Overexpression of cellular iron import proteins is associated with malignant progression of esophageal adenocarcinoma

Clinical Cancer Research

Volumn 14, Issue 2, 2008, Pages 379-387

  Boult, Jessica ^a   Roberts, Keith ^a   Brookes, Matthew J ^a   Hughes, Sharon ^a   Bury, Jonathan P ^c   Cross, Simon S ^c   Anderson, Gregory J ^d   Spychal, Robert ^b   Iqbal, Tariq ^a   Tselepis, Chris ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b SANDWELL AND WEST BIRMINGHAM HOSPITALS NHS TRUST   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CARRIER PROTEIN; CD71 ANTIGEN; CELLULAR IRON IMPORT PROTEIN; CYTOCHROME B; FERRITIN; FERROPORTIN; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; BARRETT ESOPHAGUS; BREAST CARCINOGENESIS; CANCER GROWTH; CELL LINE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ESOPHAGEAL ADENOCARCINOMA; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IRON STORAGE; IRON TRANSPORT; PRECANCER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ADENOCARCINOMA; ANTIGENS, CD; APOFERRITINS; BARRETT ESOPHAGUS; CATION TRANSPORT PROTEINS; CYTOCHROME B GROUP; DISEASE PROGRESSION; ESOPHAGEAL NEOPLASMS; HUMANS; IRON; OXIDOREDUCTASES; RECEPTORS, TRANSFERRIN;

EID: 38949193907     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-1054     Document Type: Article

References (40)

1. Lagergren J. Adenocarcinoma of oesophagus: what exactly is the size of the problem and who is at risk? [review]. Gut 2005;54 Suppl 1:i1-5.
2. Bollschweiler E, Wolfgarten E, Gutschow C, Holscher AH. Demographic variations in the rising incidence of esophageal adenocarcinoma in white males. Cancer 2001;92:549-55.
3. Survival of cancer patients in Europe: The EUROCARE II study. Lyon: IARC; 1999.
4. Jankowski JA, Harrison RF, Perry I, Balkwill F, Tselepis C. Barrett's metaplasia. Lancet 2000;356:2079-85.
5. Solaymani-Dodaran M, Logan RF, West J, Card T, Coupland C. Risk of oesophageal cancer in Barrett's oesophagus and gastro-oesophageal reflux. Gut 2004;53:1070-4.
6. Hage M, Siersema PD, van Dekken H, Steyerberg EW, Dees J, Kuipers EJ. Oesophageal cancer incidence and mortality in patients with long-segment Barrett's oesophagus after a mean follow-up of 12.7 years. Scand J Gastroenterol 2004;39:1175-9.
7. Tselepis C, Morris CD, Wakelin D, et al. Upregulation of the oncogene c-myc in Barrett's adenocarcinoma: induction of c-myc by acidified bile acid in vitro. Gut 2003;52:174-80.
8. Koppert LB, Wijnhoven BP, van Dekken H, Tilanus HW, Dinjens WN. The molecular biology of esophageal adenocarcinoma [review]. J Surg Oncol 2005;92:169-90.
9. Chen X, Yang CS. Esophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis and chemoprevention [review]. Carcinogenesis 2001;22:1119-29.
10. Chen X, Ding YW, Yang G, Bondoc F, Lee MJ, Yang CS. Oxidative damage in an esophageal adenocarcinoma model with rats. Carcinogenesis 2000;21:257-63.
11. Chen X, Yang G, Ding WY, Bondoc F, Curtis SK, Yang CS. An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload. Carcinogenesis 1999;20:1801-8.
12. Goldstein SR, Yang GY, Chen X, Curtis SK, Yang CS. Studies of iron deposits, inducible nitric oxide synthase and nitrotyrosine in a rat model for esophageal adenocarcinoma. Carcinogenesis 1998;19:1445-9.
13. Hsing AW, McLaughlin JK, Olsen JH, Mellemkjar L, Wacholder S, Fraumeni JF, Jr. Cancer risk following primary hemochromatosis: a population-based cohort study in Denmark. Int J Cancer 1995;60:160-2.
14. Lee DH, Anderson KE, Folsom AR, Jacobs DR, Jr. Heme iron, zinc and upper digestive tract cancer: the Iowa Women's Health Study. Int J Cancer 2005;117:643-7.
15. Brookes MJ, Hughes S, Turner FE, et al. Modulation of iron transport proteins in human colorectal carcinogenesis. Gut 2006;55:1449-60.
16. Huang X. Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal [review]. Mutat Res 2003;533:153-71.
17. Le NT, Richardson DR. The role of iron in cell cycle progression and the proliferation of neoplastic cells [review]. Biochim Biophys Acta 2002;1603:31-46.
18. Bilello JP, Cable EE, Isom HC. Expression of E-cadherin and other paracellular junction genes is decreased in iron-loaded hepatocytes. Am J Pathol 2003;162:1323-38.
19. McKie AT, Barrow D, Latunde-Dada GO, et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 2001;291:1755-9.
20. Gruenheid S, Cellier M., Vidal S, Gros P. Identification and characterization of a second mouse Nramp gene. Genomics 1995;25:514-25.
21. Gunshin H, Mackenzie B, Berger U, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997;388:482-8.
22. Torti SV, Kwak EL, Miller SC, et al. The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. J Biol Chem1988;263:12638-44.
23. Frazer DM, Vulpe CD, McKie AT, et al. Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins. Am J Physiol Gastrointest Liver Physiol 2001;281:G931-9.
24. Vulpe CD, Kuo YM, Murphy TL, et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 1999;21:195-9.
25. McKie AT, Marciani P, Rolfs A, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 2000;5:299-309.
26. Aisen P. Transferrin receptor 1. Int J Biochem Cell Biol 2004;36:2137-43.
27. Brookes MJ, Boult J, Roberts K, et al. A role for iron in Wnt signalling. Oncogene. Epub ahead of print 2007 Aug 13.
28. Martino E, Wild CP, Rotimi O, Darnton JS. Olliver RJ, Hardie LJ. IGFBP-3 and IGFBP-10 (CYR61) up-regulation during the development of Barrett's oesophagus and associated oesophageal adenocarcinoma: potential biomarkers of disease risk. Biomarkers 2006;11:547-61.
29. Rockett JC, Larkin K, Darnton SJ, Morris AG, Matthews HR. Five newly established oesophageal carcinoma cell lines: phenotypic and immunological characterization. Br J Cancer 1997;75:258-63.
30. Hughes SJ, Nambu Y, Soldes OS, et al. Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma. Cancer Res 1997;57:5571-8.
31. O'Donnell KA, Yu D, Zeller KI, et al. Activation of transferrin receptor 1by c-Myc enhances cellular proliferation and tumorigenesis. Mol Cell Biol 2006;26:2373-86.
32. Altman DG. Practical statistics for medical research. New York: Chapman & Hall; 1991.
33. Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update [review]. Ann N Y Acad Sci 2004;1012:1-13.
34. Rouault TA. The role of iron regulatory proteins in mammalian iron homeostasis and disease [review]. Nat Chem Biol 2006;2:406-14.
35. Wu KJ, Polack A, Dalla-Favera R. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science 1999;283:676-9.
36. Wang G, Miskimins R, Miskimins WK. Regulation of p27 (Kip1) by intracellular iron levels. Biometals 2004;17:15-24.
37. Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 2000;275:19906-12.
38. Thelander L, Gräslund A, Thelander M. Continual presence of oxygen and iron are required for mammalian ribonucleotide reduction: possible regulation mechanism. Biochem Biophys Res Commun 1983;110:859-65.
39. Sanchez M, Galy B, Dandekar T, et al. Iron regulation and the cell cycle: identification of an iron-responsive element in the 3′-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J Biol Chem 2006;281:22865-74.
40. Le NT, Richardson DR. Iron chelators with high anti-proliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation. Blood 2004;104:2967-75