Energetic effects for observed and unobserved HIV-1 reverse transcriptase mutations of residues L100, V106, and Y181 in the presence of nevirapine and efavirenz

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 3, 2008, Pages 969-972

  Kroeger Smith, Marilyn B ^a   Rader, Lenea H ^a   Franklin, Amanda M ^a   Taylor, Emily V ^a   Smith, Katie D ^a   Smith Jr , Richard H ^a   Tirado Rives, Julian ^b   Jorgensen, William L ^b  

^a MCDANIEL COLLEGE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Computer; Drugs; HIV; Modeling; Resistance

Indexed keywords

EFAVIRENZ; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE;

ARTICLE; CODON; CRYSTAL STRUCTURE; DRUG BINDING; GENE MUTATION; HUMAN; MONTE CARLO METHOD;

AMINO ACID SUBSTITUTION; ANTI-HIV AGENTS; BENZOXAZINES; COMPUTER SIMULATION; DRUG RESISTANCE; DRUG RESISTANCE, VIRAL; HIV REVERSE TRANSCRIPTASE; HUMANS; LEUCINE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION, MISSENSE; NEVIRAPINE; REVERSE TRANSCRIPTASE INHIBITORS; THERMODYNAMICS; TYROSINE; VALINE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 38749116964     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.033     Document Type: Article

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