Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract

Pharmacology

Volumn 81, Issue 2, 2008, Pages 104-109

  Chetty, Navinisha ^a   Irving, Helen R ^a   Coupar, Ian M ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

5 HT3 agonist; 5 HT3 receptors; Guinea pig intestine; MKC 733; Mouse intestine; Rat intestine

Indexed keywords

5 FLUORO 2 METHOXY 1H INDOLE 3 CARBOXYLIC ACID 1 [2 (METHYLSULFONAMIDO)ETHYL] 4 PIPERIDINYLMETHYL ESTER; METHYSERGIDE; ONDANSETRON; PUMOSETRAG; SEROTONIN; SEROTONIN 3 RECEPTOR;

ANIMAL TISSUE; ARTICLE; ASCENDING COLON; CONTROLLED STUDY; DESCENDING COLON; DIGESTIVE SYSTEM; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; FEMALE; GUINEA PIG; ILEUM; IN VITRO STUDY; INTESTINE CONTRACTION; JEJUNUM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL TRACT; GUINEA PIGS; MALE; MICE; PYRIDINES; QUINUCLIDINES; RATS; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN AGONISTS; SPECIES SPECIFICITY;

EID: 38749148446     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000109984     Document Type: Article

References (11)

1. Yano T, Yamazaki S, Tobe A: Effects of MKC-733, a new prokinetic agent, on the gastrointestinal tract (abstract). Digestion 1998;59:737.
2. Yano T, Kuwahara A, Yamakazi S: The effects of MKC-733, a new potent 5-HT 3 receptor agonist, on ion transport of guinea pig distal colon (abstract). Jpn J Pharmacol 1996;71:109.
3. Yamazaki S, Yano T, Ogawa S, Tobe A: Effects of MKC-733, a new prokinetic compound, on gastrointestinal motility in rats and dogs (abstract). Jpn J Pharmacol 1995;67:189.
4. Coleman NS, Marciani L, Blackshaw E, Wright J, Parker M, Yano T, Yamazaki S, Chan PQ, Wilde K, Gowland PA, Perkins AC, Spiller RC: Effect of a novel 5-HT 3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther 2003;18:1039-1048.
5. Fujita T, Yokota S, Sawada M, Majima M, Ohtani Y, Kumagai Y: Effect of MKC-733, a 5-HT receptor partial agonist, on bowel motility and symptoms in subjects with constipation: an exploratory study. J Clin Pharm Ther 2005;30:611-622.
6. Yamazaki S, Yano T, Tobe A: Species difference in the intrinsic activity of MKC-733 for the 5-HT 3 receptor (abstract). Jpn J Pharmacol 1996;71:62.
7. 4 receptor antagonist. Br J Pharmacol 1994;113:120P.
8. 3 receptors in the rat and mouse intestinal tract: a comparative study. Br J Pharmacol 2006;148:1012-1021.
9. 3 receptor cDNA and its splice variants from guinea pig. Mol Pharmacol 1998;53:202-212.
10. Sakurai-Yamashita Y, Yamashita K, Kaibara M, Enjoji A, Kanematsu T, Taniyama K: Differential distribution of 5-hydroxytryptamine3 receptor in the colon between human and guinea pig. Chin J Physiol 1999;42:195-198.
11. De Ponti F: Pharmacology of serotonin: what a clinician should know. Gut 2004;53:1520-1535.