Cardiovascular pathophysiology of obesity

High Blood Pressure and Cardiovascular Prevention

Volumn 14, Issue 4, 2007, Pages 207-212

  Antonini, Lanfranco ^a   Grosso, Alessandra ^b   Francalanci, Claudia ^b   Mattei, Rosalba ^b  

^a SAN FILIPPO NERI HOSPITAL   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Cardiovascular remodelling; Cytokines; Endothelial dysfunction; Insulin resistance; Visceral obesity

Indexed keywords

ACETYL STIMULATING PROTEIN; ADIPONECTIN; ANGIOTENSINOGEN; CHOLESTEROL ESTER TRANSFER PROTEIN; ESTROGEN; GLUCOSE; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LEPTIN; LIPID; LIPOPROTEIN LIPASE; NITRIC OXIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN; RETINOL BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADIPOCYTE; ADIPOSE TISSUE; ATHEROGENESIS; ATHEROSCLEROSIS; AUTOCRINE EFFECT; CARDIOVASCULAR DISEASE; DYSLIPIDEMIA; ENDOCRINE GLAND; ENDOTHELIAL DYSFUNCTION; GLUCOSE METABOLISM; HEART LEFT VENTRICLE HYPERTROPHY; HEMODYNAMICS; HUMAN; HYPERINSULINEMIA; HYPERTENSION; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID METABOLISM; NONHUMAN; NOTE; OBESITY; PARACRINE SIGNALING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RENIN ANGIOTENSIN DISORDER; SYMPATHETIC TONE; THROMBOSIS; VASCULAR ENDOTHELIUM;

EID: 38849196974     PISSN: 11209879     EISSN: None     Source Type: Journal    
DOI: 10.2165/00151642-200714040-00002     Document Type: Note

References (38)

1. Kannel WB, McGee D, Gordon T. A general cardiovascular risk profile: the Framingham Study. Am J Cardiol 1976 Jul; 38 (1): 46-51
2. Yusuf S, Hawken S, Ounpuu S, et al. INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364 (9438): 937-52
3. Li L, Yang G, Li Q, et al. High-fat- and lipid-induced insulin resistance in rats: the comparison of glucose metabolism, plasma resistin and adiponectin levels. Ann Nutr Metab 2006 Dec 21; 50 (6): 499-505
4. Barbato A, Cappuccio FP, Folkerd EJ, et al. Metabolic syndrome and renal sodium handling in three ethnic groups living in England. Diabetologia 2004 Jan; 47 (1): 40-6
5. DeFronzo RA. The effect of insulin on renal sodium metabolism: a review with clinical implications. Diabetologia 1981 Sep; 21 (3): 165-71
6. Shi SJ, Vellaichamy E, Chin SY, et al. Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. Am J Physiol Renal Physiol 2003 Oct; 285 (4): F694-702
7. Granger JP, Alexander BT, Llinas M. Mechanisms of pressure natriuresis. Curr Hypertens Rep 2002 Apr; 4 (2): 152-9
8. Ljung T, Holm G, Friberg P, et al. The activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in relation to waist/hip circumference ratio in men. Obes Res 2000 Oct; 8 (7): 487-95
9. O'Hare JA, Minaker KL, Meneilly GS, et al. Effect of insulin on plasma norepinephrine and 3,4-dihydroxyphenylalanine in obese men. Metabolism 1989 Apr; 38 (4): 322-9
10. Karason K, Molgaard H, Wikstrand J, et al. Heart rate variability in obesity and the effect of weight loss. Am J Cardiol 1999 Apr 15; 83 (8): 1242-7
11. Malik M, Camm AJ. Heart rate variability. Armonk (NY): Futura Publishing Company, 1995
12. Hirsch J, Leibel RL, Mackintosh R, et al. Heart rate variability as a measure of autonomic function during weight change in humans. Am J Physiol 1991 Dec; 261 (6 Pt 2): R1418-23
13. Corry DB, Tuck ML. Obesity, hypertension and sympathetic nervous system activity. Curr Hypertens Rep 1995; 1 (2): 119-26
14. Del Colle S, Milan A, Caserta M, et al. Baroreflex sensitivity is impaired in essential hypertension with central obesity. J Hum Hypertens 2007 Jun; 21 (6): 473-8
15. Ogawa Y, Kanbayashi T, Saito Y, et al. Total sleep deprivation elevates blood pressure through arterial baroreflex resetting: a study with microneurographic technique. Sleep 2003 Dec; 26 (8): 986-9
16. Aviv A, Lasker N. A common pathway for essential hypertension and non insulin dependent diabetes mellitus in Blacks: the central role of cytosolic free calcium and sodium-proton exchange. J Vascul Med Biol 1990, 93
17. Ko Y, Sachinidis A, Wieczorek AJ, et al. Insulin enhances angiotensin II induced DNA synthesis in vascular smooth muscle cells of the rat. Clin Invest 1993 May; 71 (5): 379-82
18. Devereux RB, Pini R, Aurigemma GP, et al. Measurement of left ventricular mass: methodology and expertise. J Hypertens 1997 Aug; 15 (8): 801-9
19. Gaasch WH, Zile MR. Left ventricular diastolic dysfunction and diastolic heart failure. Annu Rev Med 2004; 55: 373-94
20. Owan TE, Redfield MM. Epidemiology of diastolic heart failure. Prog Cardiovasc Dis 2005 Mar-Apr; 47 (5): 320-32
21. Ahmed A, Husain A, Love TE, et al. Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods. Eur Heart J 2006 Jun; 27 (12): 1431-9
22. Higashi Y, Sasaki S, Nakagawa K, et al. Effect of obesity on endothelium-dependent nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension. Am J Hypertens 2001 Oct; 14 (10): 1038-45
23. Kato M, Shiode N, Yamagata Matsuura H, et al. Coronary segmental responses to acetylcholine and bradykinin in patients with atherosclerotic risk factors. Am J Cardiol 1997 Sep 15; 80 (6): 751-5
24. Van Guilder GP, Hoetzer GL, Dengel DR, et al. Impaired endothelium-dependent vasodilation in normotensive and normoglycemic obese adult humans. J Cardiovasc Pharmacol 2006 Feb; 47 (2): 310-3
25. Kim JA, Montagnani M, Koh KK, et al. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006 Apr; 113 (15): 1888-904
26. Cersosimo E, DeFronzo RA. Insulin resistance and endothelial. Diabetes Metab Res Rev 2006 Nov-Dec; 22 (6): 423-36
27. Matson CA, Water MF, Weigle DS. Leptin and the regulation of tf body adiposity: a critical review. Diabetes Rev 1996; 4: 488-508
28. Vasseur F, Lepretre F, Lacquemant C, et al. The genetics of adiponectin. Curr Diab Rep 2003 Apr; 3 (2): 151-8
29. Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002 Nov; 8 (11): 1288-95
30. Ekmekci H, Ekmekci OB. The role of adiponectin in atherosclerosis and thrombosis. Clin Appl Thromb Hemost 2006 Apr; 12 (2): 163-8
31. Im JA, Kim SH, Lee JW, et al. The hormone plasma concentration in patients with coronary artery disease are significantly lower than in subjects without coronary artery disease. Metabolism 2006 Nov; 55 (11): 1546-5
32. Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1995 Sep 1; 92 (5): 1355-74
33. Valle M, Martos R, Gascon F, et al. Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. Diabetes Metab 2005 Feb; 31 (1): 55-62
34. Jovinge S, Hamsten A, Tornvall P, et al. Evidence for a role of tumor necrosis factor alpha in disturbances of triglyceride and glucose metabolism predisposing to coronary heart disease. Metabolism 1998; 47 (1): 113-8
35. Karaduman M, Sengul A, Oktenli C, et al. Tissue levels of adiponectin, tumour necrosis factor-alpha, soluble intercellular adhesion molecule-1 and heart-type fatty acid-binding protein in human coronary atherosclerotic plaques. Clin Endocrinol (Oxf) 2006; 64 (2): 196-202
36. Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 2005; 69 (1): 29-35
37. McGill JB, Schneider DJ, Arfken CL, et al. Factors responsible for impaired fibrinolysis in obese subjects and NIDDM patients. Diabetes 1994; 43 (1): 104-9
38. Ailhaud G, Fukamizu A, Massiera F, et al. Angiotensinogen, angiotensin II and adipose tissue development. Int J Obes Relat Metab Disord 2000 Nov; 24 Suppl. 4: S33-5