Hemolytic anemia due to warm autoantibodies

Blood Reviews

Volumn 22, Issue 1, 2008, Pages 17-31

  Packman, Charles H ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b CAROLINAS MEDICAL CENTER   (United States)

Author keywords

Autoantibodies; Complement; Coombs test; Direct antiglobulin test; Hemolytic anemia; Immunoglobulin; Reticulocytes; Spherocytes

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; CEFOTETAN; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DANAZOL; GAMMA GLOBIN; GLUCOCORTICOID; HAPTOGLOBIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENT; LACTATE DEHYDROGENASE; MERCAPTOPURINE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RITUXIMAB; TIOGUANINE; UROBILINOGEN;

ANEMIA; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE HEMOLYTIC ANEMIA; BILIRUBIN BLOOD LEVEL; BLOOD TRANSFUSION; COMPLEMENT FACTOR; COOMBS TEST; DEMOGRAPHY; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DRUG DOSE REDUCTION; ERYTHROCYTE DISORDER; ERYTHROCYTE LIFESPAN; ERYTHROCYTE TRANSFUSION; FOLLOW UP; HEMOLYTIC ANEMIA; HUMAN; LACTATE DEHYDROGENASE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN URINE LEVEL; REMISSION; RETICULOCYTE; RETICULOCYTOSIS; SPLENECTOMY;

ANEMIA, HEMOLYTIC; AUTOANTIBODIES; BLOOD TRANSFUSION; COOMBS' TEST; HUMANS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; SPHEROCYTES; SPLENECTOMY; TEMPERATURE;

EID: 38749084916     PISSN: 0268960X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.blre.2007.08.001     Document Type: Article

References (129)

1. Packman C. Historical Review: The Spherocytic Haemolytic Anaemias. Br J Haematol 112 (2003) 888-899
2. Coombs R.R.A., Mourant A.E., and Race E.E. Detection of weak and "incomplete" Rh agglutinins: A new test. Lancet ii 246 (1945) 15-16
3. Moreschi C. Neue tatsachen uber blutkorperchenagglutination. Zentralbl Bacteriol Parasitenkd Infektkr Originale 46 (1908) 49-51
4. Coombs R.R.A., Mourant A.E., and Race R.R. A new test for the detection of weak and 'incomplete' Rh agglutinins. British Journal of Experimental Pathology 26 (1945) 255-266
5. Boorman K.E., Dodd B.E., and Loutit J.F. Haemolytic icterus (acholuric jaundice), congenital and acquired. Lancet 1 (1946) 812-814
6. Loutit J.F., and Mollison P.L. Haemolytic icterus (acholuric jaundice), congenital and acquired. J Pathol Bacteriol 58 (1946) 711-728
7. Petz L.D., and Garratty G. Acquired Immune Hemolytic Anemias (1980), Churchill Livingstone, London
8. Pirofsky B. Hereditary aspects of autoimmune hemolytic anemia: A retrospective analysis. Vox Sang 14 (1968) 334-347
9. Dobbs C.E. Familial auto-immune hemolytic anemia. Arch Intern Med 116 (1965) 273-276
10. Cordova M.S., Baez-Villasenor J., Mendez J.J., and Campos E. Acquired hemolytic anemia with positive antiglobulin (Coombs' test) in mother and daughter. Arch Intern Med 117 (1966) 692-695
11. Dacie J.V. The Haemolytic Anaemias. The Autoimmune Haemolytic Anaemias. 3d ed. vol. 3 (1992), Churchill Livingstone, New York
12. Sokol R.J., Hewitt S., and Stamps B.K. Autoimmune haemolysis: An 18 year study of 865 cases referred to a regional transfusion centre. Br Med J 282 (1981) 2023-2027
13. Sokol R.J., Hewitt S., and Stamps B.K. Autoimmune haemolysis: Mixed warm and cold antibody type. Acta Haematol 69 (1983) 266-274
14. Shulman I.A., Branch D.R., Nelson J.M., Thompson J.C., Saxena S., and Petz L.D. Autoimmune hemolytic anemias with both cold and warm autoantibodies. JAMA 253 (1985) 1746-1748
15. Kajii E., Miura Y., and Ikemoto S. Characterization of autoantibodies in mixed-type autoimmune hemolytic anemia. Vox Sang 60 (1991) 45-52
16. Berentsen S., Bo K., Shammas F., Myking A., and Ulvestad E. Chronic cold agglutinin disease of the "idiopathic" type is a premalignant or low-grade malignant lymphoproliferative disease. APMIS 105 (1997) 354-362
17. Telen M.J., Roberts K.B., and Bartlett J.A. HIV-associated autoimmune hemolytic anemia: Report of a case and review of the literature. J Acquir Immune Defic Syndr 3 (1990) 933-937
18. Rapoport A.P., Rowe J.M., and McMican A. Life-threatening autoimmune hemolytic anemia in patient with acquired immune deficiency syndrome. Transfusion 28 (1988) 190-191
19. Saif M. HIV Associated Autoimmune Hemolytic Anemia: An Update. AIDS Patient Care 15 (2001) 217-224
20. Habibi B., Basty R., Chodez S., and Prunat A. Thiopental-related immune hemolytic anemia and renal failure. N Engl J Med 312 (1985) 353-355
21. Habibi B. Drug-induced red blood cell autoantibodies co-developed with drug-specific antibodies causing a hemolytic anaemia. Br J Haematol 61 (1985) 139-143
22. a. Transfusion 24 (1984) 206-209
23. Salama A., and Mueller-Eckhardt C. Rh blood group-specific antibodies in immune hemolytic anemia induced by nomifensine. Blood 68 (1986) 1285-1288
24. Salama A., and Mueller-Eckhardt C. On the mechanisms of sensitization and attachment of antibodies to RBC in drug-induced immune hemolytic anemia. Blood 69 (1987) 1006-1010
25. Arndt P., and Garratty G. Cross-Reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other cephalosporins and penicillin. Am J Clin Pathol 118 (2002) 256-2002
26. Weiss R., Freiman J., Kweder S., Diehl L.F., and Byrd J.C. Hemolytic anemia after fludarabine therapy for chronic lymphocytic leukemia. J Clin Oncol 16 (1998) 1885-1889
27. Chasty R.C., Myint H., Oscier D.G., Orchard J.A., Bussutil D.P., and Hamon M.D. Autoimmune haemolysis in patients with B-CLL treated with chlorodeoxyadenosine (CDA). Leuk Lymphoma 29 (1998) 391-398
28. Worlledge S.M. Immune drug-induced haemolytic anaemias. Semin Hematol 6 (1969) 181-200
29. Leddy J.P., Falany J.L., Kissel G.E., Passodor S.T., and Rosenfeld S.I. Erythrocyte membrane proteins reactive with human (warm-reacting) anti-red cell autoantibodies. J Clin Invest 91 (1993) 1672-1680
30. Mollison P.L. Measurement of survival and destruction of red cells in haemolytic syndromes. Br Med Bull 15 (1959) 59-67
31. Crowley L.V., and Bouroncle B.A. Studies on the specificity of autoantibodies in acquired hemolytic anemia. Blood 11 (1956) 700-707
32. Chaplin H., Cohen R., Bloomberg G., Kaplan H.J., Moore J.A., and Dorner I. Pregnancy and idiopathic autoimmune haemolytic anaemia: A prospective study during 6 months gestation and 3 months "post-partum". Br J Haematol 24 (1973) 219-229
33. Mollison P.L., Crome P., Hughes-Jones N.C., and Rochna E. Rate of removal from the circulation of red cells sensitized with different amounts of antibody. Br J Haematol 11 (1965) 461-470
34. Mollison P.L., and Hughes-Jones N.C. Clearance of Rh-positive red cells by low concentration of Rh antibody. Immunology 12 (1967) 63-73
35. Rosse W.F. Quantitative immunology of immune hemolytic anemia: II. The relationship of cell-bound antibody to hemolysis and the effect of treatment. J Clin Invest 50 (1971) 734-743
36. Schreiber A.D., and Frank M.M. Role of antibody and complement in the immune clearance and destruction of erythrocytes: I. In vivo effects of IgG and IgM complement-fixing sites. J Clin Invest 51 (1972) 575-582
37. Atkinson J.P., Schreiber A.D., and Frank M.M. Effects of corticosteroids and splenectomy on the immune clearance and destruction of erythrocytes. J Clin Invest 52 (1973) 1509-1517
38. Atkinson J.P., and Frank M.M. Complement independent clearance of IgG sensitized erythrocytes: Inhibition by cortisone. Blood 44 (1974) 629-637
39. Jandl J.H., Richardson-Jones A., and Castle W.B. The destruction of red cells by antibodies in man: I. Observations on the sequestration and lysis of red cells altered by immune mechanisms. J Clin Invest 36 (1957) 1428-1459
40. Jandl J.H., and Kaplan M.E. The destruction of red cells by antibodies in man: III. Quantitative factors influencing the pattern of hemolysis in vivo. J Clin Invest 39 (1960) 1145-1156
41. Anderson C.L., and Looney R.J. Human leukocyte IgG Fc receptors. Immunol Today 7 (1986) 264
42. Ravetch J.V., and Kinet J.-P. Fc receptors. Annu Rev Immunol 9 (1991) 457-492
43. Gigli I., and Nelson R.A. Complement-dependent immune phagocytosis: I. Requirements of C1, C4, C2, C3. Exp Cell Res 51 (1968) 45-67
44. Lay W.F., and Nussenzweig V. Receptors for complement on leukocytes. J Exp Med 128 (1968) 991-1009
45. Ross G.D. Opsonization and membrane complement receptors. In: Ross G.D. (Ed). Immunobiology of the Complement System (1986), Academic Press, Orlando 87
46. Fischer J.T., Petz L.D., Garratty G., and Cooper N.R. Correlations between quantitative assay of red cell bound C3, serologic reactions, and hemolytic anemia. Blood 44 (1974) 359-373
47. Schreiber A.D., Parsons J., McDermott P., and Cooper R.A. Effect of corticosteroids on the human monocyte IgG and complement receptors. J Clin Invest 56 (1975) 1189-1197
48. Ehlenberger A.G., and Nussenzweig V. The role of membrane receptors for C3b and C3d in phagocytosis. J Exp Med 145 (1977) 357-371
49. Abramson N., LoBuglio A.F., Jandl J.H., and Cotran R.S. The interaction between human monocytes and red cells: Binding characteristics. J Exp Med 132 (1970) 1191-1206
50. LoBuglio A.F., Cotran R.S., and Jandl J.H. Red cells coated with immunoglobulin G: Binding and sphering by mononuclear cells in man. Science 158 (1967) 1582-1585
51. Rosse W.F., de Boisfleury A., and Bessis M. The interaction of phagocytic cells and red cells modified by immune reactions: Comparison of antibody and complement coated red cells. Blood Cells 1 (1975) 345-358
52. Dameshek W., and Schwartz S.O. Acute hemolytic anemia (acquired hemolytic icterus, acute type). Medicine 19 (1940) 231-327
53. Leddy J.P., and Rosenfeld S.I. Role of complement in hemolytic anemia and thrombocytopenia. In: Ross G.D. (Ed). Immunobiology of the Complement System (1986), Academic Press, Orlando 213
54. Evans R.S., and Duane R.T. Acquired hemolytic anemia: I. The relation of erythrocyte antibody production to activity of the disease. II. The significance of thrombocytopenia and leukopenia. Blood 4 (1949) 1196-1213
55. Evans R.S., Takahashi K., Duane R.T., Payner R., and Liu C. Primary thrombocytopenic purpura and acquired hemolytic anemia: Evidence for a common etiology. Arch Intern Med 87 (1951) 48-65
56. Pegels J.G., Helmerhorst F.M., vanLeeuwen E.F., van de Plas-van Dalen C., Engelfriet C.P., and von dem Borne A.E. The Evans syndrome: Characterization of the responsible autoantibodies. Br J Haematol 51 (1982) 445-450
57. Liesveld J.L., Rowe J.M., and Lichtman M.A. Variability of the erythropoietic response in autoimmune hemolytic anemia: Analysis of 109 cases. Blood 69 (1987) 820-826
58. Hegde U.M., Gordon-Smith E.C., and Worlledge S.M. Reticulocytopenia and absence of red cell autoantibodies in immune haemolytic anaemia. Br Med J 2 (1977) 1444-1447
59. Conley C.L., Lippman S.M., and Ness P. Autoimmune hemolytic anemia with reticulocytopenia: A medical emergency. JAMA 244 (1980) 1688-1690
60. Greenberg J., Curtis-Cohen M., Gill F.M., and Cohen A. Prolonged reticulocytopenia in autoimmune hemolytic anemia of childhood. J Pediatr 97 (1980) 784-786
61. Eyster M.E., and Jenkins Jr. D.E. Erythrocyte coating substances in patients with positive direct antiglobulin reactions: Correlation of γG globulin and complement coating with underlying diseases, overt hemolysis and response to therapy. Am J Med 46 (1969) 360-371
62. Leddy J.P. Immunological aspects of red cell injury in man. Semin Hematol l 3 (1966) 48-73
63. Engelfriet C.P., von dem Borne A.E.G.Kr., Vander Giessen M., Beckers D., and van Loghem J.J. Autoimmune haemolytic anaemias: I. Serological studies with pure anti-immunoglobulin reagents. Clin Exp Immunol 3 (1968) 605-614
64. Engelfriet C.P., von dem Borne A.E.G.Kr., Beckers D., and van Loghem J.J. Autoimmune haemolytic anaemia: Serological and immunochemical characteristics of the autoantibodies: Mechanisms of cell destruction. Ser Haematol 7 (1974) 328-347
65. Suzuki S., Amano T., Mitsunaga M., Yagyu F., and Ofuji T. Autoimmune hemolytic anemia associated with IgA autoantibody. Clin Immunol Immunopathol 21 (1981) 247-256
66. Wolf C.F., Wolf D.J., Peterson P., Brandstetter R.D., and Hansen D.E. Autoimmune hemolytic anemia with predominance of IgA autoantibody. Transfusion 22 (1982) 238-240
67. Szymanski I.O., Teno R., and Rybak M.E. Hemolytic anemia due to a mixture of low-titer IgG lambda and IgM lambda agglutinins reacting optimally at 22 °C. Vox Sang 51 (1986) 112-116
68. Reusser P., Osterwalder B., Burri H., and Speck B. Autoimmune hemolytic anemia associated with IgA: Diagnostic and therapeutic aspects in a case with long-term follow-up. Acta Haematol 77 (1987) 53-56
69. Göttsche B., Salama A., and Mueller-Eckhardt C. Autoimmune hemolytic anemia associated with an IgA autoanti-Gerbich. Vox Sang 58 (1990) 211-214
70. Evans R.S., Bingham M., and Boehni P. Autoimmune hemolytic disease: Antibody dissociation and activity. Arch Intern Med 108 (1961) 338-352
71. Evans R.S., Bingham M., and Turner E. Autoimmune hemolytic disease: Observations of serological reactions and disease activity. Ann NY Acad Sci 124 (1965) 422-440
72. Gilliland B.C., Leddy J.P., and Vaughan J.H. The detection of cell-bound antibody on complement-coated human red cells. J Clin Invest 49 (1970) 898-906
73. Gilliland B.C., Baxter E., and Evans R.S. Red cell antibodies in acquired hemolytic anemia with negative antiglobulin serum tests. N Engl J Med 285 (1971) 252-256
74. Gilliland B.C. Coombs-negative immune hemolytic anemia. Semin Hematol 13 (1976) 267-275
75. Sokol R.J., Hewitt S., Booker D.J., and Bailey A. Erythrocyte autoantibodies, subclasses of IgG and autoimmune haemolysis. Autoimmunity 6 (1990) 99-104
76. 4 autoantibodies against erythrocytes, without increased hemolysis: A case report. Br J Haematol 37 (1977) 137-144
77. b and other autoantibodies responsible for positive direct antiglobulin test in 150 individuals. Br J Haematol 34 (1976) 5-18
78. Weiner W., and Vos G.H. Serology of acquired hemolytic anemia. Blood 22 (1963) 606-613
79. Vos G.H., Petz L., and Funenberg H.H. Specificity of acquired haemolytic anaemia autoantibodies and their serological characteristics. Br J Haematol 19 (1970) 57-66
80. Leddy J.P., Peterson P., Yeaw M.A., and Bakemeier R.F. Patterns of serologic specificity of human γG erythrocyte autoantibodies. J Immunol 105 (1970) 677-686
81. Barker R.N., Casswell K.M., Reid M.E., Sokol R.J., and Elson C.J. Identification of autoantigens in autoimmune haemolytic anaemia by a non-radioisotope immunoprecipitation method. Br J Haematol 82 (1992) 126-132
82. b in warm autoimmune hemolytic anemia. Transfusion 18 (1978) 572-575
83. Celano M.J., and Levine P. Anti-LW specificity in autoimmune acquired hemolytic anemia. Transfusion 7 (1967) 265-268
84. Marsh W.L., Reid M.E., and Scott E.P. Autoantibodies of U blood group specificity in autoimmune haemolytic anaemia. Br J Haematol 22 (1972) 625-629
85. Shulman I.A., Vengelen-Tyler V., Thompson J.C., Nelson J.M., and Chen D.C. Autoanti-Ge associated with severe autoimmune hemolytic anemia. Vox Sang 59 (1990) 232-234
86. Owen I., Chowdhury V., Reid M.E., Poole J., Marsh J.C., and Hows J.M. Autoimmune hemolytic anemia associated with anti-Sc1. Transfusion 32 (1992) 173-176
87. Marsh W.L., Oyen R., Alicea E., Linter M., and Horton S. Autoimmune hemolytic anemia and the Kell blood groups. Am J Hematol 7 (1979) 155-162
88. Victoria E.J., Pierce S.W., Branks M.J., and Masouredis S.P. IgG red blood cell autoantibodies in autoimmune hemolytic anemia bind to epitopes on red blood cell membrane band 3 glycoprotein. J Lab Clin Med 115 (1990) 74-88
89. b antigen to an interaction between glycophorin A and band 3. Blood 76 (1990) 842-848
90. Lichtman M.A., Beutler E., Kipps T., Seligsohn U., and Kaushansky K. Prchal. Williams Hematology (2005), McGraw Hill, New York
91. Sokol R., Stamps R., Booker D., Scott F.M., Ladlaw S.T., and Vandenberghe E.A. Posttransplant immune-mediated hemolysis. Transfusion 42 (2002) 198-204
92. Lundgren G., Asaba H., Bergström J., Groth C.G., Magnusson G., and Moller E. Fulminating anti-A autoimmune hemolysis with anuria in a renal transplant recipient: A therapeutic role of plasma exchange. Clin Nephrol 16 (1981) 211-214
93. Ramsey G., Nusbacher J., Starzl T.E., and Lindsay G.D. Isohemagglutinins of graft origin after ABO-unmatched liver transplantation. N Engl J Med 311 (1984) 1167-1170
94. Mangal A.K., Growe G.H., Sinclair M., Stillwell G.F., Reeve C.E., and Naiman S.C. Acquired hemolytic anemia due to "auto"-anti-a or "auto"-anti-b induced by group O homograft in renal transplant recipients. Transfusion 24 (1984) 201-205
95. Hazlehurst G.R., Brenner M.K., Wimperis J.Z., Knowles Sm., and Prentice H.G. Haemolysis after T-cell depleted bone marrow transplantation involving minor ABO incompatibility. Scand J Haematol 37 (1986) 1-3
96. Solheim B.G., Albrechtsen D., Egeland T., Flatmark A., Fauchald P., and Froysaker T. Auto-antibodies against erythrocytes in transplant patients produced by donor lymphocytes. Transplant Proc 6 (1987) 4520-4521
97. Sniecinski I.J., Oien L., Petz L.D., and Blume K.G. Immunohematologic consequences of major ABO-mismatched bone marrow transplantation. Transplantation 45 (1988) 530-534
98. Issitt P.D. Autoimmune hemolytic anemia and cold hemagglutinin disease: Clinical disease and laboratory findings. Prog Clin Pathol 7 (1978) 137-163
99. Wallhermfechtel M.A., Pohl B.A., and Chaplin H. Alloimmunization in patients with warm autoantibodies. A retrospective study employing three donor alloabsorptions to aid in antibody detection. Transfusion 24 (1984) 482-485
100. Branch D.R., and Petz L.D. Detecting alloantibodies in patients with autoantibodies. Transfusion 39 (1999) 6-10
101. Greendyke R.M., Bradley E.B., and Swisher S.N. Studies of the effects of administration of ACTH and adrenal corticosteroids on erythrophagocytosis. J Clin Invest 44 (1965) 746-753
102. Fries L.F., Brickman C.M., and Frank M.M. Monocyte receptors for the Fc portion of IgG increase in number in autoimmune hemolytic anemia and other hemolytic states and are decreased by glucocorticoid therapy. J Immunol 131 (1983) 1240-1245
103. Allgood J.W., and Chaplin H.J. Idiopathic acquired autoimmune hemolytic anemia: A review of forty-seven cases treated from 1955 to 1965. Am J Med 43 (1967) 254-273
104. Meyer O., Stahl D., Beckhove P., Huhn D., and Salama A. Pulsed high-dose dexamethasone in chronic autoimmune haemolytic anaemia of warm type. Br J Haemotal 98 (1997) 860-862
105. Habibi B., Homberg J.C., Schaison G., and Salmon C. Autoimmune hemolytic anemia in children: A review of 80 cases. Am J Med 56 (1974) 61-69
106. Christensen B.E. The pattern of erythrocyte sequestration in immunohaemolysis: Effects of prednisone treatment and splenectomy. Scand J Haematol 10 (1973) 120-129
107. Parker A.C., MacPherson A.I.S., and Richmond J. Value of radiochromium investigation in autoimmune haemolytic anemia. Br Med J 1 (1977) 208-209
108. Bowdler A.J. The role of the spleen and splenectomy in autoimmune hemolytic disease. Semin Hematol 13 (1976) 335-348
109. Schwartz S.I., Bernard R.P., Adams J.T., and Bauman A.W. Splenectomy for hematologic disorders. Arch Surg 101 (1970) 338-347
110. Eichner E.R. Splenic function: Normal, too much and too little. Am J Med 66 (1979) 311320
111. Newland A., and Provan D. Preventing severe infection after splenectomy. Brit Med J 331 (2005) 20-27
112. Centers for Disease Control and Prevention: Recommended adult immunization schedule-United States, 2003-2004. MMWR 2003; 52:965-969.
113. Zecca M., Nobili B., Ramenghi U., Perrotta S., Amendola G., and Rosito P. Rituximab for the treatment of refractory autoimmune hemolytic anemia in children. Blood. 101 (2003) 3857-3861
114. Murphy S., and LoBuglio A.F. Drug therapy of autoimmune hemolytic anemia. Semin Hematol 13 (1976) 323-334
115. Moyo V.M., Smith D., Brodsky I., Crilley P., Jones R.J., and Brodsky R.A. High-dose cyclophosphamide for refractory autoimmune hemolytic anemia. Blood 100 (2002) 704-706
116. Emilia C., Messora C., Longo G., and Bertesi M. Long-term salvage treatment by cyclosporine in refractory autoimmune haematological disorders. Br J Haematol 93 (1996) 341-344
117. Howard J., Hoffbrand A.V., Prentice H.G., and Mehta A. Mycophenolate mofetil for the treatment of refractory auto-immune haemolytic anaemia and auto-immune thrombocytopenic purpura. Br J Haematol 117 (2002) 712-715
118. Fibich C., Schober C., and Schmoll H.-J. Treatment of refractory autoimmune hemolytic anemias with mycophenolate-mofetil (Cellcept) [abstract}. Br J Haematol 102 (1998) 39
119. Shumak K.H., and Rock G.A. Therapeutic plasma exchange. N Engl J Med 310 (1984) 762-771
120. Council Report: Current status of therapeutic plasmapheresis and related techniques. JAMA 1985; 253:819-825.
121. Flores G., Cunningham-Rundles C., Newland A.C., and Bussel J.B. Efficacy of intravenous immunoglobulin in the treatment of autoimmune hemolytic anemia: Results in 73 patients. Am J Hematol 44 (1993) 237-242
122. Ahn Y.S., Harrington W.J., Mylvaganam R., Ayub j., and Pall L.M. Danazol therapy for autoimmune hemolytic anemia. Ann Intern Med 102 (1985) 298-301
123. Pignon J.-M., Poirson E., and Rochant H. Danazol in autoimmune haemolytic anaemia. Br J Haematol 83 (1993) 343-345
124. Giannadaki E., Potamianos S., Roussomoustakaki M., Kyriakou D., Fragkiadakis S.N., and Manousos O.N. Autoimmune hemolytic anemia and positive Coombs test associated with ulcerative colitis. Am J Gastroenterol. 92 (1997) 1872-1874
125. Cobo F., Pereira A., Nomdedeu B., Gallart T., Ordi J., and Torne A. Ovarian dermoid cyst- associated autoimmune hemolytic anemia. Am J Clin Pathol. 105 (1996) 567-571
126. Sallah S., Wan J., and Hanrahan L. Future development of lymphoproliferative disorders in patients with autoimmune hemolytic anemia. Clin Cancer Res 7 (2001) 791-794
127. Dausset J., and Colombani J. The serology and the prognosis of 128 cases of autoimmune hemolytic anemia. Blood 14 (1959) 1280-1301
128. Pullarkat V., Ngo M., Iqbal S., Espina B., and Liebman H.A. Detection of lupus anticoagulant identifies patients with autoimmune haemolytic anaemia at increased risk of venous thromboemoblism. Brit J Haematol. 118 (2002) 1166-1169
129. Hendrick A.M. Auto-immune haemolytic anaemia - a high-risk disorder for thromboembolism?. Hematology 8 (2003) 53-56