SK-126, a synthetic compound, regulates the production of inflammatory cytokines induced by LPS in antigen-presenting cells

Biochemical Pharmacology

Volumn 75, Issue 5, 2008, Pages 1054-1064

  Kang, Kyeongah ^a   Kim, Hyeree ^a   Kim, Keun Il ^a   Yang, Young ^a   Yoon, Do Young ^b   Kim, Joo Hyon ^c   Ryu, Je Ho ^c   Noh, Eun Jung ^c   Jeon, Sun Duck ^c   Lim, Jong Seok ^a  

^a Sookmyung Women's University   (South Korea)

^b Konkuk University   (South Korea)

^c SK Chemicals   (South Korea)

Author keywords

IL 10; Inflammation; LPS; MAPK; Septic shock; TNF

Indexed keywords

2 ETHYL 8 (4 FLUOROPHENYL) 6 METHYL 3,4 DIHYDRO 2H [2,7]NAPHTHYRIDIN 1 ONE; ANTIINFLAMMATORY AGENT; B7 ANTIGEN; GLYCOPROTEIN P 15095; HEXACHLOROPHENE; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; PYRIDINE DERIVATIVE; SK 126; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; BAGG ALBINO MOUSE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFECT; DRUG INHIBITION; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; DENDRITIC CELLS; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NAPHTHYRIDINES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38849090796     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.10.028     Document Type: Article

References (32)

1. Heath W.R., Belz G.T., Behrens G.M., Smith C.M., Forehan S.P., Parish I.A., et al. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol Rev 199 (2004) 9-26
2. Liu Y.J. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 106 (2001) 259-262
3. Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol 6 (2006) 476-483
4. Kapsenberg M.L. Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 3 (2003) 984-993
5. Napolitani G., Rinaldi A., Bertoni F., Sallusto F., and Lanzavecchia A. Selected toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 6 (2005) 769-776
6. Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 5 (2004) 987-995
7. Qin H., Wilson C.A., Lee S.J., Zhao X., and Benveniste E.N. LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia. Blood 106 (2005) 3114-3122
8. Reiling N., Blumenthal A., Flad H.D., Ernst M., and Ehlers S. Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity. J Immunol 167 (2001) 3339-3345
9. Nakahara T., Moroi Y., Uchi H., and Furue M. Differential role of MAPK signaling in human dendritic cell maturation and Th1/Th2 engagement. J Dermatol Sci 42 (2006) 1-11
10. Chi H., Barry S.P., Roth R.J., Wu J.J., Jones E.A., Bennett A.M., et al. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci USA 103 (2006) 2274-2279
11. Kumar S., Boehm J., and Lee J.C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2 (2003) 717-726
12. -/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J Immunol 176 (2006) 5788-5796
13. Shen Z., Reznikoff G., Dranoff G., and Rock K.L. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. J Immunol 158 (1997) 2723-2730
14. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 176 (1992) 1693-1702
15. Loscher C.E., Draper E., Leavy O., Kelleher D., Mills K.H., and Roche H.M. Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. J Immunol 175 (2005) 4990-4998
16. Adams S., O'Neill D.W., and Bhardwaj N. Recent advances in dendritic cell biology. J Clin Immunol 25 (2005) 177-188
17. Murray P.J. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr Opin Pharmacol 6 (2006) 379-386
18. Ahmed S.T., and Ivashkiv L.B. Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways. J Immunol 165 (2000) 5227-5237
19. Xie J., Qian J., Wang S., Freeman III M.E., Epstein J., and Yi Q. Novel and detrimental effects of lipopolysaccharide on in vitro generation of immature dendritic cells: involvement of mitogen-activated protein kinase p38. J Immunol 171 (2003) 4792-4800
20. Park D., Lapteva N., Seethammagari M., Slawin K.M., and Spencer D.M. An essential role for Akt1 in dendritic cell function and tumor immunotherapy. Nat Biotechnol 24 (2006) 1581-1590
21. Agrawal A., Agrawal S., Cao J.N., Su H., Osann K., and Gupta S. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol 178 (2007) 6912-6922
22. Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 (2001) 37-40
23. de Waal Malefyt R., Yssel H., Roncarolo M.G., Spits H., and de Vries J.E. Interleukin-10. Curr Opin Immunol 4 (1992) 314-320
24. - dendritic cell subsets differ in their cytokine production profiles, susceptibilities to transfection, and capacities to direct Th cell differentiation. J Immunol 165 (2000) 3584-3591
25. Staples K.J., Smallie T., Williams L.M., Foey A., Burke B., Foxwell B.M., et al. IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor STAT3. J Immunol 178 (2007) 4779-4785
26. Bettelli E., Das M.P., Howard E.D., Weiner H.L., Sobel R.A., and Kuchroo V.K. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 161 (1998) 3299-3306
27. Foey A.D., Parry S.L., Williams L.M., Feldmann M., Foxwell B.M., and Brennan F.M. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases. J Immunol 160 (1998) 920-928
28. Schlichting C.L., Schareck W.D., Nickel T., and Weis M. Dendritic cells as pharmacological targets for the generation of regulatory immunosuppressive effectors. New implications for allo-transplantation. Curr Med Chem 12 (2005) 1921-1930
29. Bros M., Jahrling F., Renzing A., Wiechmann N., Dang N.A., Sutter A., et al. A newly established murine immature dendritic cell line can be differentiated into a mature state, but exerts tolerogenic function upon maturation in the presence of glucocorticoid. Blood 109 (2007) 3820-3829
30. Wilson H.L., and O'Neill H.C. Murine dendritic cell development: difficulties associated with subset analysis. Immunol Cell Biol 81 (2003) 239-246
31. Hackstein H., and Thomson A.W. Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol 4 (2004) 24-34
32. Rutella S., and Lemoli R.M. Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications. Immunol Lett 94 (2004) 11-26