Isolation and characterization of process related impurities of olanzapine using HPLC and ESI-MS/MS

Journal of Separation Science

Volumn 31, Issue 1, 2008, Pages 107-118

  Rao, Ramisetti Nageswara ^a   Raju, Ale Narasa ^a   Narsimha, Ramaram ^a   Babu, Ganduri Raveendra ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b ANNAMALAI UNIVERSITY   (India)

Author keywords

Atypical antipsychotic; Isolation and characterization; Olanzapine; Process impurities; Schizophrenia

Indexed keywords

CONCENTRATION (PROCESS); DRUG PRODUCTS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; SEPARATION; SOLVENTS;

ATYPICAL ANTIPSYCHOTIC; OLANZAPINE; PROCESS IMPURITIES; SCHIZOPHRENIA;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

AMMONIUM ACETATE; ATYPICAL ANTIPSYCHOTIC AGENT; BUFFER; OLANZAPINE; SOLVENT;

ACCURACY; ARTICLE; DRUG DETERMINATION; DRUG FORMULATION; DRUG IMPURITY; DRUG ISOLATION; DRUG MANUFACTURE; DRUG PURITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; FLOW RATE; INFRARED SPECTROSCOPY; MASS SPECTROMETER; PARTICLE SIZE; PH; PHASE SEPARATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; SPECTROPHOTOMETER; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

BENZODIAZEPINES; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 38949205184     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200700397     Document Type: Article

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