Treatment with haloperidol and diazepam alters GABAA receptor density in the rat brain

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 2, 2008, Pages 560-567

  McLeod, Mark C ^a,b   Sundram, Suresh ^a,c   Dean, Brian ^a,b,c,d  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MONASH UNIVERSITY   (Australia)

Author keywords

Benzodiazepine; Diazepam; GABAA receptor; Haloperidol

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; FLUMAZENIL; HALOPERIDOL; ZOLPIDEM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; FRONTAL CORTEX; HYPOTHALAMUS; LIGAND BINDING; NONHUMAN; PARIETAL LOBE; RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; AUTORADIOGRAPHY; BENZODIAZEPINES; BINDING SITES; BRAIN; DIAZEPAM; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; FLUMAZENIL; HALOPERIDOL; HIPPOCAMPUS; HUMANS; INJECTIONS, INTRAPERITONEAL; MUSCIMOL; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SCHIZOPHRENIA; THALAMUS; TISSUE DISTRIBUTION;

EID: 38749087642     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2007.10.017     Document Type: Article

References (55)

1. Alexander J., Tharyan P., Adams C., John T., Mol C., and Philip J. Rapid tranquillisation of violent or agitated patients in a psychiatric emergency setting. Pragmatic randomised trial of intramuscular lorazepam v. haloperidol plus promethazine. Br J Psychiatry 185 (2004) 63-69
2. Barnard E.A., Darlison M.G., Fujita N., Glencorse T.A., Levitan E.S., Reale V., et al. Molecular biology of the GABAA receptor. Adv Exp Med Biol 236 (1988) 31-45
3. Benes F.M., Vincent S.L., Alsterberg G., Bird E.D., and SanGiovanni J.P. Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics. J Neurosci 12 (1992) 924-929
4. Benes F.M., Khan Y., Vincent S.L., and Wickramasinghe R. Differences in the subregional and cellular distribution of GABAA receptor binding in the hippocampal formation of schizophrenic brain. Synapse 22 (1996) 338-349
5. Benes F.M., Vincent S.L., Marie A., and Khan Y. Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjects. Neuroscience 75 (1996) 1021-1031
6. Benes F.M., Wickramasinghe R., Vincent S.L., Khan Y., and Todtenkopf M. Uncoupling of GABA(A) and benzodiazepine receptor binding activity in the hippocampal formation of schizophrenic brain. Brain Res 755 (1997) 121-129
7. Brown M.J., Wood M.D., Coldwell M.C., and Bristow D.R. Gamma-aminobutyric acidA receptor function is desensitised in rat cultured cerebellar granule cells following chronic flunitrazepam treatment. J Neurochem 71 (1998) 1232-1240
8. Buckland P.R., O'Donovan M.C., and McGuffin P. Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology (Berl) 106 (1992) 479-483
9. Canonaco M., O'Connor L.H., Pfaff D.W., and McEwen B.S. GABA[A] receptor level changes in female hamster forebrain following in vivo estrogen progesterone and benzodiazepine treatment: a quantitative autoradiography analysis. Exp Brain Res 75 (1989) 644-652
10. Dean B., Hussain T., Hayes W., Scarr E., Kitsoulis S., Hill C., et al. Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex. J Neurochem 72 (1999) 1593-1599
11. Dean B., Hussain T., Scarr E., Pavey G., and Copolov D.L. Extended treatment with typical and atypical antipsychotic drugs differential effects on the densities of dopamine D2-like and GABAA receptors in rat striatum. Life Sci 69 (2001) 1257-1268
12. DeFeudis F.V., Ossola L., and Mandel P. More muscimol binding sites than GABA binding sites in a particulate fraction of rat brain. Biochem Pharmacol 28 (1979) 2687-2689
13. Elliot E.E., and White J.M. The acute effects of zolpidem compared to diazepam and lorazepam using radiotelemetry. Neuropharmacology 40 (2001) 717-721
14. Fahey J.M., Pritchard G.A., Grassi J.M., Pratt J.S., Shader R.I., and Greenblatt D.J. Pharmacodynamic and receptor binding changes during chronic lorazepam administration. Pharmacol Biochem Behav 69 (2001) 1-8
15. Farnbach-Pralong D., Bradbury R., Copolov D., and Dean B. Clozapine and olanzapine treatment decreases rat cortical and limbic GABA(A) receptors. Eur J Pharmacol 349 (1998) R7-R8
16. Frey J.M., Ticku M.K., and Huffman R.D. GABAergic supersensitivity within the pars reticulata of the rat substantia nigra following chronic haloperidol administration. Brain Res 425 (1987) 73-84
17. Frey J.M., Ticku M.K., Bell R.D., and Huffman R.D. Chronic haloperidol administration increases GABA binding and enhances neuronal responsiveness to iontophoresed GABA in rat globus pallidus. Brain Res 491 (1989) 57-67
18. Gale K. Chronic blockade of dopamine receptors by antischizophrenic drugs enhances GABA binding in substantia nigra. Nature 283 (1980) 569-570
19. Gallager D.W., Malcolm A.B., Anderson S.A., and Gonsalves S.F. Continuous release of diazepam: electrophysiological, biochemical and behavioral consequences. Brain Res 342 (1985) 26-36
20. Greenblatt D.J., Miller L.G., and Shader R.I. Benzodiazepine discontinuation syndromes. Benzodiazepine discontinuation syndromes. J Psychiatr Res 24 Suppl 2 (1990) 73-79
21. 3H]muscimol binding sites increased in autopsied brains of chronic schizophrenics. Life Sci 40 (1987) 259-266
22. 3H]SR 95531, a GABAA antagonist, to rat brain membranes. J Neurochem 48 (1987) 1677-1686
23. Herrera-Marschitz M., and Ungerstedt U. The dopamine-gamma aminobutyric acid interaction in the striatum of the rat is differently regulated by dopamine D-1 and D-2 types of receptor: evidence obtained with rotational behavioural experiments. Acta Physiol Scand 129 (1987) 371-380
24. Huffman R.D., and Ticku M.K. The effects of chronic haloperidol administration on GABA receptor binding. Pharmacol Biochem Behav 19 (1983) 199-204
25. Hutchinson M.A., Smith P.F., and Darlington C.L. The behavioural and neuronal effects of the chronic administration of benzodiazepine anxiolytic and hypnotic drugs. Prog Neurobiol 49 (1996) 73-97
26. Impagnatiello F., Pesold C., Longone P., Caruncho H., Fritschy J.M., Costa E., et al. Modifications of gamma-aminobutyric acidA receptor subunit expression in rat neocortex during tolerance to diazepam. Mol Pharmacol 49 (1996) 822-831
27. Kiuchi Y., Kobayashi T., Takeuchi J., Shimizu H., Ogata H., and Toru M. Benzodiazepine receptors increase in post-mortem brain of chronic schizophrenics. Eur Arch Psychiatry Neurol Sci 239 (1989) 71-78
28. Lewis D.A., Volk D.W., and Hashimoto T. Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction. Psychopharmacology (Berl) 174 (2004) 143-150
29. Liberatore G.T., Wong J.Y., Krenus D., Jeffreys B.J., Porritt M.J., and Howells D.W. Tissue fixation prevents contamination of tritium-sensitive storage phosphor imaging plates. Biotechniques 26 (1999) 432-434
30. 3H]flumazenil and zolpidem. Brain Res Mol Brain Res 104 (2002) 203-209
31. A-receptors and anxiety (1995), Raven Press, New York 41-56
32. Mohler H., Knoflach F., Paysan J., Motejlek K., Benke D., Luscher B., et al. Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation. Neurochem Res 20 (1995) 631-636
33. Nabeshima T., Yamada K., Hayashi T., Hasegawa T., Ishihara S., Kameyama T., et al. Changes in muscarinic cholinergic, PCP, GABAA, D1, and 5-HT2A receptor binding, but not in benzodiazepine receptor binding in the brains of aged rats. Life Sci. 55 (1994) 1585-1593
34. 3H]flunitrazepam binding sites. J Neurochem 49 (1987) 890-899
35. Olsen R.W., McCabe R.T., and Wamsley J.K. GABAA receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J Chem Neuroanat 3 (1990) 59-76
36. Owen F., Cross A.J., Crow T.J., Lofthouse R., and Poulter M. Neurotransmitter receptors in brain in schizophrenia. Acta Psychiatr Scand Suppl 291 (1981) 20-28
37. Palacios J.M., Wamsley J.K., and Kuhar M.J. High affinity GABA receptors-autoradiographic localization. Brain Res 222 (1981) 285-307
38. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates (1986), Academic Press, New York
39. Pazo J.H., Levi de S.M., Jerusalinsky D., Novas M.L., Raskovsky S., Tumilasci O.R., et al. Selective increase of alpha 1-adrenoceptors and muscarinic cholinergic receptors in rat cerebral cortex after chronic haloperidol. Brain Res 414 (1987) 405-408
40. Pritchett D.B., Luddens H., and Seeburg P.H. Type I and type II GABAA-benzodiazepine receptors produced in transfected cells. Science 245 (1989) 1389-1392
41. Ramsey-Williams V.A., Wu Y., and Rosenberg H.C. Comparison of anticonvulsant tolerance, crosstolerance, and benzodiazepine receptor binding following chronic treatment with diazepam or midazolam. Pharmacol Biochem Behav 48 (1994) 765-772
42. Rodbard D. Mathematics and statistics of ligand assays: an illustrated guide. In: Langan J., and Clapp J.J. (Eds). Ligand assay: analysis of international developments on isotopic and nonisotopic immunoassay (1981), Masson Punlishing USA, Inc, New York 45-99
43. Rothe T., and Langer M. Prenatal diazepam exposure affects beta-adrenergic receptors in brain regions of adult rat offspring. J Neurochem. 51 (1988) 1361-1366
44. See R.E., Aravagiri M., and Ellison G.D. Chronic neuroleptic treatment in rats produces persisting changes in GABAA and dopamine D-2, but not dopamine D-1 receptors. Life Sci 44 (1989) 229-236
45. See R.E., Toga A.W., and Ellison G. Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats. J Neural Transm Gen Sect 82 (1990) 93-109
46. Shirakawa O., and Tamminga C.A. Basal ganglia GABAA and dopamine D1 binding site correlates of haloperidol-induced oral dyskinesias in rat. Exp Neurol 127 (1994) 62-69
47. 3H]aminobutyric acid release?. J Neurochem 49 (1987) 1042-1049
48. Toki S., Saito T., Hatta S., and Takahata N. Diazepam physical dependence and withdrawal in rats is associated with alteration in GABAA receptor function. Life Sci 59 (1996) 1631-1641
49. Toki S., Saito T., Nabeshima A., Hatta S., Watanabe M., and Takahata N. Changes in GABAA receptor function and cross-tolerance to ethanol in diazepam-dependent rats. Alcohol Clin Exp Res 20 (1996) 40A-44A
50. Wan D.C., Dean B., Pavey G., and Copolov D.L. Treatment with haloperidol or clozapine causes changes in dopamine receptors but not adenylate cyclase or protein kinase C in the rat forebrain. Life Sci 59 (1996) 2001-2008
51. 3H]muscimol binding to mouse brain membranes. Biochem Pharmacol 28 (1979) 1123-1128
52. Wu Y., Rosenberg H.C., Chiu T.H., and Zhao T.J. Subunit-and brain region-specific reduction of GABAA receptor subunit mRNAs during chronic treatment of rats with diazepam. J Mol Neurosci 5 (1994) 105-120
53. Young III W.S., and Kuhar M.J. Radiohistochemical localization of benzodiazepine receptors in rat brain. J Pharmacol Exp Ther 212 (1980) 337-346
54. Zharkovskii A.M., and Zharkovskaia T.A. Changes in the number of benzodiazepine receptors in different parts of the brain of rats after neuroleptic withdrawal. Biull Eksp Biol Med 98 (1984) 457-459
55. Zink M., Schmitt A., May B., Muller B., Demirakca T., Braus D.F., et al. Differential effects of long-term treatment with clozapine or haloperidol on GABAA receptor binding and GAD67 expression. Schizophr Res 66 (2004) 151-157