Sealing the skin barrier around transcutaneous implants: In vitro study of keratinocyte proliferation and adhesion in response to surface modifications of titanium alloy

Journal of Bone and Joint Surgery - Series B

Volumn 90, Issue 1, 2008, Pages 114-121

  Pendegrass, C J ^a   Gordon, D ^a   Middleton, C A ^a   Man Sun, S Ng ^a   Blunn, G W ^a  

^a ROYAL NATIONAL ORTHOPAEDIC HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PLECTIN; TITANIUM;

AMPUTATION STUMP; ARTICLE; CELL PROLIFERATION; HUMAN; HUMAN CELL; IMMUNOLOCALIZATION; KERATINOCYTE; LIMB AMPUTATION; PRIORITY JOURNAL; PROSTHESIS; SCANNING ELECTRON MICROSCOPY; SKIN FUNCTION; TRANSMISSION ELECTRON MICROSCOPY;

ALLOYS; AMPUTATION STUMPS; ARTIFICIAL LIMBS; BIOCOMPATIBLE MATERIALS; CELL ADHESION; HUMANS; KERATINOCYTES; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; PROSTHESIS DESIGN; SURFACE PROPERTIES; TITANIUM;

EID: 38749092152     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.90B1.19580     Document Type: Article

References (32)

1. Von Recum AF. Applications and failure modes of percutaneous devices: a review. J Biomed Mater Res 1984;18:323-36.
2. Moens P, Lylle J, Lammens J, Fabry G. Correction of severe deformities of the foot using Ilizarov's equipment. Rev Chir Orthop Reparatrice Appar Mot 1994;80:118-22 (in French).
3. Ring D, Jupiter JB, Labropovlos PK, et al. Treatment of deformity of the lower limb in adults who have osteogenesis imperfecta. J Bone Joint Surg [Am] 1996;78-A:220-5.
4. Theis JC, Simpson H, Kenwright J. Correction of complex lower limb deformities by the Ilizarov technique: an audit of complications. J Orthop Surg (Hong Kong) 2000;8:67-71.
5. Dudek NL, Marks MB, Marshall SC. Skin problems in an amputee clinic. Am J Phys Med Rehabil 2006;85:424-9.
6. Levy SW. Amputees: skin problems and prostheses. Curtis 1995;55:297-301.
7. Kohler P, Lindh L, Bjorklind A. Bacteria on stumps of amputees and the effect of antiseptics. Prosthet Orthot Int 1989;13:149-51.
8. Branemark PI, Breine U, Adell R, et al. Intra-osseous anchorage of dental prostheses. Scand J Plast Recon Surg 1969;3:81-100.
9. Branemark PI. Tooth replacement by oral endoprostheses: clinical aspects. Int J Oral Implantol 1988;5:27-9.
10. Branemark R, Branemark PI, Rydevik B, Myers RR. Osseointegration in skeletal reconstruction and rehabilitation: a review. J Rehabil Res Dev 2001;38:175-81.
11. Sullivan J, Uden M, Robinson KP, Sooriakumaran S. Rehabilitation of the trans-femoral amputee with an osseointegrated prosthesis: the United Kingdom experience. Prosthet Orthot Int 2003;27:114-20.
12. Pendegrass CJ, Goodship AE, Price JS, Blunn GW. Nature's answer to breaching the skin barrier: an innovative development for amputees. J Anatomy 2006;209:59-67.
13. Pendegrass CJ, Goodship AE, Blunn GW. Development of a soft tissue seal around bone-anchored transcutaneous amputation prostheses. Biomaterials 2006;27:4183-91.
14. Meredith DO, Eschbach L, Wood MA, et al. Human fibroblast reactions to standard and electropolished titanium and Ti-6A1-7Nb, and electropolished stainless steel. J Biomed Mater Res (Part A) 2005;75:541-55.
15. Eisenbarth E, Meyle J, Nachtigal W, Breme J. Influence of the surface structure of titanium mats on the adhesion of fibroblasts. Biomaterials 1996;17:1399-403.
16. Meredith DO, Eschbach L, Riehle MO, Curtis AS, Richards RG. Microtopography of metal surfaces influence fibroblast growth by modifying cell shape, cytoskeleton and adhesion. J Orthop Res 2007: in press.
17. Middleton CA, Pendegrass CJ, Gordon D, Jacob J, Blunn GW. Fibronectin silanized titanium alloy: a bioinductive and durable coating to enhance fibroblast attachment in vitro. J Biomed Mater Res (Part A) 2007;83:1032-8.
18. Jones JCR, Hopkinson SB, Goldfinger LE. Structure and assembly of hemidesmosomes. Bioassays 1998;20:488-94.
19. Borradori L, Sonnenberg A. Stucture and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol 1999;112:411-18.
20. Nievers MG, Kuikman I, Geerts D, Leigh IM, Sonnenberg A. Formation of hemidesmosome-like structures in the absence of ligand binding by the alpha 6 beta 4 integrin requires binding of HD1/plectin to the cytoplasmic domain of the beta 4 integrin subunit. J Cell Sci 2000;113:963-73.
21. Katz BZ, Zamir E, Bershadsky A, et al. Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions. Mol Biol Cell 2000;11:1047-60.
22. Bosman FT, Stamenkovic I. Functional structure and composition of the extracellular matrix. J Pathology 2003;200:423-8.
23. Folkman J, Moscona A. Role of cell shape in growth control. Nature 1978;273:345-9.
24. Jansen JA, De Wijn JR, Wolters-Lutgerhorst JM, Van Mullen PJ. Ultrastructural study of epithelial cell attachment to implant materials. J Dent Res 1985;64:891-6.
25. Kiyokawa E, Hashimoto Y, Kobayashi S, et al. Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev 1998;12:3331-6.
26. Barry ST, Flinn HM, Humphries MJ, Critchley DR, Ridley AJ. Requirement for Rho in integrin signaling. Cell Ahes Commun 1997;4:387-98.
27. Kurpakus MA, Quaranta V, Jones JCR. Surface relocation of alpha 6 beta 4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing. J Cell Biol 1991;115:1737-50.
28. Giancotti FG. Signal transduction by the alpha 6 beta 4 integrin: charting the path between laminin binding and nuclear events. J Cell Sci 1996;109:1165-72.
29. Hormia M, Owaribe K, Virtanen I. The dento-epithelial junction: adhesion by type-1 hemidesmosomes in the absence of a true basal lamina. J Peridontol 2001;72:788-97.
30. Ikeda H, Yamaza T, Yoshinari M, et al. Ultrastructural and immunoelectron microscopis studies of the peri-implant epithelium-implant (Ti-6AL-4V) interface of rat maxilla. J Peridontol 2000;71:961-73.
31. Scheideler L, Ruopp F, Wendel HP, Sathe S, Geis-Gerstorfer J. Photocoupling of fibronectin to titanium surfaces influences keratinocyte adhesion, pellicle formation and thrombogenicity. Dental Materials 2007;23:469-78.
32. Bush KA, Downing BR, Walsh SE, Pins GD. Conjugation of extracellular matrix proteins to basal lamina analogs enhances keratinocyte attachment. J Biomed Mater Res (Part A) 2007;80:444-52.