Synthesis and evaluation of [123I] labeled iodovinyl amino acids syn-, anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid, and 1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid as potential SPECT brain tumor imaging agents

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 4, 2008, Pages 1264-1268

  Yu, Weiping ^a   Williams, Larry ^a   Malveaux, Eugene ^a   Camp, Vernon M ^a   Olson, Jeffrey J ^a   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

9L gliosarcoma; Amino acids; Brain tumor; Iodine 123; LAT; Rats; SPECT

Indexed keywords

1 AMINO 3 [2 IODOETHENYL]CYCLOBUTANE 1 CARBOXYLIC ACID I 123; 1 AMINO 3 IODOMETHYLENE CYCLOBUTANE 1 CARBOXYLIC ACID I 123; CALCIUM CHANNEL L TYPE; IODOVINYL AMINO ACID I 123; TRACER; UNCLASSIFIED DRUG; 1 AMINO 3 (2 IODOETHENYL)CYCLOBUTANE 1 CARBOXYLIC ACID; 1 AMINO 3 IODOMETHYLENE CYCLOBUTANE 1 CARBOXYLIC ACID; 1-AMINO-3-(2-IODOETHENYL)CYCLOBUTANE-1-CARBOXYLIC ACID; 1-AMINO-3-IODOMETHYLENE-CYCLOBUTANE-1-CARBOXYLIC ACID; CARBOXYLIC ACID; CYCLOBUTANE DERIVATIVE; DIAGNOSTIC AGENT; RADIOACTIVE IODINE; RADIOPHARMACEUTICAL AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TUMOR; CANCER CELL CULTURE; DRUG SYNTHESIS; GLIOSARCOMA; IN VITRO STUDY; NONHUMAN; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; BRAIN; CHEMISTRY; FISCHER 344 RAT; METABOLISM; METHODOLOGY; SCINTISCANNING; STEREOISOMERISM; SYNTHESIS; TISSUE DISTRIBUTION;

RATTUS;

ANIMALS; BRAIN; BRAIN NEOPLASMS; CARBOXYLIC ACIDS; CYCLOBUTANES; GLIOSARCOMA; IODINE RADIOISOTOPES; RADIOPHARMACEUTICALS; RATS; RATS, INBRED F344; STEREOISOMERISM; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 38949212993     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.035     Document Type: Article

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