Investigating the potential of statin medications as a nitric oxide (NO) release agent to decrease decompression sickness: A review article

Medical Hypotheses

Volumn 70, Issue 3, 2008, Pages 560-566

  Duplessis, Christopher A ^a   Fothergill, David ^a  

^a Navy Hospital Portsmouth   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERIVASTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NITRIC OXIDE; NITRIC OXIDE DONOR;

ARTICLE; CELL ADHESION; DECOMPRESSION SICKNESS; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; HUMAN; HYPOTENSION; MYALGIA; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR; UNSPECIFIED SIDE EFFECT; UPREGULATION;

DECOMPRESSION SICKNESS; ENDOTHELIUM, VASCULAR; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPIDS; MODELS, BIOLOGICAL; NITRIC OXIDE;

EID: 38749100990     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.04.050     Document Type: Article

References (37)

1. Andries L.J., Brutsaert D.L., and Sys S.U. Nonuniformity of endothelial constitutive nitric oxide synthase distribution in cardiac endothelium. Circ Res 82 2 (1998) 195-203
2. Balk E.M., Lau J., Goudas L.C., Jordan H.S., Kupelnick B., Kim L.U., et al. Effects of statins on nonlipid serum markers associated with cardiovascular disease: a systematic review. Ann Intern Med 139 8 (2003) 670-682
3. Behrendt D., and Ganz P. Endothelial function: from vascular biology to clinical applications. Am J Cardiol 90 10C (2002) 40-48
4. Bennett P., and Elliott D.H. In: Brubakk A., and Neuman T.S. (Eds). Physiology and medicine of diving. 5th ed. (2003), Elsevier Science/Saunders, London
5. Blatteau J.E., Gempp E., Galland F.M., Pontier J.M., Sainty J.M., and Robinet C. Aerobic exercise 2 h before a dive to 30 msw decreases bubble formation after decompression. Aviat Space Environ Med 76 7 (2005) 666-669
6. Bondi M., Cavaggioni A., Michieli P., Schiavon M., and Travain G. Delayed effect of nitric oxide synthase inhibition on the survival of rats after acute decompression. Undersea Hyperb Med 32 2 (2005) 121-128
7. Dujic Z., Duplancic D., Marinovic-Terzic I., Bakovic D., Ivancev V., Valic Z., et al. Aerobic exercise before diving reduces venous gas bubble formation in humans. J Physiol 555 3 (2004) 637-642
8. Dujic Z., Palada I., Valic Z., Duplancic D., Obad A., Wisloff U., et al. Exogenous nitric oxide and bubble formation in divers. Aviat Space Environ Med 77 9 (2006) 1432-1435
9. Duplessis C., Fothergill D., Schwaller D., Hughes L., and Gertner J. Prophylactic statins as a possible method to decrease bubble formation in diving. Aviat Space Environ Med 78 4 (2007) 430-434
10. Eftedal O., and Brubakk A.O. Agreement between trained and untrained observers in grading intravascular bubble signals in ultrasonic images. Undersea Hyperb Med 24 4 (1997) 293-299
11. Fenster B., Tsao P.S., and Rockson S.G. Stress endothelial dysfunction: clinical strategies for treating oxidant. Am Heart J 46 2 (2003) 218-226
12. Granger D.N., and Kubes P. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol 55 5 (1994) 662-675
13. Hills B. A hydrophobic oligolamellar lining to the vascular lumen in some organs. Undersea Biomed Res 19 2 (1992) 107-120
14. Jauchem J.R., Waligora J.M., Conkin J., Horrigan Jr. D.J., and Johnson Jr. P.C. Blood biochemical factors in humans resistant and susceptible to formation of venous gas emboli during decompression. Eur J Appl Physiol Occup Physiol 55 1 (1986) 68-73
15. Laufs U. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 273 37 (1998) 24266-24271
16. Laufs U. Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transciption. Circulation 102 25 (2000) 3104-3110
17. Laufs U., Wassmann S., Hilgers S., Ribaudo N., Bohm M., and Nickenig G. Rapid effects on vascular function after initiation and withdrawal of atorvastatin in healthy, normocholesterolemic men. Am J Cardiol 88 11 (2001)
18. Loset A., Mollerlokken A., Berge V., Wisloff U., and Brubakk A.O. Post-dive bubble formation in rats: effects of exercise 24 h ahead repeated 30 min before the dive. Aviat Space Environ Med 77 9 (2006) 905-908
19. Luscher T.F., Djederich D., Siebenmann R., Lehmann K., Stulz P., von Segesser L., et al. Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N Engl J Med 319 8 (1988) 462-467
20. Martin J.D., and Thom S.R. Vascular leukocyte sequestration in decompression sickness and prophylactic hyperbaric oxygen therapy in rats. Aviat Space Environ Med 73 6 (2002) 565-569
21. Mason R., Walter M.F., and Jacob R.F. Effects of HMG-CoA reductase inhibitors on endothelial function: role of microdomains and oxidative stress. Circulation 109 21 (2004) 34-41
22. Mollerlokken A., Berge V., Wisloff U., and Brubakk A.O. Post-dive bubble formation in rats: effects of exercise 24 h ahead repeated 30 min before the dive. Aviat Space Environ Med 77 9 (2006) 905-908
23. Mollerlokken A., Berge V.J., Jorgensen A., Wisloff U., and Brubakk A.O. Effect of a short-acting NO donor on bubble formation from a saturation dive in pigs. J Appl Physiol 101 6 (2006) 1541-1545
24. Nossum V., Hjelde A., and Brubakk A.O. Small amounts of venous gas embolism cause delayed impairment of endothelial function and increase polymorphonuclear neutrophil infiltration. Eur J Appl Physiol 86 3 (2002) 209-214
25. Pollock J.S., Nakane M., Buttery L.D., Martinez A., Springall D., Polak J.M., et al. Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. Am J Physiol 265 5 Pt 1 (1993) C1379-C1387
26. Salinas D., Sparkman L., Berhane K., and Boggaram V. Nitric oxide inhibits surfactant protein B gene expression in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 285 5 (2003) 1153-1165
27. Seidel C.L., and LaRochelle J. Venous and arterial endothelia: different dilator abilities in dog vessels. Circ Res 60 4 (1987) 626-630
28. Sowers J. Effects of statins on the vasculature: implications for aggressive lipid management in the cardiovascular metabolic syndrome. Am J Cardiol 91 4 (2003) 14-22
29. Suzuki A., Armstead S.C., and Eckmann D.M. Surfactant reduction in embolism bubble adhesion and endothelial damage. Anesthesiology 101 1 (2004) 97-103
30. Tripodi D., Dupas B., Potiron M., Louvet S., and Geraut C. Brain magnetic resonance imaging, aerobic power, and metabolic parameters among 30 asymptomatic scuba divers. Int J Sports Med 25 8 (2004) 575-581
31. Tsunekawa T. Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days. Circulation 104 4 (2001) 376-379
32. Wagner A. Improvement of nitric oxide dependent vasodilation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol 20 1 (2000) 61-69
33. Wassman S. HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species. Hypertension 37 6 (2001) 1450-1457
34. Wisloff U., and Brubakk A.O. Aerobic endurance training reduces bubble formation and increases survival in rats exposed to hyperbaric pressure. J Physiol 537 2 (2001) 607-611
35. Wisloff U., Richardson R.S., and Brubakk A.O. NOS inhibition increases bubble formation and reduces survival in sedentary but not exercised rats. J Physiol 546 2 (2003) 577-582
36. Wisloff U., Richardson R.S., and Brubakk A.O. Exercise and nitric oxide prevent bubble formation:a novel approach to the prevention of decompression sickness?. J Physiol 555 3 (2004) 825-829
37. Gauthier T.W., Davenpeck K.L., and Lefer A.M. Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion. Am J Physiol 267 4 (1994) 562-568