Prognostic Implications of Lymphangiogenesis in Muscle-Invasive Transitional Cell Carcinoma of the Bladder

European Urology

Volumn 53, Issue 3, 2008, Pages 571-580

  Fernández, Mario I ^a   Bolenz, Christian ^a   Trojan, Lutz ^a   Steidler, Annette ^a   Weiss, Christel ^a   Alken, Peter ^a   Grobholz, Rainer ^b   Michel, Maurice Stephan ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

D2 40; Immunohistochemistry; Lymph vessel density; Lymphangiogenesis; Muscle invasive bladder cancer; Podoplanin

Indexed keywords

CELL MARKER; MONOCLONAL ANTIBODY D2-40; MONOCLONAL ANTIBODY KI 67;

ADULT; AGED; ARTICLE; BLADDER CARCINOMA; CANCER GRADING; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYSTECTOMY; DISEASE ASSOCIATION; ENDOTHELIUM CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPHANGIOGENESIS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; TRANSITIONAL CELL CARCINOMA; TUMOR BLOOD FLOW;

AGED; ANTIBODIES, MONOCLONAL; CARCINOMA, TRANSITIONAL CELL; CELL COUNT; CYSTECTOMY; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 38749115074     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2007.08.030     Document Type: Article

References (22)

1. Alitalo K., Tammela T., and Petrova T.V. Lymphangiogenesis in development and human disease. Nature 438 (2005) 946-953
2. Nathanson S.D. Insights into the mechanisms of lymph node metastasis. Cancer 98 (2003) 413-423
3. Kaiserling E. Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology. Pathologe 25 (2004) 362-374
4. Schacht V., Dadras S.S., Johnson L.A., Jackson D.G., Hong Y.K., and Detmar M. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycopeotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 166 (2005) 913-921
5. Dadras S.S., Bertoncini P.T., Brown L.F., et al. Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 162 (2003) 1951-1960
6. Kyzas P.A., Geleff S., Batistatou A., Agnantis N.J., and Stefanou D. Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J Pathol 206 (2005) 170-177
7. Miyata Y., Kanda S., Ohba K., et al. Tumor lymphangiogenesis in transitional cell carcinoma of the upper urinary tract: association with clinicopathological features and prognosis. J Urol 176 (2006) 348-353
8. Padera T.P., Kadambi A., di Tomaso E., et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 296 (2002) 1883-1885
9. Williams C.S.M., Leek R.D., Robson A.M., et al. Absence of lymphangiogenesis and intratumoral lymph node vessels in human metastatic breast cancer. J Pathol 200 (2003) 195-206
10. Agarwal B., Saxena R., Morimiya A., Mehrotra S., and Badve S. Lymphangiogenesis does not occur in breast cancer. Am J Surg Pathol 29 (2005) 1449-1455
11. Van der Auwera I., Van den Eynden, Colpaert C.G., et al. Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study. Clin Cancer Res 11 (2005) 7637-7642
12. Renyi-Vamos F., Tovari J., Fillinger J., et al. Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer. Clin Cancer Res 11 (2005) 7344-7353
13. Zeng Y., Opeskin K., Horvath L.G., Sutherland R.L., and Williams E.D. Lymphatic vessel density and lymph node metastasis in prostate cancer. Prostate 65 (2005) 222-230
14. Liang P., Hong J.W., Ubukata H., et al. Increased density and diameter of lymphatic microvessels correlate with lymph node metastasis in early stage invasive colorectal carcinoma. Virchows Arch 448 (2006) 570-575
15. UICC. Urinary bladder. In: American Joint Committee on Cancer staging manual. 6th ed. New York: Springer; 2002. p. 310-5.
16. Mostofi FK, Sobin LH, Torloni H. Histological typing of urinary bladder tumors. In: World Health Organization: WHO histological classification of tumors, No 10. Geneva; 1973.
17. Trojan L., Michel M.S., Rensch F., Jackson D.G., Alken P., and Grobholz R. Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor (LYVE-1). J Urol 172 (2004) 103-107
18. Miyata Y., Kanda S., Ohba K., et al. Lymphangiogenesis and angiogenesis in bladder cancer: prognostic implications and regulation by vascular endothelial growth factors-A, -B, and -D. Clin Cancer Res 12 (2006) 800-806
19. Bono P., Wasenius V.M., Heikkilä P., Lundin J., Jackson D.G., and Joensuu H. High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer. Clin Cancer Res 10 (2004) 7144-7149
20. Franchi A., Gallo O., Massi D., Baroni G., and Santucci M. Tumor lymphangiogenesis in head and neck squamous cell carcinoma. A morphometric study with clinical correlations. Cancer 101 (2004) 973-978
21. Roma A.A., Magi-Galluzi C., Kral M.A., Jin T.T., Klein E.A., and Zhou M. Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma. Modern Pathology 19 (2006) 392-398
22. Herr H.W. Extent of surgery and pathology evaluation has an impact on bladder cancer outcomes after radical cystectomy. Urology 61 (2003) 105-108