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Bauman JD, Das K, Baweja M, Clark A Jr, Boyer P, Shatkin A, Lewi P, Hughes S, Arnold E: Structures of HIV-1 reverse transcriptase complexed with NNRTI TMC278: Conformational and positional adaptability overcomes resistance mutations. Conference on Retroviruses and Opportunistic Infections (2007) 14:Abs 88.
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Pozniak A, Morales-Ramirez J, Mohapi L, Santoscoy M, Chetchotisakd P, Hereygers M, Vanveggel S, Peeters M, Woodfall B, Boven K: 48-Week primary analysis of trial TMC278-C204: TMC278 demonstrates potent and sustained efficacy in ART-naive patients. Conference on Retroviruses and Opportunistic Infections (2007) 14:Abs 144LB.
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An open-label assessment of TMC 125 - a new, next generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance
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Important preliminary data on a drug that will have a role in the management of children and adolescents with key NNRTI resistance mutations, •
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33846017420
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Abs TUAB0104
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Lazzarin A, Queiroz-Telles F, Frank I, Rockstroh J, Walmsley S, De Paepe E, Vangeneugden T, Spinosa-Guzman S, Lefebvre E: TMC114 provides durable viral load suppression in treatment-experienced patients: POWER 1 and 2 combined week 48 analysis. International AIDS Conference (2006) 16:Abs TUAB0104.
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33847041109
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Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-Week results of POWER 1
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A well-designed clinical trial presenting initial encouraging data on the effects of darunavir in treatment-experienced adults, •
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Katlama C, Esposito R, Gatell JM, Goffard JC, Grinsztejn B, Pozniak A, Rockstroh J, Stoehr A, Vetter N, Yeni P, Parys W et al: Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-Week results of POWER 1. AIDS (2007) 21(4):395-402. • A well-designed clinical trial presenting initial encouraging data on the effects of darunavir in treatment-experienced adults.
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33750377735
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TMC114/r is well tolerated in 3-class-experienced patients: Week 24 primary analysis of POWER 1 (TMC114-C213)
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Abs WePeLB6.201
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Grinsztejn B, Arasteh K, Clotet B, Cunha CA, Goffard JC, Guzman SS, Hill A, Molina JM, Tanski C, Walgraeve H: TMC114/r is well tolerated in 3-class-experienced patients: Week 24 primary analysis of POWER 1 (TMC114-C213). International AIDS Society Conference (2005) 3:Abs WePeLB6.201.
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20
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38849166457
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ICAAC , Abs H-1094
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Berger DS, Bellos N, Farthing C, Stryker R, Colson A, Pierone G, Lefebvre E, Cefalone M, Koester A, Van Baelen K, De Pauw M: TMC114/r in 3-class-experienced patients: 24-Wk primary safety analysis of the POWER 2 study (C202). ICAAC (2005) 45:Abs H-1094.
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Darunavir [package insert, Tibotec BVBA, East Bridgewater, NJ, USA (2006):July 30
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Darunavir [package insert]. Tibotec BVBA, East Bridgewater, NJ, USA (2006):July 30.
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22
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33747585514
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Effect of baseline susceptibility and on-treatment mutations on TMC114 and control PI efficacy: Preliminary analysis of data from PI-experienced patients from POWER 1 and POWER 2
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De Meyer S, Hill A, De Baere I, Rimsky L, Azijn H, Van Baelen B, De Paepe E, Vangeneugden T, Lefebvre E, De Béthune MP: Effect of baseline susceptibility and on-treatment mutations on TMC114 and control PI efficacy: Preliminary analysis of data from PI-experienced patients from POWER 1 and POWER 2. Conference on Retroviruses and Opportunistic Infections (2006) 13:Abs 157.
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38849116827
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The PACTG 1020A protocol: Atazanavir with or without ritonavir in HIV-infected infants, children, and adolescents
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24
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33747019824
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+ pediatric patients administered tipranavir/ritonavir: BI 1182.14 and PACTG 1051 study team
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Abs
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+ pediatric patients administered tipranavir/ritonavir: BI 1182.14 and PACTG 1051 study team. Conference on Retroviruses and Opportunistic Infections (2006) 13:Abs 687
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26
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Lazzarin A, Clotet B, Cooper D, Reynes J, Arastéh K, Nelson M, Katlama C, Stellbrink HJ, Delfraissy JF, Lange J, Huson L et al: Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. N Engl J Med (2003) 348(22):2186-2195. •• This paper and reference [25••] present data from TORO 1 and TORO 2, well designed clinical trials examining the effects of a new class of ART among individuals with drug-resistant HIV infection. Difficulties with side effects and administration have made this drug a less attractive option for treatment in children.
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27
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27944473910
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Durable efficacy of enfuvirtide over 48 weeks in heavily treatment- experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials
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33846017420
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Abs TUAB0104
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30
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Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected children
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