Compaction properties, drug release kinetics and fronts movement studies from matrices combining mixtures of swellable and inert polymers: Effect of HPMC of different viscosity grades

International Journal of Pharmaceutics

Volumn 351, Issue 1-2, 2008, Pages 61-73

  Escudero, J J ^a   Ferrero, C ^a   Jimenez Castellanos M R ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Drug delivery system; Hydroxypropyl methylcellulose; Hydroxypropylcellulose methyl methacrylate; Release modulation; Theophylline; Viscosity

Indexed keywords

HYDROXYPROPYLCELLULOSE METHYL METHACRYLATE; HYDROXYPROPYLMETHYLCELLULOSE; METHACRYLIC ACID METHYL ESTER; METHYLCELLULOSE; POLYMER; THEOPHYLLINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DIFFUSION; DRUG RELEASE; PLASTICITY; POROSITY; PRESSURE MEASUREMENT; PRIORITY JOURNAL; TABLET; VISCOSITY; WATER TRANSPORT;

CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; FREEZE DRYING; METHYLCELLULOSE; METHYLMETHACRYLATE; POROSITY; TABLETS; THEOPHYLLINE; VISCOSITY; WATER;

EID: 38749127211     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.09.031     Document Type: Article

References (39)

1. Bettini R., Catellani P.L., Santi P., Massimo G., Peppas N.A., and Colombo P. Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate. J. Control. Release 70 (2001) 383-391
2. Bettini R., Colombo P., Massimo G., Catellani P.L., and Vitali T. Swelling and drug release in hydrogel matrices: polymer viscosity and matrix porosity effects. Eur. J. Pharm. Sci. 2 (1994) 213-219
3. Bolhuis G.K., and Lerk C.F. Compression evaluation of excipients for direct compression. Pharm. Weekbl. 108 (1973) 469-481
4. Bonferoni M.C., Rossi S., Tamayo M., Pedráz J.L., Domínguez-Gil A., and Caramella C. On the employment of λ carrageenan in a matrix system. II. λ carrageenan and hydroxypropylmethylcellulose mixtures. J. Control. Release 30 (1994) 175-182
5. Campos-Aldrete M.E., and Villafuerte-Robles L. Influence of the viscosity grade and the particle size of HPMC on metronidazole release from matrix tablets. Eur. J. Pharm. Biopharm. 43 (1997) 173-178
6. Castellano L., Gurruchaga M., and Goñi I. The influence of drying method on the physical properties of some graft copolymers for drug delivery systems. Carbohyd. Polym. 34 (1997) 83-89
7. Catellani P.L., Vaona G., Plazzi P., and Colombo P. Compressed matrices: formulation and drug release kinetics. Acta Pharm. Technol. 34 (1988) 38-41
8. Colombo P., Bettini R., Máximo G., Catellani P.L., Santi P., and Peppas N.A. Drug diffusion front movement is important in drug release control from swellable matrix tablets. J. Pharm. Sci. 84 (1995) 991-997
9. Colombo P., Bettini R., Santi P., De Ascentiis A., and Peppas N.A. Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport. J. Control. Release 39 (1996) 231-237
10. Colombo P., Catellani P.L., Peppas N.A., Maggi L., and Conte L.U. Swelling characteristics of hydrophilic matrices for controlled release: new dimensionless number to describe the swelling and release behaviour. Int. J. Pharm. 88 (1992) 99-109
11. Colombo P., Conte U., Gazzaniga A., Maggi L., Sangalli M.E., Peppas N.A., and La Manna A. Drug release modulating by physical restriction of matrix swelling. Int. J. Pharm. 63 (1990) 43-48
12. Colombo P., Gazzaniga A., Caramella C., Conte U., and La Manna U.A. In vitro programmable zero-order release drug delivery system. Acta Pharm. Technol. 33 (1987) 15-20
13. Doelker E. Physique de la compression. Intérêt et limite des machines instrumentées pour l'optimisation de la formulation. Pharm. Acta Helv. 53 (1978) 1-7
14. European Pharmacopoeia, fifth ed., 2004. Council of Europe, Strasbourg, France.
15. Feely L., and Davis S. The influence of polymeric excipients on drug release from hydroxypropylmethylcellulose matrices. Int. J. Pharm. 44 (1988) 131-139
16. Ferrero C., Bravo I., and Jiménez-Castellanos M.R. Drug release kinetics and fronts movement studies from methyl methacrylate (MMA) copolymer matrix tablets: effect of copolymer type and matrix porosity. J. Control. Release 92 (2003) 69-82
17. Ferrero C., and Jiménez-Castellanos M.R. The influence of carbohydrate nature and drying methods on the compaction properties and pore structure of new methyl methacrylate copolymers. Int. J. Pharm. 248 (2002) 157-171
18. Ferrero C., Muñoz-Ruiz A., and Jiménez-Castellanos M.R. Fronts movement as a useful tool for hydrophilic matrix release mechanism elucidation. Int. J. Pharm. 202 (2000) 21-28
19. Ford J.L., Rubinstein M.H., and Hogan J.E. Formulation of sustained release promethazine hydrochloride tablets using hydroxypropyl-methylcellulose matrices. Int. J. Pharm. 24 (1985) 327-338
20. Ford J.L., Mitchell K., Rowe P., Armstrong D.J., Elliot P.N.C., Rostron C., and Hogan J.E. Mathematical modelling of drug release hydroxypropylmethylcellulose matrices: effect of temperature. Int. J. Pharm. 71 (1991) 95-104
21. Grassi M., Zema L., Sangalli M.E., Maroni A., Giordano F., and Gazzaniga A. Modeling of drug release from partially coated matrices made of a high viscosity HPMC. Int. J. Pharm. 276 (2004) 107-114
22. Heng P.W.S., Chan L.W., Easterbrook M.G., and Li X. Investigation of the influence of mean HPMC particle size and number of polymer particles on the release of aspirin from swellable hydrophilic matrix tablets. J. Control. Release 76 (2001) 39-49
23. Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52 (1963) 1145-1149
24. Järvinen M.J., and Juslin M.J. Evaluation of force-displacement measurements during one-sided powder compaction in a die; the influence of friction with the die wall and of the diameter of punches and die on upper and lower punch pressure. Powder Technol. 28 (1981) 115
25. Kiortsis S., Kachrimanis K., Broussali T., and Malamataris S. Drug release from tableted wet granulations comprising cellulosic (HPMC or HPC) and hydrophobic component. Eur. J. Pharm. Biopharm. 59 (2005) 73-83
26. Korsmeyer R.W., Gurny R., Doelker E., Buri P., and Peppas N.A. Mechanisms of solute release from porous hydrophilic polymers. Int. J. Pharm. 15 (1983) 25-35
27. Losi E., Bettini R., Santi P., Sonvico F., Colombo G., Lofthus K., Colombo P., and Peppas N.A. Assemblage of novel release modules for the development of adaptable drug delivery systems. J. Control. Release 111 (2006) 212-218
28. Lotfipour F., Nokhodchi A., Saeedi M., Norouzi-Sani S., Sharbafi J., and Siahi-Shadbad M.R. The effect of hydrophilic and lipophilic polymers and fillers on the release rate of atenolol from HPMC matrices. Il Farmaco 59 (2004) 819-825
29. Muñoz-Ruiz A., Gallego R., del Pozo M., Jiménez-Castellanos M.R., and Domínguez-Abascal J. A comparison of three methods of estimating displacement on an instrumental single punch tablet machine. Drug Dev. Ind. Pharm. 21 (1995) 215-227
30. Nellore R.V., Rekhi G.S., Hussain A.S., Tillman Ll.G., and Augsburger L.L. Development of metoprolol tartrate extended-release matrix tablet formulations for regulatory policy consideration. J. Control. Release 50 (1998) 247-256
31. Peppas N.A., and Sahlin J.J. A simple equation for the description of solute release. III. Coupling of diffusion and relaxation. Int. J. Pharm. 57 (1989) 169-172
32. Reynolds T.D., Gehrke S.H., Hussain A.S., and Shenouda L.S. Polymer erosion and drug release characterization of hydroxypropyl methylcellulose matrices. J. Pharm. Sci. 87 (1998) 1115-1123
33. Ritger P.I., and Peppas N.A. A simple equation for description of solute release. I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J. Control. Release 5 (1987) 23-26
34. Salomen J.L., Doelker E., and Buri P. Importance de la technologie et de la formulation pour le mechanisme de liberation du chlorure de potassium contenu dans des matrices hydrophiles. Pharm. Acta Helv. 54 (1979) 82-85
35. Tahara K., Yamamoto K., and Nishihata T. Overall mechanism behind matrix sustained release (SR) tablets prepared with hydroxypropyl methylcellulose 2910. J. Control. Release 35 (1995) 59-66
36. Takka S., Rajbhandavi S., and Sakr A. Effect of anionic polymers on the release of propanolol hydrochloride from matrix tablets. Eur. J. Pharm. Biopharm. 52 (2001) 75-82
37. Traconis N., Rodríguez R., Campo M.E., and Villafuerte L. Influence of admixed polymers on the metronidazole release from hydroxypropyl methylcellulose matrix tablets. Pharm. Acta Helv. 72 (1997) 131-138
38. Vázquez M.J., Casalderrey M., Duro R., Gómez-Amoza J.L., Martínez-Pacheco R., Souto C., and Concheiro A. Ateneolol release from hydrophilic matrix tablets with hydroxypropylmethylcellulose (HPMC) mixtures as gelling agent: effects of the viscosity of the HPMC mixture. Eur. J. Pharm. Biopharm. 4 (1996) 39-48
39. Walker C.V., and Wells J.L. Rheological synergism between ionic and no ionic cellulose gums. Int. J. Pharm. 11 (1982) 309-322