Case 1-2008 One Institution's Decreasing Use of Aprotinin During Cardiac Surgery in 2006

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 22, Issue 1, 2008, Pages 139-146

  Strouch, Zaneta Y ^a   Chaney, Mark A ^a   Augoustides, John G T ^b   Spiess, Bruce D ^c  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

aprotinin; blood product use; cardiac surgery

Indexed keywords

APROTININ;

ARTICLE; DATA ANALYSIS; DEMOGRAPHY; DRUG UTILIZATION; ERYTHROCYTE; HEART SURGERY; HUMAN; MEDICAL RESEARCH; PRIORITY JOURNAL; RISK ASSESSMENT;

APROTININ; CARDIAC SURGICAL PROCEDURES; FEMALE; HEMOSTATICS; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SERINE PROTEINASE INHIBITORS;

EID: 38749135828     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2007.11.005     Document Type: Article

References (42)

1. Laupacis A., and Fergusson D. Drugs to minimize perioperative blood loss in cardiac surgery: Meta analysis using perioperative blood transfusion as the outcome. Anesth Analg 85 (1997) 1258-1267
2. Sedrakyan A., Treasure T., and Elefteriades J.A. Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials. J Thorac Cardiovasc Surg 128 (2004) 442-448
3. Mangano D.T., Tudor I.C., Dietzel C., and Multicenter Study of Perioperative Ischemia Research Group; Ischemic Research and Education Foundation. The risk associated with aprotinin in cardiac surgery. N Engl J Med 354 (2006) 353-365
4. Bayer HealthCare. Trasylol (aprotinin injection) prescribing information. www.trasylol.com Accessed December 27, 2007
5. Alderman E.L., Levy J.H., Rich J.B., et al. Analyses of coronary graft patency after aprotinin use: Results from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial. J Thorac Cardiovasc Surg 116 (1998) 716-730
6. Gott J.P., Cooper W.A., and Schmidt F.E. Modifying risk for extracorporeal circulation: trial of four antiinflammatory strategies. Ann Thorac Surgery 66 (1998) 747-754
7. Diprose P., Herbertson M.J., O'Shaughnessy D., et al. Reducing allogeneic transfusion in cardiac surgery: A randomized double-blind placebo-controlled trial of antifibrinolytic therapies used in addition to intraoperative cell salvage. Br J Anaesth 94 (2005) 271-278
8. Chaney M. The risk associated with aprotinin in cardiac surgery (literature review). Society of Cardiovascular Anesthesiologists Newsletter 5 (2006) 5
9. SCA. Aprotinin debate ends in stalemate. Anesth News 33 (2007) 33-34
10. American Cancer Society. Possible risks of blood product transfusions. http://www.cancer.org Accessed December 27, 2007
11. Spiess B.D., Royston D., Levy J.H., et al. Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes. Transfusion 44 (2004) 1143-1148
12. Bucerius J., Gummert J.F., Borger M.A., et al. Stroke after cardiac surgery: A risk factor analysis of 16,184 consecutive adult patients. Ann Thorac Surgery 75 (2003) 472-478
13. Harmon D.C., Ghori K.G., Eustace N.P., et al. Aprotinin decreases the incidence of cognitive deficit following CABG and cardiopulmonary bypass: A pilot randomized controlled study. Can J Anaesth 51 (2004) 957-962
14. Vamvakas E., and Carven J. Allogeneic blood transfusion and postoperative duration of mechanical ventilation. Transfusion 41 (2001) 885-892
15. Engoren M.C., Habib R.H., Zacharias A., et al. Effect of blood transfusion on long-term survival after cardiac operation. Ann Thorac Surg 74 (2002) 1180-1186
16. Mangano D.T., Miao Y., Vuylsteke A., et al. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 297 (2007) 471-479
17. Augoustides J. Con: Aprotinin should not be used in cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth 21 (2007) 302-304
18. Brown J.R., Birkmeyer N.J.O., and O'Connor G.T. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 115 (2007) 2801-2813
19. Kincaid E.H., Ashburn D.A., Hoyle J.R., et al. Does the combination of aprotinin and angiotensin-converting enzyme inhibitor cause renal failure after cardiac surgery?. Ann Thorac Surg 80 (2005) 1388-1393
20. Coleman C.I., Rigali V.T., Hammond J., et al. Evaluating the safety implications of aprotinin use: The Retrospective Evaluation of Aprotinin in Cardio Thoracic Surgery (REACTS). J Thorac Cardiovasc Surg 133 (2007) 1547-1552
21. Dietrich W., Busley R., and Kriner M. High-dose aprotinin in cardiac surgery: Is high-dose enough?. An analysis of 8281 cardiac surgical patients treated with aprotinin. Anesth Analg 103 (2006) 1074-1081
22. Stover E.P., Siegel L.C., Parks R., et al. Variability in transfusion practice for coronary artery bypass surgery despite national consensus guidelines: A 24 institution study. Institutions of the Multicenter Study of Perioperative Ischemia Research Group. Anesthesiology 88 (1998) 327-333
23. Ferraris V.A., Ferraris S.P., Saha S.P., and Society of Thoracic Surgeons Blood Conservation Guideline Task Force. Perioperative blood transfusion in cardiac surgery: the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists clinical practice guideline. Ann Thorac Surg 83 (2007) S27-S86
24. Hébert P.C., Wells G., Blajchman M.A., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 340 (1999) 409-417
25. Banbury M.K., Bruzzio M.E., Rajeswaran J., et al. Transfusion increases the risk of postoperative infection after cardiac surgery. J Am Coll Surg 202 (2006) 131-138
26. Leal-Noval S.R., Rincon-Ferrari M.D., Garcia-Curiel A., et al. Transfusion of blood components and postoperative infection in patients undergoing heart surgery. Chest 119 (2001) 1461-1468
27. Habib R.H., Zacharias A., Schwann T.A., et al. Role of hemodilutional anemia and transfusion during cardiopulmonary bypass in renal injury after coronary revascularization: Implications on operative outcome. Crit Care Med 33 (2005) 1749-1756
28. Rao S.V., Jollis J.G., Harrington R.A., et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA 292 (2004) 1555-1562
29. Koch C.G., Khandwala F., Li L., et al. Persistent effect of red cell transfusion on health-related quality of life after cardiac surgery. Ann Thorac Surg 82 (2006) 13-20
30. Moehnle P., Snyder-Ramas S.A., Weng Y.-S., et al. Morbid risks of unnecessary red blood cell transfusion in stable coronary artery bypass graft patients. Blood 106 (2005) 427 abstract
31. Snyder-Ramos S.A., Moehnle P., Weny Y.-S., et al. Ongoing variability in transfusion practices in cardiac surgery despite established guidelines. Blood 106 (2005) 947 abstract
32. Kulier A., Levin J., Moser R., et al. Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgery. Circulation 116 (2007) 471-479
33. Kress D.C., Aronson S., McDonald M.I., et al. Positive heparin-platelet factor 4 antibody complex and cardiac surgical outcomes. Ann Thorac Surg 83 (2007) 1737-1743
34. Nakamoto H., Shimada Y., Kanno T., et al. Role of platelet factor 4-heparin complex antibody (HIT antibody) in the pathogenesis of thrombotic episodes in patients on hemodialysis. Hemodial Int 9 suppl 1 (2005) S2-S7
35. Lu S. Memorandum Department of Health and Human Services Public Health Service Food and Drug Administration Center for Drug Evaluation and Research. PID# D060054 (2006)
36. DeFoe G.R., Ross C.S., Olmstead E.M., et al. Lowest hematocrit on bypass and adverse outcomes associated with coronary artery bypass grafting. Northern New England Cardiovascular Disease Study Group. Ann Thorac Surg 71 (2001) 769-776
37. Habib R.H., Zacharias A., Schwann T.A., et al. Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: Should current practice be changed?. J Thorac Cardiovasc Surg 125 (2003) 1438-1450
38. Surgenor S.D., DeFoe G.R., Fellinger M.P., et al. Intraoperative red blood cell transfusion during coronary artery bypass graft surgery increases the risk of postoperative low-output heart failure. Circulation 114 suppl (2006) 43-48
39. Aronson S., Fontes M.L., Miao Y., et al. Risk index for perioperative renal dysfunction/failure: Critical dependence on pulse pressure hypertension. Circulation 115 (2007) 733-742
40. Ott E., Mazer C.D., Tudor I.C., et al. Coronary artery bypass graft surgery-Care globalization: The impact of national care on fatal and nonfatal outcome. J Thorac Cardiovasc Surg 133 (2007) 1242-1251
41. Rana R., Fernandez-Perez E.R., Khan S.A., et al. Transfusion-related acute lung injury and pulmonary edema in critically ill patients: A retrospective study. Transfusion 46 (2006) 1478-1483
42. Khan H., Belsher J., Yilmez M., et al. Fresh frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest 131 (2007) 1305-1314