Amelioration of anti-Thy1-glomerulonephritis by PPAR-γ agonism without increase of endothelial progenitor cell homing

American Journal of Physiology - Renal Physiology

Volumn 294, Issue 2, 2008, Pages

  Westerweel, Peter E ^a   Den Ouden, Krista ^a   Nguyen, Tri Q ^a   Goldschmeding, Roel ^a   Joles, Jaap A ^a   Verhaar, Marianne C ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Anti Thy1 glomerulonephritis; Peroxisome proliferator activated receptors; Stem cell

Indexed keywords

FIBRONECTIN; NEPHRIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLASMINOGEN ACTIVATOR INHIBITOR 1; ROSIGLITAZONE; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GLOMERULONEPHRITIS; HISTOPATHOLOGY; KIDNEY FUNCTION; MALE; MICROANEURYSM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT; STEM CELL; UREA BLOOD LEVEL;

EID: 38849135889     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00019.2007     Document Type: Article

References (33)

1. Bagchus WM, Hoedemaeker PJ, Rozing J, Bakker WW. Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies. A sequential histological and ultrastructural study in the rat. Lab Invest 55: 680-687, 1986.
2. Benigni A, Zoja C, Tomasoni S, Campana M, Corna D, Zanchi C, Gagliardini E, Garofano E, Rottoli D, Ito T, Remuzzi G. Transcriptional regulation of nephrin gene by peroxisome proliferator-activated receptor-gamma agonist: molecular mechanism of the antiproteinuric effect of pioglitazone. J Am Soc Nephrol 17: 1624-1632, 2006.
3. Delles C, Klingbeil AU, Schneider MP, Handrock R, Schaufele T, Schmieder RE. The role of nitric oxide in the regulation of glomerular haemodynamics in humans. Nephrol Dial Transplant 19: 1392-1397, 2004.
4. Futamura A, Izumino K, Sugawara H, Nakagawa Y, Inoue H, Takata M. Effects of leukocytosis and macrophage activation on anti-Thy 1.1 glomerulonephritis in the rat. Scand J Urol Nephrol 36: 435-442, 2002.
5. Gensch C, Clever YP, Werner C, Hanhoun M, Bohm M, Laufs U. The PPAR-gamma agonist pioglitazone increases neoangiogenesis and prevents apoptosis of endothelial progenitor cells. Atherosclerosis 192: 67-74, 2007.
6. Gonon AT, Bulhak A, Labruto F, Sjoquist PO, Pernow J. Cardioprotection mediated by rosiglitazone, a peroxisome proliferator-activated receptor gamma ligand, in relation to nitric oxide. Basic Res Cardiol 102: 80-89, 2007.
7. Guan Y, Breyer MD. Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int 60: 14-30, 2001.
8. Haraguchi K, Shimura H, Onaya T. Suppression of experimental crescentic glomerulonephritis by peroxisome proliferator-activated receptor (PPAR) gamma activators. Clin Exp Nephrol 7: 27-32, 2003.
9. Hur J, Yoon CH, Kim HS, Choi JH, Kang HJ, Hwang KK, Oh BH, Lee MM, Park YB. Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 24: 288-293, 2004.
10. Iruela-Arispe L, Gordon K, Hugo C, Duijvestijn AM, Claffey KP, Reilly M, Couser WG, Alpers CE, Johnson RJ. Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis. Am J Pathol 147: 1715-1727, 1995.
11. Lagaaij EL, Cramer-Knijnenburg GF, van Kemenade FJ, van Es LA, Bruijn JA, van Krieken JH. Endothelial cell chimerism after renal transplantation and vascular rejection. Lancet 357: 33-37, 2001.
12. Ma LJ, Marcantoni C, Linton MF, Fazio S, Fogo AB. Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. Kidney Int 59: 1899-1910, 2001.
13. Masuda Y, Shimizu A, Mori T, Ishiwata T, Kitamura H, Ohashi R, Ishizaki M, Asano G, Sugisaki Y, Yamanaka N. Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis. Am J Pathol 159: 599-608, 2001.
14. Miyamoto K, Kitamoto Y, Tokunaga H, Takeya M, Ezaki T, Imamura T, Tomita K. Protective effect of vascular endothelial growth factor/vascular permeability factor 165 and 121 on glomerular endothelial cell injury in the rat. Lab Invest 84: 1126-1136, 2004.
15. Notoya M, Shinosaki T, Kobayashi T, Sakai T, Kurihara H. Intussusceptive capillary growth is required for glomerular repair in rat Thy-1.1 nephritis. Kidney Int 63: 1365-1373, 2003.
16. Panzer U, Schneider A, Guan Y, Reinking R, Zahner G, Harendza S, Wolf G, Thaiss F, Stahl RA. Effects of different PPARgamma-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis. Kidney Int 62: 455-464, 2002.
17. Peters H, Daig U, Martini S, Ruckert M, Schaper F, Liefeldt L, Kramer S, Neumayer HH. NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis. Kidney Int 64: 509-518, 2003.
18. Pistrosch F, Herbrig K, Kindel B, Passauer J, Fischer S, Gross P. Rosiglitazone improves glomerular hyperfiltration, renal endothelial dysfunction, and microalbuminuria of incipient diabetic nephropathy in patients. Diabetes 54: 2206-2211, 2005.
19. Pistrosch F, Herbrig K, Oelschlaegel U, Richter S, Passauer J, Fischer S, Gross P. PPARgamma-agonist rosiglitazone increases number and migratory activity of cultured endothelial progenitor cells. Atherosclerosis 183: 163-167, 2005.
20. Polikandriotis JA, Mazzella LJ, Rupnow HL, Hart CM. Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. Arterioscler Thromb Vasc Biol 25: 1810-1816, 2005.
21. Rookmaaker MB, Smits AM, Tolboom H, Van't WK, Martens AC, Goldschmeding R, Joles JA, Van Zonneveld AJ, Grone HJ, Rabelink TJ, Verhaar MC. Bone-marrow-derived cells contribute to glomerular endothelial repair in experimental glomerulonephritis. Am J Pathol 163: 553-562, 2003.
22. Rookmaaker MB, Tolboom H, Goldschmeding R, Zwaginga JJ, Rabelink TJ, Verhaar MC. Bone-marrow-derived cells contribute to endothelial repair after thrombotic microangiopathy. Blood 99: 1095, 2002.
23. Rookmaaker MB, Verhaar MC, Van Zonneveld AJ, Rabelink TJ. Progenitor cells in the kidney: biology and therapeutic perspectives. Kidney Int 66: 518-522, 2004.
24. Sarafidis PA, Bakris GL. Protection of the kidney by thiazolidinediones: an assessment from bench to bedside. Kidney Int 70: 1223-1233, 2006.
25. Sheu WH, Ou HC, Chou FP, Lin TM, Yang CH. Rosiglitazone inhibits endothelial proliferation and angiogenesis. Life Sci 78: 1520-1528, 2006.
26. Sivarajah A, Chatterjee PK, Patel NS, Todorovic Z, Hattori Y, Brown PA, Stewart KN, Mota-Filipe H, Cuzzocrea S, Thiemermann C. Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury. Am J Nephrol 23: 267-276, 2003.
27. Urbich C, Aicher A, Heeschen C, Dernbach E, Hofmann WK, Zeiher AM, Dimmeler S. Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol 39: 733-742, 2005.
28. van Goor H, Albrecht EW, Heeringa P, Klok PA, van der Horst ML, de Jager-Krikken A, Bakker WW, Moshage H. Nitric oxide inhibition enhances platelet aggregation in experimental anti-Thy-1 nephritis. Nitric Oxide 5: 525-533, 2001.
29. Verhaar MC, Rabelink TJ. Endothelial function: strategies for early intervention. Cardiovasc Drugs Ther 12, Suppl 1: 125-134, 1998.
30. Wada Y, Morioka T, Oyanagi-Tanaka Y, Yao J, Suzuki Y, Gejyo F, Arakawa M, Oite T. Impairment of vascular regeneration precedes progressive glomerulosclerosis in anti-Thy 1 glomerulonephritis. Kidney Int 61: 432-443, 2002.
31. Wang CH, Ciliberti N, Li SH, Szmitko PE, Weisel RD, Fedak PW, Al Omran M, Cherng WJ, Li RK, Stanford WL, Verma S. Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy. Circulation 109: 1392-1400, 2004.
32. Wang Y, Kramer S, Loof T, Martini S, Kron S, Kawachi H, Shimizu F, Neumayer HH, Peters H. Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis. Kidney Int 68: 47-61, 2005.
33. Werner C, Kamani CH, Gensch C, Bohm M, Laufs U. The PPAR-γ agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance. Diabetes. 56: 2609-2615, 2007.