Candidemia and candiduria in critically ill patients admitted to intensive care units in France: Incidence, molecular diversity, management and outcome

Intensive Care Medicine

Volumn 34, Issue 2, 2008, Pages 292-299

  Bougnoux, Marie Elisabeth ^a,b,c,d   Kac, Guillaume ^b,e   Aegerter, Philippe ^b,f   D'Enfert, Christophe ^c   Fagon, Jean Yves ^b,d,e   Amrein, C ^e   Bellenfant, F ^e   Novara, A ^e   Lavarde, V ^e   Auburtin, M ^g   Paugam Burtz, C ^g   Chochillon, C ^g   Costa De Beauregard, M A ^h   Bizet, J ^h   Fulgencio, J P ^h   Boudaoud, S ⁱ   Lacroix, C ⁱ   Moreau, D ⁱ   Cerf, C ^j   Bretagne, S ^j   Mamzer, M F ^a   Challier, S ^a   Charpentier, J ^k   Lebreton, F ^k   Yera H ^k   Clair, B ^l   Loubert, G ^l   Ronco, E ^l   Cornet, M ^m   Rabbat, A ^m   Datry, A ⁿ   Leblond, V ⁿ   Dumenil, A S ^o   Ingrand, D ^o   Jacobs, F ^o   Guerin J M ^p   Mateo, J ^p   Riahi, J ^p   Guesnon, P ^f   Page, B ^f   Mory, E ^q   Ollivier, J M ^q   Poirot, J L ^q   more..

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^c INSTITUT PASTEUR   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^f HÔPITAL AMBROISE PARÉ   (France)

^g BICHAT HOSPITAL   (France)

^h HÔPITAL TENON   (France)

ⁱ SAINT LOUIS HOSPITAL   (France)

^j HENRI MONDOR HOSPITAL   (France)

^k Hôpital Tenon ^*  (France)

^l RAYMOND POINCARÉ HOSPITAL   (France)

^m HÔTEL DIEU   (France)

ⁿ PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^o HÔPITAL ANTOINE BÉCLÈRE   (France)

^p HÔPITAL LARIBOISIÈRE   (France)

^q HÔPITAL SAINT ANTOINE   (France)

more..

Author keywords

Candidemia; Candiduria; Critically ill patients; Molecular typing; Nosocomial infections

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; CASPOFUNGIN; FLUCONAZOLE; FLUCYTOSINE; ITRACONAZOLE; VORICONAZOLE;

ARTICLE; BLOOD SAMPLING; CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDEMIA; CANDIDIASIS; CANDIDURIA; CRITICALLY ILL PATIENT; DISEASE TRANSMISSION; DRUG SENSITIVITY; FEMALE; FRANCE; HOSPITAL; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MORBIDITY; MULTILOCUS SEQUENCE TYPING; SEPSIS; URINALYSIS;

AGED; ANTIFUNGAL AGENTS; APACHE; CANDIDA; CANDIDIASIS; CHI-SQUARE DISTRIBUTION; CRITICAL ILLNESS; CROSS INFECTION; FEMALE; FRANCE; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PROSPECTIVE STUDIES; RISK FACTORS;

EID: 38849127419     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-007-0865-y     Document Type: Article

References (40)

1. Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348:1546-1554
2. Richards MJ, Edwards JR, Culver DH, Gaynes RP, the National Nosocomial Infections Surveillance System (1999) Nosocomial infections in medical intensive care units in the United States. Crit Care Med 27:887-892
3. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB (2004) Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39:309-317
4. Pfaller MA, Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20:133-163
5. Eggimann P, Garbino J, Pittet D (2003) Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. Lancet Infect Dis 3:685-702
6. Wenzel RP, Gennings C (2005) Bloodstream infections due to Candida species in the intensive care unit: identifying especially high-risk patients to determine prevention strategies. Clin Infect Dis 41 Suppl 6:S389-393
7. Zaoutis TE, Argon J, Chu J, Berlin JA, Walsh TJ, Feudtner C (2005) The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis. Clin Infect Dis 41:1232-1239
8. Gudlaugsson O, Gillespie S, Lee K, Vande Berg J, Hu J, Messer S, Herwaldt L, Pfaller M, Diekema D (2003) Attributable mortality of nosocomial candidemia, revisited. Clin Infect Dis 37:1172-1177
9. Wey SB, Mori M, Pfaller MA, Woolson RF, Wenzel RP (1988) Hospital-acquired candidemia: the attributable mortality and excess length of stay. Arch Intern Med 148:2642-2645
10. Fridkin SK, Jarvis WR (1996) Epidemiology of nosocomial fungal infections. Clin Microbiol Rev 9:499-511
11. Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN, Wenzel RP (1999) Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis 29:239-244
12. Blumberg HM, Jarvis WR, Soucie JM, Edwards JE, Patterson JE, Pfaller MA, Rangel-Frausto MS, Rinaldi MG, Saiman L, Wiblin RT, Wenzel RP (2001) Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. The National Epidemiology of Mycosis Survey. Clin Infect Dis 33:177-186
13. Harris AD, Castro J, Sheppard DC, Carmeli Y, Samore MH (1999) Risk factors for nosocomial candiduria due to Candida glabrata and Candida albicans. Clin Infect Dis 29:926-928
14. Kauffman CA (2005) Candiduria. Clin Infect Dis 41 Suppl 6:S371-376
15. Kauffman CA (2006) Fungal infections. Proc Am Thorac Soc 3:35-40
16. Pappas PG, Andes D, Schuster M, Hadley S, Rabkin J, Merion RM, Kauffman CA, Huckabee C, Cloud GA, Dismukes WE, Karchmer AW (2006) Invasive fungal infections in low-risk liver transplant recipients: a multi-center prospective observational study. Am J Transplant 6:386-391
17. Bougnoux ME, Morand S, d'Enfert C (2002) Usefulness of multilocus sequence typing for characterization of clinical isolates of Candida albicans. J Clin Microbiol 40:1290-1297
18. Le Gall JR, Lemeshow S, Saulnier F (1993) A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957-2963
19. Brun-Buisson C, Abrouk F, Legrand P, Huet Y, Larabi S, Rapin M (1987) Diagnosis of central venous catheter-related sepsis. Critical level of quantitative tip cultures. Arch Intern Med 147:873-877
20. Chryssanthou E, Cuenca-Estrella M (2002) Comparison of the Antifungal Susceptibility Testing Subcommittee of the European Committee on Antibiotic Susceptibility Testing proposed standard and the E-test with the NCCLS broth microdilution method for voriconazole and caspofungin susceptibility testing of yeast species. J Clin Microbiol 40:3841-3844
21. Rex JH, Pfaller MA, Galgiani JN, Bartlett MS, Espinel-Ingroff A, Ghannoum MA, Lancaster M, Odds FC, Rinaldi MG, Walsh TJ, Barry AL (1997) Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and candida infections. Subcommittee on Antifungal Susceptibility Testing of the National Committee for Clinical Laboratory Standards. Clin Infect Dis 24:235-247
22. Pfaller MA, Diekema DJ, Rex JH, Espinel-Ingroff A, Johnson EM, Andes D, Chaturvedi V, Ghannoum MA, Odds FC, Rinaldi MG, Sheehan DJ, Troke P, Walsh TJ, Warnock DW (2006) Correlation of MIC with outcome for Candida species tested against voriconazole: analysis and proposal for interpretive breakpoints. J Clin Microbiol 44:819-826
23. Deresinski SC, Stevens DA (2003) Caspofungin. Clin Infect Dis 36:1445-1457
24. Pujol C, Pfaller M, Soll DR (2002) Ca3 fingerprinting of Candida albicans bloodstream isolates from the United States, Canada, South America, and Europe reveals a European clade. J Clin Microbiol 40:2729-2740
25. Bougnoux ME, Aanensen DM, Morand S, Theraud M, Spratt BG, d'Enfert C (2004) Multilocus sequence typing of Candida albicans: strategies, data exchange and applications. Infect Genet Evol 4:243-252
26. Blignaut E, Pujol C, Lockhart S, Joly S, Soll DR (2002) Ca3 fingerprinting of Candida albicans isolates from human immunodeficiency virus-positive and healthy individuals reveals a new clade in South Africa. J Clin Microbiol 40:826-836
27. Richet H, Roux P, Des Champs C, Esnault Y, Andremont A (2002) Candidemia in French hospitals: incidence rates and characteristics. Clin Microbiol Infect 8:405-412
28. Almirante B, Rodriguez D, Park BJ, Cuenca-Estrella M, Planes AM, Almela M, Mensa J, Sanchez F, Ayats J, Gimenez M, Saballs P, Fridkin SK, Morgan J, Rodriguez-Tudela JL, Warnock DW, Pahissa A (2005) Epidemiology and predictors of mortality in cases of Candida bloodstream infection: results from population-based surveillance, barcelona, Spain, from 2002 to 2003. J Clin Microbiol 43:1829-1835
29. Alvarez-Lerma F, Nolla-Salas J, Leon C, Palomar M, Jorda R, Carrasco N, Bobillo F (2003) Candiduria in critically ill patients admitted to intensive care medical units. Intensive Care Med 29:1069-1076
30. Garbino J, Lew DP, Romand JA, Hugonnet S, Auckenthaler R, Pittet D (2002) Prevention of severe Candida infections in nonneutropenic, high-risk, critically ill patients: a randomized, double-blind, placebo-controlled trial in patients treated by selective digestive decontamination. Intensive Care Med 28:1708-1717
31. Kauffman CA, Vazquez JA, Sobel JD, Gallis HA, McKinsey DS, Karchmer AW, Sugar AM, Sharkey PK, Wise GJ, Mangi R, Mosher A, Lee JY, Dismukes WE (2000) Prospective multicenter surveillance study of funguria in hospitalized patients. The National Institute for Allergy and Infectious Diseases (NIAID) Mycoses Study Group. Clin Infect Dis 30:14-18
32. Blot SI, Vandewoude KH, Hoste EA, Colardyn FA (2002) Effects of nosocomial candidemia on outcomes of critically ill patients. Am J Med 113:480-485
33. Cuenca-Estrella M, Rodriguez D, Almirante B, Morgan J, Planes AM, Almela M, Mensa J, Sanchez F, Ayats J, Gimenez M, Salvado M, Warnock DW, Pahissa A, Rodriguez-Tudela JL (2005) In vitro susceptibilities of bloodstream isolates of Candida species to six antifungal agents: results from a population-based active surveillance programme, Barcelona, Spain, 2002-2003. J Antimicrob Chemother 55:194-199
34. Antoniadou A, Torres HA, Lewis RE, Thornby J, Bodey GP, Tarrand JP, Han XY, Rolston KV, Safdar A, Raad II, Kontoyiannis DP (2003) Candidemia in a tertiary care cancer center: in vitro susceptibility and its association with outcome of initial antifungal therapy. Medicine (Baltimore) 82:309-321
35. Almirante B, Rodriguez D, Cuenca-Estrella M, Almela M, Sanchez F, Ayats J, Alonso-Tarres C, Rodriguez-Tudela JL, Pahissa A (2006) Epidemiology, risk factors, and prognosis of Candida parapsilosis bloodstream infections: case-control population-based surveillance study of patients in Barcelona, Spain, from 2002 to 2003. J Clin Microbiol 44:1681-1685
36. Rodriguez D, Almirante B, Park BJ, Cuenca-Estrella M, Planes AM, Sanchez F, Gene A, Xercavins M, Fontanals D, Rodriguez-Tudela JL, Warnock DW, Pahissa A (2006) Candidemia in neonatal intensive care units: Barcelona, Spain. Pediatr Infect Dis J 25:224-229
37. Vazquez JA, Sanchez V, Dmuchowski C, Dembry LM, Sobel JD, Zervos MJ (1993) Nosocomial acquisition of Candida albicans: an epidemiologic study. J Infect Dis 168:195-201
38. Barchiesi F, Caggiano G, Falconi Di Francesco L, Montagna MT, Barbuti S, Scalise G (2004) Outbreak of fungemia due to Candida parapsilosis in a pediatric oncology unit. Diagn Microbiol Infect Dis 49:269-271
39. Roilides E, Farmaki E, Evdoridou J, Francesconi A, Kasai M, Filioti J, Tsivitanidou M, Sofianou D, Kremenopoulos G, Walsh TJ (2003) Candida tropicalis in a neonatal intensive care unit: epidemiologic and molecular analysis of an outbreak of infection with an uncommon neonatal pathogen. J Clin Microbiol 41:735-741
40. Lemaitre N, Sougakoff W, Masmoudi A, Fievet MH, Bismuth R, Jarlier V (1998) Characterization of gentamicin-susceptible strains of methicillin-resistant Staphylococcus aureus involved in nosocomial spread. J Clin Microbiol 36:81-85