-
1
-
-
26044448065
-
-
For a recent review, see
-
For a recent review, see: Vieira, L. M. M., Kijjoa, A. Curr. Med. Chem. 2005, 12, 2413.
-
(2005)
Curr. Med. Chem
, vol.12
, pp. 2413
-
-
Vieira, L.M.M.1
Kijjoa, A.2
-
2
-
-
26044467360
-
-
For a recent review, see
-
For a recent review, see: Pinto, M. M. M., Sousa, M. E., Nascimento, M. S. J. Curr. Med. Chem. 2005, 12, 2517.
-
(2005)
Curr. Med. Chem
, vol.12
, pp. 2517
-
-
Pinto, M.M.M.1
Sousa, M.E.2
Nascimento, M.S.J.3
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3
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26044481179
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For a recent review, see
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For a recent review, see: Sousa, M. E.; Pinto, M. M. M. Curr. Med. Chem. 2005, 12, 2447.
-
(2005)
Curr. Med. Chem
, vol.12
, pp. 2447
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Sousa, M.E.1
Pinto, M.M.M.2
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6
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33846246047
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This group has also recently reported xanthone synthesis via an aryl to imidazoyl migration process involving C-H activation
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(a) Zhao, J.; Larock, R. C. Org. Lett. 2007, 72, 583. This group has also recently reported xanthone synthesis via an aryl to imidazoyl migration process involving C-H activation.
-
(2007)
Org. Lett
, vol.72
, pp. 583
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Zhao, J.1
Larock, R.C.2
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7
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34247550695
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See b
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See (b) Zhao, J.; Yue, D.; Campo, M. A.; Larock, R. C. J. Am. Chem. Soc. 2007, 129, 5288.
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 5288
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Zhao, J.1
Yue, D.2
Campo, M.A.3
Larock, R.C.4
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8
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33748631331
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(a) Ghosh, C. K.; Bhattacharyya, S.; Patra, A. J. Chem. Soc., Perkin Trans. 1 1997, 15, 2167.
-
(1997)
J. Chem. Soc., Perkin Trans. 1
, vol.15
, pp. 2167
-
-
Ghosh, C.K.1
Bhattacharyya, S.2
Patra, A.3
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9
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0034700383
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(b) Kelkar, A. S.; Letcher, R. M.; Cheung, K. K.; Chiu, K. F.; Brown, G. D. J. Chem. Soc., Perkin Trans. 1 2000, 3732.
-
(2000)
J. Chem. Soc., Perkin Trans. 1
, pp. 3732
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Kelkar, A.S.1
Letcher, R.M.2
Cheung, K.K.3
Chiu, K.F.4
Brown, G.D.5
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10
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0032894356
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IEDDA reactions of isomeric coumarin-fused electron deficient dienes with enamines 2 afforded benzocoumarins via a domino IEDDA / elimination / dehydrogenation sequence. See: Bodwell, G. J.; Pi, Z.; Pottie, I. R. Synlett 1999, 477.
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IEDDA reactions of isomeric coumarin-fused electron deficient dienes with enamines 2 afforded benzocoumarins via a domino IEDDA / elimination / dehydrogenation sequence. See: Bodwell, G. J.; Pi, Z.; Pottie, I. R. Synlett 1999, 477.
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11
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38649143849
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Mechanistically, this is an elimination reaction. Like all elimination reactions, it is an intramolecular reaction, but it differs from most others in that the reverse reaction is an intramolecular addition
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Mechanistically, this is an elimination reaction. Like all elimination reactions, it is an intramolecular reaction, but it differs from most others in that the reverse reaction is an intramolecular addition.
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13
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0017803495
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Bellus, D.; Fischer, H.; Greuter, H.; Martin, P. Helv. Chim. Acta 1978, 61, 1784.
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(1978)
Helv. Chim. Acta
, vol.61
, pp. 1784
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Bellus, D.1
Fischer, H.2
Greuter, H.3
Martin, P.4
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15
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0008999998
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For the preparation of the ylide leading to 1d, see: Bell, T. W; Sondheimer, F. J. Org. Chem. 1981, 46, 217.
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For the preparation of the ylide leading to 1d, see: Bell, T. W; Sondheimer, F. J. Org. Chem. 1981, 46, 217.
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17
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38749146789
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Jpn. Kokai Tokyo Koho, JP50052067
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(a) Nohara, A.; Umetani, T.; Sanno, Y. Jpn. Kokai Tokyo Koho 1975, JP50052067.
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(1975)
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Nohara, A.1
Umetani, T.2
Sanno, Y.3
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18
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10844286205
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(b) Silva, V. L. M. Silva, A. M. S. Pinto, D. C. G. A. Cavaleiro, J. A. S. Patonay, T. Synlett 2004, 2717.
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(2004)
Synlett
, pp. 2717
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Silva, V.L.M.1
Silva, A.M.S.2
Pinto, D.C.G.A.3
Cavaleiro, J.A.S.4
Patonay, T.5
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19
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0022442643
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For 11, see: Watanabe, M.; Hisamatsu, S.; Hotokezaka, H.; Furukawa, S. Chem. Pharm. Bull. 1986, 34, 2810.
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For 11, see: Watanabe, M.; Hisamatsu, S.; Hotokezaka, H.; Furukawa, S. Chem. Pharm. Bull. 1986, 34, 2810.
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20
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0001725964
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For the phosphonate leading to 1c, see: Mathey, F.; Savignac, P. Tetrahedron 1978, 34, 649.
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For the phosphonate leading to 1c, see: Mathey, F.; Savignac, P. Tetrahedron 1978, 34, 649.
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21
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85027984620
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For the phosphonate leading to 1e, see: Enders, D.; von Berg, S.; Jandeleit, B. Org. Synth. 2002, 78, 169.
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For the phosphonate leading to 1e, see: Enders, D.; von Berg, S.; Jandeleit, B. Org. Synth. 2002, 78, 169.
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22
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38749084108
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A stepwise reaction (Michael/Mannich) cannot be ruled out at this time, but we currently favor the asynchronous IEDDA pathway. More detailed commentary on this subject will be forthcoming.
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A stepwise reaction (Michael/Mannich) cannot be ruled out at this time, but we currently favor the asynchronous IEDDA pathway. More detailed commentary on this subject will be forthcoming.
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23
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38749098050
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For example, in the case of 17b, this H atom is part of a vinylogous malonate, i.e., glutaconate, system.
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For example, in the case of 17b, this H atom is part of a vinylogous malonate, i.e., glutaconate, system.
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24
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38749118554
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On the surface, this elimination doesn't appear to be disfavored in any way. In an AM1-calculated (ref 21) structure of 18f, a H-C-C-O dihedral angle of 164° at the site of elimination is predicted.
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On the surface, this elimination doesn't appear to be disfavored in any way. In an AM1-calculated (ref 21) structure of 18f, a H-C-C-O dihedral angle of 164° at the site of elimination is predicted.
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25
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38749153148
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The question arises of whether the reactions of dienes 1 with enamine 8 involve a similar rearrangement. Based on the evidence that is currently available, this possibility cannot be discounted.
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The question arises of whether the reactions of dienes 1 with enamine 8 involve a similar rearrangement. Based on the evidence that is currently available, this possibility cannot be discounted.
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27
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14144251531
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(a) Zborowski, K.; Ryszard, G.; Proniewicz, L. M. J. Phys. Org. Chem. 2005, 18, 250.
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(2005)
J. Phys. Org. Chem
, vol.18
, pp. 250
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Zborowski, K.1
Ryszard, G.2
Proniewicz, L.M.3
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28
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0347117314
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(b) Lumbroso, H.; Cure, J.; Evers, M.; Z. Naturforsch. A 1986, 41, 1250.
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(1986)
Z. Naturforsch. A
, vol.41
, pp. 1250
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Lumbroso, H.1
Cure, J.2
Evers, M.3
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Chem3D, Version 5.0
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Chem3D, Version 5.0.
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(a) Heinz, B.; Schmidt, B.; Root, C.; Satzger, H.; Milota, F.; Fierz, B.; Kiefhaber, T.; Zinth, W.; Gilch, P. Phys. Chem. Chem. Phys. 2006, 8, 3432.
-
(2006)
Phys. Chem. Chem. Phys
, vol.8
, pp. 3432
-
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Heinz, B.1
Schmidt, B.2
Root, C.3
Satzger, H.4
Milota, F.5
Fierz, B.6
Kiefhaber, T.7
Zinth, W.8
Gilch, P.9
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The intensity changes indicate that there are other (yet to be identified) nonradiative pathways that lower fm
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m.
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o) energies, respectively.
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o) energies, respectively.
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