Effects of haloperidol and risperidone on cerebrohemodynamics in drug-naive schizophrenic patients

Journal of Psychiatric Research

Volumn 42, Issue 4, 2008, Pages 328-335

  Lee, Shin Min ^a,b,c   Chou, Yuan Hwa ^d   Li, Min Hui ^a   Wan, Fang Jung ^a,c   Yen, Mao Hsiung ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b Bali Psychiatric Center   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Antipsychotics; Cerebrohemodynamics; Drug nai dotless ve schizophrenia; Transcranial doppler ultrasonography

Indexed keywords

HALOPERIDOL; RISPERIDONE;

ADULT; ARTICLE; BRAIN BLOOD FLOW; CLINICAL ARTICLE; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; DRUG EFFICACY; HEMODYNAMICS; HUMAN; MALE; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; SCHIZOPHRENIA; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; TREATMENT OUTCOME;

ADULT; ANTIPSYCHOTIC AGENTS; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; DOUBLE-BLIND METHOD; FEMALE; HALOPERIDOL; HUMANS; MALE; RISPERIDONE; SCHIZOPHRENIA;

EID: 38849139676     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2007.02.007     Document Type: Article

References (45)

1. Akopov S., and Whitman G.T. Hemodynamic studies in early ischemic stroke: serial transcranial Doppler and magnetic resonance angiography evaluation. Stroke 33 (2002) 1274-1279
2. Alexandrov A.V., Demchuk A.M., Wein T.H., and Grotta J.C. Yield of transcranial Doppler in acute cerebral ischemia. Stroke 30 (1999) 1604-1609
3. Andreasen N.C., Rezai K., Allinger R., Swayze V.W., Flaum M., Kirchner P., et al. Hypofrontality in neuroleptic-nai{dotless}̈ve patients and patients with chronic schizophrenia. Assessment with Xenon 133 single photon emission computed tomography and Tower of London. Archives of General Psychiatry 49 (1992) 943-958
4. Bang O.Y., Cho J.H., Han B.I., Joo I.S., Kim D.I., and Huh K. Transcranial Doppler findings in middle cerebral arterial occlusive disease in relation to degree of stenosis and presence of concomitant stenoses. Journal of Clinical Ultrasound 31 (2003) 142-151
5. Barbui C., and Percudani M. Epidemiological impact of antidepressant and antipsychotic drugs on the general population. Current Opinion in Psychiatry 19 (2006) 405-410
6. Berman I., Merson A., Sison C., Allan E., Schaefer C., Loberboym M., et al. Regional cerebral blood flow changes associated with risperidone treatment in elderly schizophrenia patients: A pilot study. Psychopharmacological Bulletin 32 (1996) 95-100
7. Bovento G., and Lacombe P. Serotonin and the cerebral circulation. In: Phillip J.W. (Ed). The regulation of cerebral blood flow (1993), CRC Press, Boca Raton, Florida
8. Brown S., Inskip H., and Barraclough B. Causes of the excess mortality of schizophrenia. British Journal of Psychiatry 177 (2000) 212-217
9. Buchsbaum M.S., Potkin S.G., Siegel B.V., Lohr J., Katz M., Gottschalk L.A., et al. Striatal metabolic rate and clinical response to neuroleptics in schizophrenia. Archives of General Psychiatry 49 (1992) 966-974
10. Cheng J.J., Ho H., and Chang C.J. Positive and negative syndrome scale (PANSS): establishment and reliability study of a Mandarin Chinese language version. Chinese Psychiatry 10 (1996) 251-258
11. Cohen Z., Bonvento G., Lacombe P., and Hamel E. Serotonin in the regulation of brain microcirculation. Progress in Neurobiology 50 (1996) 335-362
12. Cohen Z., Bouchelet I., Olivier A., Villemure J.G., Ball R., Stanimirovic D.B., et al. Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization. Journal of Cerebral Blood Flow and Metabolism 19 (1999) 908-917
13. Corson P.W., O'Leary D.S., Miller del D., and Andreasen N.C. The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorder: a comparison between the neuroleptic-naïve and medicated states. Biological Psychiatry 52 (2002) 855-862
14. Curkendall S.M., Mo J., Glasser D.B., Rose Stang M., and Jones J.K. Cardiovascular disease in patients with schizophrenia in Saskatchewan, Canada. Journal of Clinical Psychiatry 65 (2004) 715-720
15. DeLisi L.E., Holcomb H.H., Cohen R.M., Pickar D., Carpenter W.T., Morihisa J.M., et al. Positron emission tomography (PET) in schizophrenic patients on and off neuroleptic medication. Journal of Cerebral Blood Flow and Metabolism 5 (1985) 201-206
16. Demchuk A.M., Christou I., Wein T.H., Felberg R.A., Malkoff M., Grotta J.C., et al. Specific transcranial Doppler flow findings related to the presence and site of arterial occlusion. Stroke 31 (2000) 140-146
17. Demchuk A.M., Christou I., Wein T.H., Felberg R.A., Malkoff M., Grotta J.C., et al. Accuracy and criteria for localizing arterial occlusion with transcranial Doppler. Journal of Neuroimage 10 (2000) 1-12
18. Dixon L., Postrado L., and Delahanty J. The association of medial comorbidity in schizophrenia with poor physical and mental health. Journal of Nervous and Mental Disease 187 (1999) 496-502
19. Dixon L., Weiden P., Delahanty J., Goldberg R., Postrado L., Lucksted A., et al. Prevalence and correlates of diabetes in national schizophrenia samples. Schizophrenia Bulletin 26 (2000) 903-912
20. Finkel S., Kozma C., Long S., Greenspan A., Mahmoud R., Baser O., et al. Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascular events versus other antipsychotics. International Psychogeriatrics 17 (2005) 617-629
21. Formiga F., Fort I., Perez-Castejon J.M., Ruiz D., Duaso E., and Riu S. Association between risperidone treatment and cerebrovascular adverse events in elderly patients with dementia. Journal of the American Geriatrics Society 53 (2005) 1446-1448
22. Geraud G., Arne-Bes M.C., Guell A., and Bes A. Reversibility of hemodynamic hypofrontality in schizophrenia. Journal of Cerebral Blood Flow and Metabolism 7 (1987) 9-12
23. Gill S.S., Rochon P.A., Herrmann N., Lee P.E., Sykora K., Gunraj N., et al. Atypical antipsychotic drugs and risk of ischemic stroke: population based retrospective cohort study. British Medical Journal 330 (2005) 445
24. Gur R.E., Gur R.C., Skolnick B.E., Caroff S., Obrist W.D., Resnick S., et al. Brain function in psychiatric disorders, III: regional cerebral blood flow in unmedicated schizophrenics. Archives of General Psychiatry 42 (1985) 329-334
25. Herrmann N., and Lanctot K.L. Do atypical antipsychotic cause stroke?. CNS Drugs 19 (2005) 91-103
26. Herrmann N., Mamdani M., and Lanctot K.L. Atypical antipsychotics and risk of cerebrovascular accidents. American Journal of Psychiatry 161 (2004) 1113-1115
27. Kay S.R., and Sevy S. Pyramidal model of schizophrenia. Schizophrenia Bulletin 16 (1990) 537-545
28. Klingelhofer J., Sander D., and Matzander J. Assessment of functional hemisphere asymmetrical by bilateral simultaneous cerebral blood flow velocity monitoring. Journal of Cerebral Blood Flow and Metabolism 17 (1997) 577-585
29. Knecht S., Henningsen H., and Deppe M. Successive adaptation of both cerebral hemispheres during cured word generation. Neuroreport 7 (1996) 820-824
30. Lee S.M., Yip P.K., Jeng J.S., Lo H.J., and Chang M. Spontaneous oscillations of cerebral blood flow velocity in the middle cerebral arteries of normal subjects and patients with schizophrenia. Psychiatry Research: Neuroimaging 92 (1999) 93-102
31. Lindegaard K.F. Indies of pulsatility. In: Newell D.W., and Aaslid R. (Eds). Transcranial Doppler (1992), Raven Press, New York
32. Liperoti R., Gambassi G., Lapane K.L., Chiang C., Pedone C., Mor V., et al. Cerebrovascular events among elderly nursing home patients treated with conventional or atypical antipsychotics. Journal of Clinical Psychiatry 66 (2005) 1090-1096
33. Mathew R.J. Postural syncope and autoregulation of cerebral blood flow. Biological Psychiatry 40 (1996) 923-926
34. Miller D.D., Andreasen N.C., O'Leary D.S., Watkins G.L., Boles Ponto L.L., and Hichwa R.D. Comparison of the effects of risperidone and haloperidol on regional cerebral blood flow in schizophrenia. Biological Psychiatry 49 (2001) 704-715
35. Newell D.W., Aaslid R., and Lam A. Comparison of flow and velocity during dynamic autoregulation testing in humans. Stroke 25 (1994) 793-797
36. Nilsson A., Risberg J., Johanson M., and Gustafson L. Regional changes of cerebral blood flow during haloperidol therapy in patients with paranoid symptoms. Acta Neurologica Scandinavica 64 suppl (1997) 478-479
37. Osby U., Correia N., Brandt L., Ekbom A., and Sparen P. Time trends in schizophrenia mortality in Stockholm County, Sweden: cohort study. British Medical Journal 321 (2000) 483-484
38. Owega A., Klingelhofer J., Sabri O., Kunert H.J., Albers M., and Sass H. Cerebral blood flow velocity in acute schizophrenic patients. Stroke 29 (1998) 1149-1154
39. Panssant U., Warkentin S., Minthon L., Faldt R., and Edvinsson L. Cortical blood flow during head-up postural change in subjects with orthostatic hypotention. Clinical Autonomic Research 3 (1993) 311-318
40. Paulman R.G., Devous M.D., and Gregory R.R. Hypofrontality and cognitive impairment in schizophrenia: dynamic single-photon tomography and neuropsychological assessment of schizophrenic brain function. Biological Psychiatry 27 (1990) 377-399
41. Percudani M., Barbui C., Fortino I., Tansella M., and Petrovich L. Second-generation antipsychotics and risk of cerebrovascular accidents in the elderly. Journal of Clinical Psychopharmacology 25 (2005) 468-470
42. Razumovsky A.Y., Gillard J.H., Bryan R.N., Hanley D.F., and Oppenheimer S.M. TCD, MRA, and MRI in acute cerebral ischemia. Acta Neurologica Scandinavica 99 (1999) 65-76
43. Ringelstein E.B., Kahlscheuer B., Niggemeyer E., and Otis S.M. Transcranial Doppler sonography: anatomical landmarks and normal velocity values. Ultrasound in Medicine and Biology 16 (1990) 745-761
44. Silvestrini M., Cupini L.M., Matteis M., Troisi E., and Caltagirone C. Bilateral simultaneous assessment of cerebral flow velocity during mental activity. Journal of Cerebral Blood Flow and Metabolism 14 (1994) 643-648
45. Wolkin A., Jaeger J., Brodie J.D., Wolf A.P., Fowler J., Rotrosen J., et al. Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. American Journal of Psychiatry 142 (1985) 564-571