Positive Heparin-Platelet Factor 4 Antibody Complex and Cardiac Surgical Outcomes

Annals of Thoracic Surgery

Volumn 83, Issue 5, 2007, Pages 1737-1743

  Kress, David C ^a   Aronson, Solomon ^b   McDonald, Monica L ^a   Malik, Mohammad I ^a   Divgi, Ajit B ^a   Tector, Alfred J ^a   Downey III, Francis X ^a   Anderson, Alfred J ^a   Stone, Mia ^a   Clancy, Cassandra ^a  

^a ST LUKE S MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; HEPARIN PLATELET FACTOR 4 ANTIBODY;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DEMOGRAPHY; DIABETES MELLITUS; DIALYSIS; FEMALE; HEART SURGERY; HUMAN; INCIDENCE; LABORATORY TEST; MALE; POSTOPERATIVE CARE; PRIORITY JOURNAL; RISK ASSESSMENT; SCREENING; TREATMENT OUTCOME;

AGED; ANTIBODIES; ANTICOAGULANTS; CARDIAC SURGICAL PROCEDURES; FEMALE; HEPARIN; HUMANS; MALE; MIDDLE AGED; PLATELET FACTOR 4; RETROSPECTIVE STUDIES; THROMBOCYTOPENIA; TREATMENT OUTCOME;

EID: 34247217944     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2006.12.011     Document Type: Article

References (22)

1. Warkentin T.E., Levine M.N., Hirsh J., et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 332 (1995) 1330-1335
2. Rice L. Heparin-induced thrombocytopenia: myths and misconceptions (that will cause trouble for you and your patient). Arch Intern Med 164 (2004) 1961-1964
3. Lee D.H., and Warkentin T.E. Frequency of heparin-induced thrombocytopenia. In: Warkentin T.E., and Greinacher A. (Eds). Heparin-induced thrombocytopenia. 3rd ed. (2004), Marcel Dekker Inc, New York, NY 107-148
4. Warkentin T.E., and Greinacher A. Heparin-induced thrombocytopenia and cardiac surgery. Ann Thorac Surg 76 (2003) 2121-2131
5. Warkentin T.E., and Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment, and prevention; the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 3 suppl (2004) 311S-337S
6. Warkentin T.E., Sheppard J.A., Horsewood P., Simpson P.J., Moore J.C., and Kelton J.G. Impact of the patient population on the risk for heparin-induced thrombocytopenia. Blood 96 (2000) 1703-1708
7. Mattioli A.V., Bonetti L., Sternieri S., and Mattiloi G. Heparin-induced thrombocytopenia in patients treated with unfractionated heparin: prevalence of thrombosis in a 1 year follow-up. Ital Heart J 1 (2000) 39-42
8. Dyke C.M., Koster A., Veale J.J., Maier G.W., McNiff T., and Levy J.H. Preemptive use of bivalirudin for urgent on-pump coronary artery bypass grafting in patients with potential heparin-induced thrombocytopenia. Ann Thorac Surg 80 (2005) 299-303
9. Bennett-Guerrero E., Slaughter T.F., White W.D., et al. Preoperative anti-PF4/heparin antibody level predicts adverse outcome after cardiac surgery. J Thorac Cardiovasc Surg 130 (2005) 1567-1572
10. Visentin G.P., Malik M., Cyganiak K.A., and Aster R.H. Patients treated with unfractionated heparin during open heart surgery are at high risk to form antibodies reactive with heparin platelet factor 4 complexes. J Lab Clin Med 128 (1996) 376-383
11. Walls J.T., Curtis J.J., Silver D., Boley T.M., Schmaltz R.A., and Nawarawong W. Heparin-induced thrombocytopenia in open heart surgical patients; sequelae of late recognition. Ann Thorac Surg 53 (1992) 787-791
12. Francis J.L., Palmer III G.J., Moroose R., and Drexler A. Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery. Ann Thorac Surg 75 (2003) 17-22
13. Bauer T.L., Arepally G., Konkle B.A., et al. Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. Circulation 95 (1997) 1242-1246
14. Pouplard C., May M.A., Iochmann S., et al. Antibodies to platelet factor 4-heparin after cardiopulmonary bypass in patients anticoagulated with unfractionated heparin or a low-molecular-weight heparin: clinical implications for heparin-induced thrombocytopenia. Circulation 99 (1999) 2530-2536
15. Trossaert M., Gaillard A., Commin P.L., Amiral J., Vissac A.M., and Fressinaud E. High incidence of anti-heparin/platelet factor 4 antibodies after cardiopulmonary bypass surgery. Br J Haematol 101 (1998) 653-655
16. Williams R.T., Damaraju L.V., Mascelli M.A., et al. Anti-platelet factor 4/heparin antibodies: an independent predictor of 30-day myocardial infarction after acute coronary ischemic syndromes. Circulation 107 (2003) 2307-2312
17. Woodhams B.J., and Grimaux M. Detection of PF4-heparin auto-antibodies by ELISA. Thromb Haemost 82 (1999) 157-158
18. Warkentin T.E., and Kelton J.G. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 344 (2001) 1286-1292
19. Pouplard C., Amiral J., Borg J.Y., Laporte-Simitsidis S., Delahousse B., and Gruel Y. Decision analysis for use of platelet aggregation test, carbon 14-serotonin release assay, and heparin-platelet factor 4 enzyme-linked immunosorbent assay for diagnosis of heparin-induced thrombocytopenia. Am J Clin Pathol 111 (1999) 700-706
20. Frequently-asked questions (data definitions and specifications): Adult Cardiac Surgery Database. Version 2.52.1 FAQ Document. The Society of Thoracic Surgeons Web site. Available at: http://www.sts.org/sections/stsnationaldatabase/datamanagers/adultcardiacdb/support/faq/article2.html. Accessed August 5, 2005.
21. Calaitges J.G., Liem T.K., Spadone D., Nichols W.K., and Silver D. The role of heparin associated antiplatelet antibodies in the outcome of arterial reconstruction. J Vasc Surg 29 (1999) 779-786
22. Kelton J.G., Sheridan D., Santos A., et al. Heparin-induced thrombocytopenia: laboratory studies. Blood 72 (1988) 925-930