New 1,2,3,4-tetrahydroisoquinoline derivatives as modulators of proteolytic cleavage of amyloid precursor proteins

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 1957-1965

  Hu, Ming Kuan ^a   Liao, Yung Feng ^b   Chen, Jung Fang ^a   Wang, Bo Jeng ^b   Tung, Ying Tsen ^b   Lin, Hui Ching ^a   Lee, Kang Po ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

Secretase; Alzheimer's disease; Amyloid precursor protein; Tetrahydroisoquinolines

Indexed keywords

7 (1 MORPHOLINECARBAMOYLOXY) N CYCLOPROPYLMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 (1 MORPHOLINECARBAMOYLOXY) N PROPARGYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 (1 PIPERIDINECARBAMOYLOXY) N CYCLOPROPYLMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 (1 PIPERIDINECARBAMOYLOXY) N PROPARGYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 (1 PYRROLIDINECARBAMOYLOXY) N CYCLOPROPYLMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 (1 PYRROLIDINECARBAMOYLOXY) N PROPARGYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 (N METHYL N ETHYLCARBAMOYLOXY) N CYCLOPROPYLMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 (N METHYL N ETHYLCARBAMOYLOXY) N PROPARGYL 1,2,3,4 TETRAHYDROISOQUINOLINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; QUINOLINE DERIVATIVE; RASAGILINE; UNCLASSIFIED DRUG;

ALKYLATION; ALZHEIMER DISEASE; ARTICLE; BAEYER VILLIGER REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NEUROPROTECTION; PROTEIN DEGRADATION; PROTEIN SECRETION; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; SIMULATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYDROLYSIS; NEUROPROTECTIVE AGENTS; PEPTIDE HYDROLASES; TETRAHYDROISOQUINOLINES;

EID: 38949121975     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.101     Document Type: Article

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