Effects of caudal hindbrain lactate infusion on insulin-induced hypoglycemia and neuronal substrate transporter glucokinase and sulfonylurea receptor-1 gene expression in the ovariectomized female rat dorsal vagal complex: Impact of estradiol

Journal of Neuroscience Research

Volumn 86, Issue 3, 2008, Pages 694-701

  Vavaiya, Kamlesh V ^a   Briski, Karen P ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Dorsal vagal complex; Glucokinase; GLUT3; GLUT4; Insulin; Lactate; MCT2; SUR

Indexed keywords

ESTRADIOL; GLUCOKINASE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; INSULIN; LACTIC ACID; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 2; POTASSIUM CHANNEL; SODIUM CHLORIDE; SULFONYLUREA RECEPTOR 1;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENERGY TRANSFER; ENZYME SUBSTRATE; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RHOMBENCEPHALON; UPREGULATION; VAGUS NERVE DORSAL NUCLEUS;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DRUG IMPLANTS; ESTRADIOL; ESTROGENS; FEMALE; FOURTH VENTRICLE; GENE EXPRESSION; GLUCOKINASE; HYPOGLYCEMIA; INJECTIONS; INJECTIONS, INTRAVENTRICULAR; INSULIN; LACTIC ACID; MONOCARBOXYLIC ACID TRANSPORTERS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEURONS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RHOMBENCEPHALON; RNA, MESSENGER;

EID: 38849208638     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21530     Document Type: Article

References (38)

1. Adachi A, Kobashi M, Funahashi M. 1995. Glucose-responsive neurons in the brainstem. Obesity Res 3:735S-740S.
2. Adams JM, Legan SJ, Ott CE, Jackson BA. 2005. Modulation of hypoglycemia-induced increases in plasma epinephrine by estrogen in the female rat. J Neurosci Res 79:360-367.
3. + channels. Pflugers Arch 415:479-483.
4. Balfour RH, Hansen AMK, Trapp S. 2006. Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem. J Physiol 570:469-484.
5. Bliss TA, Sapolsky RM. 2001. Interactions among glucose, lactate, and adenosine regulate energy substrate utilization in hippocampal cultures. Brain Res 899:134-141.
6. Bouzier-Sore AK, Voisin P, Canioni P, Magistretti PJ, Pellerin L. 2003. Lactate is a preferential oxidative substrate over glucose for neurons in culture. J Cereb Blood Flow Metab 23:1298-1306.
7. Briski KP, Marshall ES, Sylvester PW. 2001. Effects of estradiol on glucoprivic transactivation of catecholaminergic neurons in the female rat caudal brainstem. Neuroendocrinology 73:369-377.
8. Broer S, Rahman B, Pellegri G, Pellerin L, Martin JL, Verleysdonk S, Hamprecht B, Magistretti PJ. 1997. Comparison of lactate transport in astroglial cells and monocarboxylate transporter (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J Biol Chem 272:30096-30102.
9. Cagampang FRA, Cates PS, Sandhu S, Strutton PH, McGarvey C, Coen CW, O'Byrne KT. 1997. Hypoglycemia-induced inhibition of pulsatile luteinizing hormone secretion in female rats: role of oestradiol, endogenous opioids and the adrenal medulla. J Neuroendocrinol 9:867-872.
10. + channels in glucose-sensing in the rat solitary tract nucleus. Neurosci Lett 278:77-80.
11. Devaskar SU, Mueckler M. 1991. The mammalian glucose transporters. Pediatr Res 31:1-13.
12. Goubillon ML, Thalabard JC. 1996. Insulin-induced hypoglycemia decreases luteinizing hormone secretion in the castrated male rat: involvement of opiate peptides. Neuroendocrinology 64:49-56.
13. Haywood SA, Simonian SX, van der Beek EM, Bicknell RJ, Herbison AE. 1999. Fluctuating estrogen and progesterone receptor expression in brainstem norepinephrine neurons through the rat estrous cycle. Endocrinology 140:3255-3263.
14. Himmi T, Perrin J, Dallaporta M, Orsini JC. 2001. Effects of lactate on glucose-sensing neurons in the solitary tract nucleus. Physiol Behav 74:391-397.
15. Izumi Y, Benz AM, Katsuki H, Zorumski CF. 1997. Endogenous monocarboxylates sustain hippocampal synaptic function and morphological integrity during energy deprivation. J Neurosci 17:9448-9457.
16. Kale AY, Vavaiya KV, Briski KP. 2006. Effects of acute and chronic insulin-induced hypoglycemia on type II glucocorticoid receptor (GR) gene expression in characterized CNS metabolic loci in male rat brain. Brain Res Bull 70:240-244.
17. Komesaroff PA, Esler M, Clarke IJ, Fullerton MJ, Funder JW. 1998. Effects of estrogen and estrous cycle on glucocorticoid and catecholamine responses to stress in sheep. Am J Physiol 275:E671-E678.
18. Laming PR, Kimelberg H, Robinson S, Salm A, Hawrylak N, Muller C, Roots B, Ng K. 2000. Neuronal-glial interactions and behavior. Neurosci Biobehav Rev 24:295-340.
19. Magistretti PJ, Pellerin L. 1999. Astrocytes couple synaptic activity to glucose utilization in the brain. News Physiol Sci 14:177-182.
20. McDermott JJ, Jorgensen DE, Byers DJ. 1984. Estradiol and progesterone suppress feeding induced by 2-deoxy-D-glucose. Physiol Behav 32:731-736.
21. + channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 4:507-512.
22. Mizuno Y, Oomura Y. 1984. Glucose responding neurons in the nucleus tractus solitarius of the rat: in vitro study. Brain Res 307:109-116.
23. Nagatani S, Tsukamaura H, Maeda K. 1994. Estrogen feedback needed at the paraventricular nucleus or A2 to suppress pulsatile luteinizing hormone release in fasting female rats. Endocrinology 135:870-875.
24. Oomura Y, Ono T, Ooyama H, Wayner MJ. 1969. Glucose and osmosensitive neurones of the rat hypothalamus. Nature 222:282-284.
25. Paranjape SA, Kale AY, Briski KP. 2006. Habituation of insulin-induced hypoglycemic transcription activation of lateral hypothalamic orexin-A-containing neurons to recurring exposure. Regul Pept 135:1-6.
26. Patil GD, Briski KP. 2005. Lactate is a critical "sensed" variable in caudal hindbrain monitoring of CNS metabolic stasis. Am J Physiol 289:R1777-R1786.
27. Sandoval DA, Ertl AC, Richardson MA, Tate DB, Davis SN. 2003. Estrogen blunts neuroendocrine and metabolic responses to hypoglycemia. Diabetes 52:1749-1755.
28. Schurr A, Payne RS, Miller JJ, Rigor BM. 1997a. Brain lactate is an obligatory aerobic energy substrate for functional recovery after hypoxia: further in vitro validation. J Neurochem 69:423-426.
29. Schurr A, Payne RS, Miller JJ, Rigor BM. 1997b. Brain lactate, not glucose, fuels the recovery of synaptic function from hypoxia upon reoxygenation: an in vitro study. Brain Res 744:105-111.
30. Silver IA, Erecinska M. 1998. Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons. J Neurophysiol 79:1733-1745.
31. Simerly RB, Chang C, Muramatsu M, Swanson LW. 1990. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol 294:76-95.
32. Simonian SX, Herbison AE. 1997. Differential expression of estrogen receptor and neuropeptide Y by brainstem A1 and A2 noradrenaline neurons. Neuroscience 76:517-529.
33. Swanson L. 1999. Brain maps: Structure of the rat brain. 2nd ed. New York, Elsevier.
34. Thurston JH, Haubart RE, Schiro JA. 1983. Lactate reverses insulin-induced hypoglycemic stupor in suckling-weanling mice: biochemical correlates in blood, liver, and brain. J Cereb Blood Flow Metab 3:498-506.
35. Vannucci SJ, Maher F, Simpson IA. 1997. Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 21:2-21.
36. Vavaiya KV, Paranjape SA, Briski KP. 2006. Vagal complex monocarboxylate transporter-2 expression during hypoglycemia. Neuroreport 17:1023-1026.
37. Vavaiya K, Paranjape SA, Briski KP. 2007. Testicular regulation of neuronal glucose and monocarboxylate transporter gene expression profiles in CNS metabolic sensing sites during acute and recurrent insulin-induced hypoglycemia. J Mol Neurosci 31:37-46.
38. Wade GN, Schneider JE. 1992. Metabolic fuels and reproduction in female mammals. Neurosci Biobehav Rev 16:235-272.