Hypermethylation of promoter region of RAS association domain family gene1A in esophageal squamous cell carcinoma and significance thereof

National Medical Journal of China

Volumn 87, Issue 41, 2007, Pages 2932-2934

  Cong, De Gang ^a   Wang, Sheng Fa ^b  

^a HANGZHOU NORMAL UNIVERSITY   (China)

^b NONE

Author keywords

Esophageal neoplasms; Genes, suppressor, tumor; Methylation

Indexed keywords

RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER TISSUE; CARCINOGENESIS; CONTROLLED STUDY; DISEASE ASSOCIATION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS RESECTION; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN HYPERMETHYLATION; PROTEIN METHYLATION; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CPG ISLANDS; DNA METHYLATION; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROSPECTIVE STUDIES; TUMOR SUPPRESSOR PROTEINS;

EID: 38749085244     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Dammann R, Li C, Yoon JH, et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet, 2000, 25:315-319.
2. Seung MD, Dong S, Nicole E, et al. Epigenetic inactivation of RASSF1 A in head and neck cancer. Clin Cancer Res, 2003, 9: 3635-3640.
3. Chinese source.
4. Chinese source.
5. Burbee DG, Forgacs E, Minna JD, et al. Epigenetic inactivation of RASSF1 A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst, 2001, 93:691-699.
6. Dreijerink K, Braga E, Kuzmin I, et al. The candidate tumor suppressor gene, RASSF1 A, from human chromosome 3p21. 3 is involved in kidney tumorigenesis. J Proc Natl Acad Sci USA, 2001, 98:7504-7509.
7. Kuroki T, Trapasso F, Yendamuri S, et al. Promoter hypermethylation of RASSF1 A in esophageal squamous cell carcinoma. J Clin Cancer Res, 2003, 9:1441-1445.
8. Wong ML, Tao Q, Fu L, et al. Aberrant promoter hypermethylation and silencing of the critical 3p21 tumour suppressor gene, RASSF1 A,in Chinese oesophageal squamous cell carcinoma. Int J Oncol, 2006, 28:767-773.
9. Jürgen RF, Ute O, Norman R, et al. Prognostic significance of RASSF1 A promoter methylation on survival of non-small cell lung cancer patients treated with gemcitabine. Lung Cancer, 2007, 56: 115-123.
10. Luke BH, Wendy NC, Farida L. The role of RASSF1 A methylation in cancer. Dis Markers, 2007, 23:73-87.