Exercise and nitric oxide prevent bubble formation: A novel approach to the prevention of decompression sickness?

Journal of Physiology

Volumn 555, Issue 3, 2004, Pages 825-829

  Wisløff, Ulrik ^a,b   Richardson, Russell S ^a,c   Brubakk, Alf O ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOSORBIDE MONONITRATE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; DEATH; DECOMPRESSION SICKNESS; DRUG MECHANISM; EXERCISE; FEMALE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SITTING; STATISTICAL SIGNIFICANCE; SURVIVAL; VASCULAR ENDOTHELIUM; ADULT; BLOOD GAS PARAMETERS; BUBBLE FORMATION; LUNG GAS EXCHANGE; VENOUS OXYGEN TENSION;

ANIMALS; DECOMPRESSION SICKNESS; DIVING; FEMALE; ISOSORBIDE DINITRATE; MOTOR ACTIVITY; NITRIC OXIDE; NITRIC OXIDE DONORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 1642565831     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.055467     Document Type: Article

References (17)

1. Bath PM (1993). The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro. Eur J Clin Pharm 45, 53-58.
2. Dervay JP, Powell MR, Butler B & Fife CE (2002). The effect of exercise and rest duration on the generation of venous gas bubbles at altitude. Aviat Space Environ Med 73, 22-27.
3. Eftedal O & Brubakk A (1997). Agreement between trained and untrained observers in grading intravascular bubble signals in ultrasonic images. Undersea Hyperbar Med 24, 293-299.
4. Francis T & Gorman D (1993). Pathogenesis of the decompression disorders. In The Physiology and Medicine of Diving, ed. Elliot DH & Bennett PB, pp. 454-480.W.B. Saunders, London.
5. Gillen CM, Lee R, Mack GW, Tomaselli CM, Nishiyasu T & Nadel ER (1991). Plasma volume expansion in humans after a single intense exercise protocol. J Appl Physiol 71, 1914-1920.
6. Harvey EN (1951). Physical factors in bubble formation. In Decompression Sickness, ed. Fulton JF, pp. 90-114. W.B. Saunders, Philadelphia and London.
7. Harvey EN, McElroy WD, Whiteley AH, Warren GH & Pease DC (1944). Bubble formation in animals. III. An analysis of gas tension and hydrostatic pressure in cats. J Cell Comp Physiol 24, 117-132.
8. McDonough PM & Hemmingsen EA (1985a). A direct test for the survival of gaseous nuclei in vivo. Aviat Space Environ Med 56, 54-56.
9. McDonough PM & Hemmingsen EA (1985b). Swimming movements initiate bubble formation in fish decompressed from elevated gas pressures. Comp Biochem Physiol A 81, 209-212.
10. Merton DA, Fife WP & Gross DR (19C3). An evaluation of plasma volume expanders in the treatment of decompression sickness. Aviat Space Environ Med 54, 218-222.
11. Richardson RS, Verstraete D, Johnson SC, Luetkemeier MJ & Stray-Gundersen J (1996). Evidence of a secondary hypervolemia in trained man following acute high intensity exercise. Int J Sports Med 17, 243-247.
12. Roberts CK, Barnard RJ, Jasman A & Balon TW (1999). Acute exercise increases nitric oxide synthase activity in skeletal muscle. Am J Physiol 277, E390-E394.
13. Vann RD (1989). Exercise and circulation in the formation and growth of bubbles. In Supersaturation and Bubble Formation in Fluid and Organisms, ed. Brubakk AO, Hemmingsen BB & Saunders G, pp. 235-258. Tapir, Trondheim.
14. Vann RD, Grimstad J & Nielsen CH (1980). Evidence for gas nuclei in decompressed rats. Undersea Biomed Res 7, 107-112.
15. Wisløff U & Brubakk A (2001). Aerobic endurance training reduces bubble formation and increases survival in rats exposed to hyperbaric pressure. J Physiol 537, 607-611.
16. Wisløff U, Richardson RS & Brubakk AO (2003). NOS inhibition increases bubble formation and reduces survival in sedentary but not exercised rats. J Physiol 546, 577-582.
17. Yount D & Strauss R (1982). On the evolution, generation and regeneration of gas cavitation nuclei. J Acoust Soc AM 65, 1431-1439.