Short-term beneficial effects of methylene blue on kidney damage in septic shock patients

Intensive Care Medicine

Volumn 34, Issue 2, 2008, Pages 350-354

  Heemskerk, Suzanne ^a   Van Haren, Frank M P ^b   Foudraine, Norbert A ^c   Peters, Wilbert H M ^a   Van Der Hoeven, Johannes G ^a   Russel, Frans G M ^a   Masereeuw, Rosalinde ^a   Pickkers, Peter ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b WAIKATO HOSPITAL   (New Zealand)

^c VIECURI MEDICAL CENTER   (Netherlands)

Author keywords

Acute kidney injury; Glutathione S Transferase; Inducible nitric oxide synthase expression; Nitric oxide metabolites

Indexed keywords

GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE P1; METHYLENE BLUE; NORADRENALIN;

AGED; ARTICLE; BACTERIAL INFECTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CREATININE CLEARANCE; FEMALE; HUMAN; INTENSIVE CARE UNIT; KIDNEY INJURY; MALE; MEAN ARTERIAL PRESSURE; SEPTIC SHOCK; URINARY EXCRETION;

AGED; ANALYSIS OF VARIANCE; ENZYME INHIBITORS; FEMALE; GLUTATHIONE TRANSFERASE; HUMANS; KIDNEY FAILURE, ACUTE; MALE; METHYLENE BLUE; NITRIC OXIDE SYNTHASE; PROSPECTIVE STUDIES; SHOCK, SEPTIC; TREATMENT OUTCOME;

EID: 38849189966     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-007-0867-9     Document Type: Article

References (19)

1. Alberti C, Brun-Buisson C, Goodman SV, Guidici D, Granton J, Moreno R, Smithies M, Thomas O, Artigas A, Le G Jr (2003) Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patients. Am J Respir Crit Care Med 168:77-84
2. Schrier RW, Wang W (2004) Acute renal failure and sepsis. N Engl J Med 351:159-169
3. Heemskerk S, Pickkers P, Bouw MP, Draisma A, van der Hoeven JG, Peters WH, Smits P, Russel FG, Masereeuw R (2006) Up-regulation of renal iNOS during human endotoxemia and sepsis is associated with proximal tubule injury. Clin J Am Soc Nephrol 1:853-862
4. Vincent JL, Zhang H, Szabo C, Preiser JC (2000) Effects of nitric oxide in septic shock. Am J Respir Crit Care Med 161:1781-1785
5. Traylor LA, Proksch JW, Beanum VC, Mayeux PR (1996) Nitric oxide generation by renal proximal tubules: role of nitric oxide in the cytotoxicity of lipid A. J Pharmacol Exp Ther 279:91-96
6. Zacharowski K, Berkels R, Olbrich A, Chatterjee PK, Cuzzocrea S, Foster SJ, Thiemermann C (2001) The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock. Crit Care Med 29:1599-1608
7. Mayer B, Brunner F, Schmidt K (1993) Inhibition of nitric oxide synthesis by methylene blue. Biochem Pharmacol 45:367-374
8. Marczin N, Ryan US, Catravas JD (1992) Methylene blue inhibits nitrovasodilator- and endothelium-derived relaxing factor-induced cyclic GMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion. J Pharmacol Exp Ther 263:170-179
9. Kwok ES, Howes D (2006) Use of methylene blue in sepsis: a systematic review. J Intensive Care Med 21:359-363
10. Bagshaw SM, Langenberg C, Haase M, Wan L, May CN, Bellomo R (2007) Urinary biomarkers in septic acute kidney injury. Intensive Care Med, pub ahead of print
11. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29:530-538
12. Kirsch IR, Cohen HJ (1980) Heinz body hemolytic anemia from the use of methylene blue in neonates. J Pediatr 96:276-278
13. Curry S (1982) Methemoglobinemia. Ann Emerg Med 11:214-221
14. Kirov MY, Evgenov OV, Evgenov NV, Egorina EM, Sovershaev MA, Sveinbjornsson B, Nedashkovsky EV, Bjertnaes LJ (2001) Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study. Crit Care Med 29:1860-1867
15. Ortiz PA, Garvin JL (2003) Cardiovascular and renal control in NOS-deficient mouse models. Am J Physiol Regul Integr Comp Physiol 284:R628-R638
16. Masereeuw R, Russel FG (2001) Mechanisms and clinical implications of renal drug excretion. Drug Metab Rev 33:299-351
17. Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271:C1424-C1437
18. Peng Q, Brown SB, Moan J, Nesland JM, Wainwright M, Griffiths J, Dixon B, Cruse-Sawyer J, Vernon D (1993) Biodistribution of a methylene blue derivative in tumor and normal tissues of rats. J Photochem Photobiol B 20:63-71
19. Levin RL, Degrange MA, Bruno GF, Del Mazo CD, Taborda DJ, Griotti JJ, Boullon FJ (2004) Methylene blue reduces mortality and morbidity in vasoplegic patients after cardiac surgery. Ann Thorac Surg 77:496-499