Olanzapine concentrations in clinical serum and postmortem blood specimens - When does therapeutic become toxic?

Journal of Forensic Sciences

Volumn 45, Issue 2, 2000, Pages 418-421

  Robertson, Michael D ^a   McMullin, Matthew M ^a  

^a National Medical Services Inc   (United States)

Author keywords

Antipsychotic; Clinical toxicology; Forensic science; Forensic toxicology; Olanzapine; Postmortem; Therapeutic; Zyprexa

Indexed keywords

OLANZAPINE;

ARTICLE; AUTOPSY; CAUSE OF DEATH; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG INTOXICATION; GAS CHROMATOGRAPHY; HUMAN; PLASMA; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

ANTIPSYCHOTIC AGENTS; AUTOPSY; BENZODIAZEPINES; BLOOD CHEMICAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FORENSIC MEDICINE; HUMANS; PIRENZEPINE;

EID: 0034061823     PISSN: 00221198     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Fulton B, Goa KL. Olanzapine. A review of its pharmacological properties and therapeutic efficacy in the management of schizophrenic and related psychoses. Drugs 1997;Feb;53(2):281-98.
2. Bymaster FP, Zalligaro DO, Falcone JF, et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacol 1996;14:87-96.
3. Casey DE. The relationship of pharmacology to side effects. J Clin Psychiat 1997;58(Suppl 10):55-62.
4. Levine BS, Wu SC, Smialek JE. Olanzapine concentrations in forensic investigations. In: Monforte JR, editor. ToxTalk; 22(4) Abstracts of the Joint Meeting of the Society of Forensic Toxicologists and the International Association of Forensic Toxicologists, 5-9 Oct. 1998; Albuquerque, NM. 1998;48.
5. Perry PJ, Sanger T, Beasley C. Olanzapine serum concentrations and clinical response in acutely in schizophrenic patients. J Clin Psychopharmacol 1997;Dec;17(6):472-7.
6. Ereshefsky L. Pharmacokinetics and drug interactions: update for new antipsychotics. J Clin Psychiat 1996;57(Suppl 11):12-5.
7. Elian AA. Fatal overdose of olanzapine. Forensic Sci Int 1998;Feb;91 (3):231-5.
8. Anderson DT, Kuwahara T. Thirty case studies involving postmortem tissue distribution of olanzapine (Zyprexa). In: Monforte JR, editor. ToxTalk; 22(4) Abstracts of the Joint Meeting of the Society of Forensic Toxicologists and the International Association of Forensic Toxicologists, 5-9 Oct. 1998; Albuquerque, NM. 1998;47-8.
9. Stephens BG, Coleman DE, Baselt RC. Olanzapine-related fatality. J Forensic Sci 1998;43(6):1252-3.
10. Xue L, Crookham SB, Diamond FX, Davis PJ, Rieber TM. Development of a gas chromatographic method for the determination of olanzapine in human serum, and a report of patient values. Clin Chem 1998;44(6): A103.
11. Wong SKY, Gock SB, Venuti SE, Stormo A, Greenbaum VJ, Biedrzycki LM, et al. Olanzapine associated deaths: a report of five cases. In: Monforte JR, editor. ToxTalk; 22(4) Abstracts of the Joint Meeting of the Society of Forensic Toxicologists and the International Association of Forensic Toxicologists, 5-9 Oct. 1998; Albuquerque, NM. 1998;48-9.
12. Stevens HM. The stability of some drugs and poisons in putrefying human liver tissues. J Forensic Sci Soc 1984;24:577-89.