M3 muscarinic receptors as targets for drug development in neurodegenerative disorders

Nature Reviews Drug Discovery

Volumn 7, Issue 2, 2008, Pages

  Dragunow, Mike ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CHOLINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUSCARINIC M3 RECEPTOR; PROTEIN BCL 2;

ALZHEIMER DISEASE; APOPTOSIS; ASTHMA; CELL LINE; CELL PROTECTION; CELL SURVIVAL; DEGENERATIVE DISEASE; DIABETES MELLITUS; DRUG TARGETING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LETTER; NEUROPROTECTION; NONHUMAN; OBESITY; PAIN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; ANIMAL; DRUG DESIGN; METABOLISM; NOTE;

ANIMALS; DRUG DESIGN; HUMANS; NEURODEGENERATIVE DISEASES; RECEPTOR, MUSCARINIC M3;

EID: 38849086584     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2506-c1     Document Type: Letter

References (12)

1. Wess, J., Eglen, R. M. & Gautam, D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nature Rev. Drug Discov. 6, 721-733 (2007).
2. Yan, G. M., Lin, S. Z, Irwin, R. P. & Paul, S. M. Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol. Pharmacol. 47, 248-257 (1995).
3. De Sarno, P. et al. Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition. J. Biol. Chem. 278, 11086-11093 (2003).
4. 3-muscarinic receptor to the anti-apoptotic pathway. Biochem. J. 381, 43-49 (2004).
5. Itano, Y., Ito, A., Uehara, T. & Nomura, Y. Regulation of BCL-2 protein expression in human neuroblastoma SH-SY5Y cells: Positive and negative effects of protein kinases C and A, respectively J. Neurochem. 67, 131-137 (1996).
6. Greenwood, J. M. & Dragunow, M. Muscarinic receptor-mediated phosphorylation of cyclic AMP response element binding protein in human neuroblastoma cells. J. Neurochem. 82, 389-397 (2002).
7. Hirota, K. et al. Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. J. Biol. Chem. 279, 41521-41528 (2004).
8. 2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPα) release in SH-SY5Y cells. J. Biol. Chem. 281, 12722-12728 (2006).
9. 3 subtype muscarinic acetylcholine receptors. Cell. Physiol. Biochem. 16, 163-174 (2005).
10. Walton, M. et al. CREB phosphorylation promotes nerve cell survival. J. Neurochem. 73, 1836-1842 (1999).
11. 4 muscarinic receptor subtypes in Alzheimer's disease. Synapse 26, 341-350 (1997).
12. Slack, B. E., Ma, L. K. & Seah, C. C. Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-α converting enzyme. Biochem. J. 357, 787-794 (2001).