The effects of maximal treadmill graded exercise testing on haemorheological, haemodynamic and flow cytometry platelet markers in patients with systolic or diastolic heart failure

European Journal of Clinical Investigation

Volumn 38, Issue 3, 2008, Pages 150-158

  Chung, I ^a,b   Goyal, D ^a,b   MacFadyen, R J ^a,b   Lip, G Y H ^a,b  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b CITY HOSPITAL   (United Kingdom)

Author keywords

CD40L; Heart failure; P selectin; Platelet activation; SCD40L

Indexed keywords

CD40 LIGAND; CD63 ANTIGEN; OXYGEN; PADGEM PROTEIN;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; BLOOD RHEOLOGY; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC HEART FAILURE; EXERCISE INTENSITY; EXERCISE TOLERANCE; FEMALE; FLOW CYTOMETRY; HEART EJECTION FRACTION; HEMATOCRIT; HEMODYNAMICS; HUMAN; MALE; PRIORITY JOURNAL; SYSTOLIC HEART FAILURE; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTE VOLUME; THROMBOGENESIS; TREADMILL EXERCISE;

AGED; ANTIGENS, CD; BIOLOGICAL MARKERS; BLOOD PLATELETS; EXERCISE; EXERCISE TOLERANCE; FEMALE; FLOW CYTOMETRY; HEART FAILURE, DIASTOLIC; HEART FAILURE, SYSTOLIC; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT;

EID: 38849198641     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2008.01909.x     Document Type: Article

References (24)

1. Lee KW, Lip GYH. Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity: a systematic review. Arch Intern Med 2003 163 : 2368 92.
2. Li N, He S, Blomback M, Hjemdahl P. Platelet activity, coagulation, and fibrinolysis during exercise in healthy males: effects of thrombin inhibition by argatroban and enoxaparin. Arterioscler Thromb Vasc Biol 2007 27 : 407 13.
3. Lekakis J, Triantafyllidi H, Galea V, Koutroumbi M, Theodoridis T, Komporozos C et al. The immediate effect of aerobic exercise on haemostatic parameters in patients with recently diagnosed mild to moderate essential hypertension. J Thromb Thrombolysis 2007 June 6 : [Epub ahead of print].
4. Lee KW, Lip GYH. Acute versus habitual exercise, thrombogenesis and exercise intensity. Thromb Haemostat 2004 91 : 416 9.
5. Manson JE, Hu FB, Rich-Edwards JW, Colditz GA, Stampfer MJ, Willett WC et al. A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. N Engl J Med 1999 341 : 650 8.
6. European Heart Failure Training Group: Exercise from controlled trials of physical training in chronic heart failure. Protocol and patient factor in effectiveness in the improvement of exercise tolerance. Eur Heart J 1998 19 : 466 75.
7. Gibbs C, Blann AD, Edmunds E, Watson RDS, Lip GYH. Effects of acute exercise on haemorheological, endothelial, and platelet markers in patients with chronic heart failure in sinus rhythm. Clin Cardiol 2001 24 : 724 9.
8. Hogg K, Swedberg K, McMurray J. Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis. J Am Coll Cardiol 2004 43 : 317 27.
9. Paulus WJ. Working Group Report. How to diagnose diastolic heart failure. Eur Heart J 1998 19 : 990 1003.
10. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 1974 37 : 247 8.
11. Chapman ES, Sorette M, Hetherington E, Zelmanovic D, Kling G, Dugailliez J et al. A rapid, automated flow cytometric method to measure activated degranulated platelets by density determination. Thromb Haemost 2003 89 : 1004 15.
12. Schmitz G, Rothe G, Ruf A, Barlage S, Tschope D, Clemetson KJ et al. European Working Group on Clinical Cell Analysis: Consensus protocol for the flow cytometric characterization of platelet function. Thromb Haemost 1998 79 : 885 96.
13. Garlichs CD, John A, Schmeber A, Eskafi S, Stumpf C, Karl M et al. Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia. Circulation 2001 104 : 2395 400.
14. Seiss W, Lorenz R, Roth P, Weber PC. Plasma catecholamines, platelet aggregation and associated thromboxane formation after physical exercise, smoking or norepinephrine infusion. Circulation 1982 66 : 44 8.
15. Lindemann S, Klingel B, Fisch A, Meyer J, Darius H. Increased platelet sensitivity toward platelet inhibitors during physical exercise in patients with coronary artery disease. Thromb Res 1999 93 : 51 9.
16. Cipollone F, Mezzetti A, Porreca E, Di Febbo C, Nutini M, Fazia M et al. Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia. Circulation 2002 106 : 399 402.
17. Weber AA, Hermann A, Rauch BH, Schror K. Molecular identity of platelet CD40 Ligand (CD40L). Thromb Haemost 2001 86 : 718.
18. Yilmaz MB, Saricam E, Biyikoglu SF, Guray Y, Guray U, Sasmaz H et al. Mean platelet volume and exercise stress test. J Thromb Thrombolysis 2004 17 : 115 20.
19. Endler G, Klimesch A. Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002 117 : 399 404.
20. Erne P, Wradle J, Sanders K, Lewis SM, Maseri A. Mean platelet volume and size distribution and their sensitivity to agonists in patients with coronary artery disease and congestive heart failure. Thromb Haemostat 1988 59 : 259 63.
21. Smyth DW, Martin JF, Michalis L, Bucknall CA, Jewitt DE. Influence of platelet size before coronary angioplasty on subsequent restenosis. Eur J Clin Invest 1993 23 : 361 7.
22. Macey MG, Carty E, Webb L, Chapman ES, Zelmanovic D, Okrongly D et al. Use of mean platelet component to measure platelet activation on the ADVIA 120 haematology system. Cytometry 1999 38 : 250 5.
23. El-Sayed MS. Effects of exercise on blood coagulation, fibrinolysis and platelet aggregation. Sports Med 1996 22 : 282 98.
24. Ardlie NG, Glew G, Schwartz CJ. Influence of catecholamines on nucleotide-induced platelet aggregation. Nature 1966 212 : 415 7.