Testicular regulation of neuronal glucose and monocarboxylate transporter gene expression profiles in CNS metabolic sensing sites during acute and recurrent insulin-induced hypoglycemia

Journal of Molecular Neuroscience

Volumn 31, Issue 1, 2007, Pages 37-46

  Vavaiya, Kamlesh V ^a   Paranjape, Sachin A ^a   Briski, Karen P ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Dorsal vagal complex; GLUT3; GLUT4; Lateral hypothalamic area; MCT2; Recurrent insulin induced hypoglycemia; Ventromedial nucleus hypothalamus

Indexed keywords

CARBOXYLIC ACID; GLUCOSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 4; INSULIN; LACTIC ACID; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MONITORING; BRAIN METABOLISM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; HYPOGLYCEMIA; LATERAL HYPOTHALAMUS; MALE; NONHUMAN; ORCHIECTOMY; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECURRENT DISEASE; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS; VAGUS NERVE DORSAL NUCLEUS;

ANIMALS; BRAIN; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 3; GLUCOSE TRANSPORTER TYPE 4; HOMEOSTASIS; HUMANS; HYPOGLYCEMIA; INSULIN; MALE; MONOCARBOXYLIC ACID TRANSPORTERS; NEURONS; ORCHIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; TESTIS;

RATTUS; RODENTIA;

EID: 34247157356     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02686116     Document Type: Article

References (33)

1. Adachi A., Kobashi M., and Funahashi M. (1995) Glucose-responsive neurons in the brainstem. Obesity Res. 3, 735S-740S.
2. Ames A. (2000) CNS energy metabolism as related to function. Brain Res. Rev. 34, 42-68.
3. Borg M. A., Sherwin R. S., Borg W. P., Tamborlane W. V., and Shulman G. I. (1997) Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J. Clin. Invest. 99, 361-365.
4. Borg W. P., Sherwin R. S., During M. J., Borg M. A., and Shulman G. I. (1995) Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 44, 180-184.
5. Broer S., Rahman B., Pellegri G., Pellerin L., Martin J. L., Verleysdonk S., et al. (1997) Comparison of lactate transport in astroglial cells and monocarboxylate transporter (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J. Biol. Chem. 272, 30,096-30,102.
6. Clancy A. N., Bonsall R. W., and Michael R. P. (1992) Immunohistochemical labeling of androgen receptors in the brain of rat and monkey. Life Sci. 50, 409-417.
7. Cryer P. E. and Polonsky K. S. (1997) Glucose homeostasis and hypoglycemia, in Williams Textbook of Endocrinology, 9th ed., Wilson, J. D., and Foster, D. W., eds., W. B. Saunders, Philadelphia, PA, pp. 939-971.
8. Davis M. and Shamoon H. (1991) Counterregulatory adaptation to recurrent hypoglycemia in normal humans. J. Clin. Endocrinol. Metab. 73, 995-1001.
9. Devaskar S. U. and Mueckler M. (1991) The mammalian glucose transporters. Ped. Res. 31, 1-13.
10. Duelli R., Staudt R., Duembgen L., and Kuschinksy W. (1999) Increase in glucose transporter densities of Glut3 and decrease of glucose utilization in rat brain after one week of hypoglycemia. Brain Res. 831, 254-262.
11. Erecinska M. and Silver I. A. (1994) Ions and energy in mammalian brain. Prog. Neurobiol. 43, 37-71.
12. Genabai T. and Briski K. P. (2006) Effects of testosterone on recurrent insulin-induced hypoglycemia (RIIH) in the orchidectomized male rat. Am. Diabetes Assoc., Abstract 623-P.
13. Gerhart D. Z., Leino R. L., Borson N. D., Taylor W. E., Gronlund K. M., McCall A. L., and Drewes L. R. (1995) Localization of glucose transporter GLUT 3 in brain: comparison of rodent and dog using species-specific carboxy-terminal antisera. Neuroscience 66, 237-246.
14. Himmi T., Perrin J., Dallaporta M., and Orsini J. C. (2001) Effects of lactate on glucose-sensing neurons in the solitary tract nucleus. Physiol. Behav. 74, 391-397.
15. Lee D. H., Chung M. Y., Lee J. U., Kang D. G., and Paek Y. W. (2000) Changes of glucose transporters in the cerebral adaptation to hypoglycemia. Diabet. Res. Clin. Prac. 47, 15-23.
16. Leloup C., Arluison M., Kassis N., Lepetit N., Cartier N., Ferre P., and Penicaud L. (1996) Discrete brain areas express the insulin-responsive glucose transporter GLUT4. Mol. Brain Res. 38, 45-53.
17. Mizuno Y. and Oomura Y. (1984) Glucose responding neurons in the nucleus tractus solitarius of the rat: in vitro study. Brain Res. 307, 109-116.
18. Oomura Y., Ono T., Ooyama H., and Wayner M. J. (1969) Glucose and osmosensitive neurones of the rat hypothalamus. Nature 222, 282-284.
19. Paranjape S. A. and Briski K. P. (2005) Recurrent insulin-induced hypoglycemia causes site-specific patterns of habituation or amplification of CNS neuronal genomic activation. Neuroscience 130, 957-970.
20. Pellerin L., Pellegri G., Bittar P. G., Charnay Y., Bouras C., Martin J. L., et al. (1998) Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev. Neurosci. 20, 291-299.
21. Pierre K. and Pellerin L. (2005) Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J. Neurochem. 94, 1-14.
22. Ritter S., Dinh T. T., and Zhang Y. (2000) Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res. 856, 37-47.
23. Roselli C. E., Handa R. J., and Resko J. A. (1989) Quantitative distribution of nuclear androgen receptors in microdissected areas of the rat brain. Neuroendocrinology 49, 449-453.
24. Sar M., Lubahn D. B., French F. S., and Wilson E. M. (1990) Immunohistochemical localization of the androgen receptor in rat and human tissues. Endocrinology 127, 3180-3186.
25. Schurr A., West C. A., and Rigor B. M. (1988) Lactate-supported synaptic function in the rat hippocampal slice preparation. Science 240, 1326-1328.
26. Silver I. A. and Erecinska M. (1998) Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons. J. Neurophysiol. 79, 1733-1745.
27. Simerly R. B., Chang C., Muramatsu M., and Swanson L. W. (1990) Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J. Comp. Neurol. 294, 76-95.
28. Song Z. and Routh V. H. (2005) Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 54, 15-22.
29. Swanson L. W. (1999) Brain Maps: Structure of the Rat, Elsevier, New York.
30. Uehara T., Nipper V., and McCall A. L. (1997) Chronic insulin hypoglycemia induced GLUT-3 protein in rat brain neurons. Am. J. Physiol. 272, E716-E719.
31. Vannucci S. J., Maher F., and Simpson I. A. (1997) Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 21, 2-21.
32. Walz W. and Mukerji S. (1988) Lactate release from cultured astrocytes and neurons: a comparison. Glia 1, 366-370.
33. Yoshimatsu H., Egawa M., and Bray G. A. (1991) Adrenal sympathetic nerve activity in response to hypothalamic injections of 2-deoxy-D-glucose. Am. J. Physiol. 261, R875-R881.