The potential influence of CO2, as an agent for euthanasia, on the pharmacokinetics of basic compounds in rodents

Drug Metabolism and Disposition

Volumn 36, Issue 2, 2008, Pages 375-379

  Angus, Derek W ^a   Baker, James A ^a   Mason, Rona ^a   Martin, Iain J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; CENTRAL NERVOUS SYSTEM AGENTS; ISOFLURANE; ORG A; ORG B; RALOXIFENE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD GAS ANALYSIS; BLOOD PH; CENTRAL NERVOUS SYSTEM; CERVICAL SPINE DISLOCATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; EUTHANASIA; MALE; MOUSE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; RAT; RODENT; TISSUE DISTRIBUTION; ANIMAL; BLOOD; BRAIN; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOUSE STRAIN; WISTAR RAT;

MUS; RATTUS; RODENTIA;

ANIMALS; BLOOD GAS ANALYSIS; BRAIN; CARBON DIOXIDE; EUTHANASIA; MALE; MICE; MICE, INBRED ICR; MICE, INBRED STRAINS; RALOXIFENE; RATS; RATS, WISTAR;

EID: 38749113350     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.018879     Document Type: Article

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