC, Schwartlander R, et al. In vitro comparison of the molecular adsorbent recirculation system (MARS) and single-pass albumin dialysis (SPAD). Hepatology 2004;39:1408-1414.
21. Peszynski P, Klammt S, Peters E, Mitzner S, Stange J, Schmidt R. Albumin dialysis: single pass vs. recirculation (MARS). Liver 2002;22 Suppl 2:40-42.
22. Krisper P. Haditsch B, Stauber R, Jung A, Stadlbauer V, Trauner M, et al. In vivo quantification of liver dialysis: comparison of albumin dialysis and fractionated plasma separation. J Hepatol 2005;43:451-457.
23. Santoro A, Faenza S, Mancini E, Ferramosca E, Grammatico F, Zucchelli A, et al. Prometheus system: a technological support in liver failure. Transplant Proc 2006;38:1078-1082.
24. Laleman W, Wilmer A, Evenepoel P, Elst IV, Zeegers M, Zaman Z, et al. Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure. Crit Care 2006;10: R108.