Focus on research: Hutchinson-Gilford progeria syndrome, aging, and the nuclear lamina

New England Journal of Medicine

Volumn 358, Issue 6, 2008, Pages 552-554

  Korf, Bruce ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LAMIN A; MESSENGER RNA; NUCLEOTIDE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; LMNA PROTEIN, HUMAN; UNCLASSIFIED DRUG;

AGING; CELL NUCLEUS MEMBRANE; CLINICAL FEATURE; DNA REPAIR; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; LMNA GENE; NUCLEAR LAMINA; PATHOPHYSIOLOGY; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; PROGERIA; RNA SPLICING; SHORT SURVEY; UNSPECIFIED SIDE EFFECT; WERNER SYNDROME; BIOSYNTHESIS; GENETICS; METABOLISM; NOTE; PHYSIOLOGY; POINT MUTATION; PROTEIN SYNTHESIS;

AGING; HUMANS; LAMIN TYPE A; NUCLEAR LAMINA; PHENOTYPE; POINT MUTATION; PROGERIA; PROTEIN BIOSYNTHESIS; RNA SPLICING;

EID: 38949083229     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp0800071     Document Type: Article

References (5)

1. Capell BC, Collins FS. Human laminopathies: nuclei gone genetically awry. Nat Rev Genet 2006;7:940-52.
2. Liu B, Wang J, Chan KM, et al. Genomic instability in laminopathy-based premature aging. Nat Med 2005;11:780-5.
3. Chen L, Lee L, Kudlow BA, et al. LMNA mutations in atypical Werner's syndrome. Lancet 2003;362:440-5.
4. Yang SH, Meta M, Qiao X, et al. A farnesyl-transferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest 2006;116:2115-21.
5. Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science 2006;312:1059-63.