Development of a two-step chromatography procedure that allows the purification of a high-purity anti-histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity

Biomedical Chromatography

Volumn 22, Issue 1, 2008, Pages 13-19

  Shimada, Yayoi ^a   Goto, Takeshi ^a   Kawamoto, Seiji ^b   Kiso, Takashi ^b   Katayama, Akiko ^b   Yamanaka, Yasushi ^b   Aki, Tsunehiro ^b   Chiang, Kuei Chen ^a   Nakano, Toshiaki ^c   Goto, Shigeru ^c,d   Chen, Chao Long ^c   Ohmori, Naoya ^a   Ono, Kazuhisa ^b   Sato, Shuji ^a  

^a JOSAI INTERNATIONAL UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d Iwao Hospital   (Japan)

Author keywords

Anion exchange chromatography; Gel filtration chromatography; Immunosuppressant; Monoclonal antibody; Organ transplantation

Indexed keywords

ANIMALS; GEL PERMEATION CHROMATOGRAPHY; PURIFICATION;

ANALYTICAL TOOL; ANION EXCHANGE CHROMATOGRAPHY; GEL-FILTRATION CHROMATOGRAPHY; HIGH PURITY; HISTONE H1; IMMUNOSUPPRESSANTS; MODEL ANIMALS; POLYCLONAL; SIDE EFFECT; STRONG ANION-EXCHANGE CHROMATOGRAPHY;

MONOCLONAL ANTIBODIES;

HISTONE ANTIBODY; HISTONE H1; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; GEL FILTRATION CHROMATOGRAPHY; GRAFT SURVIVAL; HYBRIDOMA; IMMUNOSUPPRESSIVE TREATMENT; MALE; NONHUMAN; ORGAN TRANSPLANTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN PURIFICATION; RAT; SUPERNATANT;

ANIMALIA;

EID: 38749120900     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.887     Document Type: Article

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