Cross-reactivity of cefotetan and ceftriaxone antibodies, associated with hemolytic anemia, with other cephalosporins and penicillin

American Journal of Clinical Pathology

Volumn 118, Issue 2, 2002, Pages 256-262

  Arndt, Patricia A ^a   Garratty, George ^a  

^a AMERICAN RED CROSS BLOOD SERVICES   (United States)

Author keywords

Antibiotics; Cefotetan antibody; Ceftriaxone antibody; Cross reactivity; Drug induced immune hemolytic anemia

Indexed keywords

7 AMINOCEPHALOSPORANIC ACID; CEFAMANDOLE; CEFOPERAZONE; CEFOTETAN; CEFTRIAXONE; CEPHALOSPORIN; HAPTEN ANTIBODY; PENICILLIN G; 7-AMINOCEPHALOSPORANIC ACID; ANTIBODY; CEFALOTIN; CEFOTAXIME; CEFOXITIN; CEPHALOSPORIN DERIVATIVE; PENICILLIN DERIVATIVE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; DRUG INDUCED DISEASE; ERYTHROCYTE; HEMOLYTIC ANEMIA; HUMAN; IN VIVO STUDY; PRIORITY JOURNAL; CELL CULTURE; CHEMICAL MODEL; IMMUNOLOGY;

ANEMIA, HEMOLYTIC; ANTIBODIES; CEFAMANDOLE; CEFOPERAZONE; CEFOTAXIME; CEFOTETAN; CEFOXITIN; CEFTRIAXONE; CELLS, CULTURED; CEPHALOSPORINS; CEPHALOTHIN; CROSS REACTIONS; HUMANS; MODELS, CHEMICAL; PENICILLINS;

EID: 0036676580     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/JFJE-VUKN-221T-G6EV     Document Type: Article

References (47)

1. Garratty G. Drug-induced immune hemolytic anemia. In: Garratty G, ed. Immunobiology of Transfusion Medicine. New York, NY: Dekker; 1994:523-551.
2. Petz LD, Garratty G. Acquired Immune Hemolytic Anemias. New York, NY: Churchill Livingstone; 1980.
3. Garratty G. Immune cytopenia associated with antibiotics. Transfus Med Rev. 1993;7:255-267.
4. Arndt PA, Leger RM, Garratty G. Serology of antibodies to second- and third-generation cephalosporins associated with immune hemolytic anemia and/or positive direct antiglobulin tests. Transfusion. 1999;39:1239-1246.
5. Manoharan A, Kot T. Cephalexin-induced haemolytic anaemia [letter]. Med J Aust. 1987;147:202.
6. Badon SJ, Cable RG, Gunderia HV. Hemolysis due to cefotetan [abstract]. Transfusion. 1999;39:42S.
7. Johnson ST, Fueger JT, Gottschall JL. Cefotetan-dependent antibody cross-reacting with ceftriaxone treated RBCs [abstract]. Transfusion. 1999;39:81S.
8. Stroncek D, Procter JL, Johnson J. Drug-induced hemolysis: cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction. Am J Hematol. 2000;64:67-70.
9. Naylor CS, Steele L, Hsi R, et al. Cefotetan-induced hemolysis associated with antibiotic prophylaxis for cesarean delivery. Am J Obstet Gynecol 2000;182:1427-1428.
10. Moes S, MacPherson BR. Cefotetan-induced hemolytic anemia. Arch Pathol Lab Med. 2000;124:1344-1346.
11. Marques MB, Carr KD, Brumfield CG, et al. A pregnant patient with sickle cell disease and cefotetan-induced hemolysis. Lab Med. 2000;31:541-543.
12. Ray EK, Warkentin TE, O'Hoski PL, et al. Delayed onset of life-threatening immune hemolysis after perioperative antimicrobial prophylaxis with cefotetan. Can J Surg. 2000;43:461-462.
13. Chai L, Pomper GJ, Ross RL, et al. Severe hemolytic anemia and liver damage induced by prophylactic use of cefotetan [abstract]. Transfusion. 2001;41:58S.
14. Longo F, Hastier P, Buckley MJM, et al. Acute hepatitis, autoimmune hemolytic anemia, and erythroblastocytopenia induced by ceftriaxone. Am J Gastroenterol. 1998;93:836-837.
15. Maraspin V, Lotric-Furlan S, Strle F. Ceftriaxone associated hemolysis. Wien Klin Wochenschr. 1999;9:368-370.
16. Meyer O, Hackstein H, Hoppe B, et al. Fatal immune haemolysis due to a degradation product of ceftriaxone. Br J Haematol 1999;105:1084-1085.
17. Viner Y, Hashkes PJ, Yakubova R, et al. Severe hemolysis induced by ceftriaxone in a child with sickle-cell anemia. Pediatr Infect Dis J. 2000;19:83-85.
18. Seltsam A, Salama A. Ceftriaxone-induced immune haemolysis: two case reports and a concise review of the literature. Intensive Care Med. 2000;26:1390-1394.
19. Falezza GC, Piccoli PL, Franchini M, et al. Ceftriaxone-induced hemolysis in an adult. Transfusion. 2000;40:1543-1545.
20. Fueger JT, Bell JA, Gottschall JL, et al. Ceftazidime-dependent antibody reacting with untreated red cells in the presence of drug [abstract]. Transfusion. 2001;41:104S.
21. Shammo JM, Calhoun B, Mauer AM, et al. First two cases of immune hemolytic anemia associated with ceftizoxime. Transfusion. 1999;39:838-844.
22. Endoh T, Yagihashi A, Sasaki M, et al. Ceftizoxime-induced hemolysis due to immune complexes: case report and determination of the epitope responsible for immune complex-mediated hemolysis. Transfusion. 1999;39:306-309.
23. Calhoun BW, Junsanto T, De Tolve Donoghue M, et al. Ceftizoxime-induced hemolysis secondary to combined drug adsorption and immune-complex mechanisms. Transfusion. 2001;41:893-897.
24. Garratty G, Postoway N, Schwellenbach J, et al. A fatal case of ceftriaxone (Rocephin)-induced hemolytic anemia associated with intravascular immune hemolysis. Transfusion. 1991;31:176-179.
25. Eckrich RJ, Fox S, Mallory D. Cefotetan-induced immune hemolytic anemia due to the drug-adsorption mechanism. Immunohematology 1994;10:51-54.
26. Ogburn JR, Knauss MA, Thapar K, et al. Cefotetan-induced immune hemolytic anemia (IHA) resulting from both drug adsorption and immune complex mechanisms [abstract]. Transfusion. 1994;34:27S.
27. Chenoweth CE, Judd WJ, Steiner EA, et al. Cefotetan-induced immune hemolytic anemia. Clin Infect Dis. 1992;15:863-865.
28. Gallagher NI, Schergen AK, Sokol-Anderson ML, et al. Severe immune-mediated hemolytic anemia secondary to treatment with cefotetan. Transfusion. 1992;32:266-268.
29. Garratty G, Nance S, Lloyd M, et al. Fatal immune hemolytic anemia due to cefotetan. Transfusion. 1992;32:269-271.
30. Spath P, Garratty G, Petz L. Studies on the immune response to penicillin and cephalothin in humans, I: optimal conditions for titration of hemagglutinating penicillin and cephalothin antibodies. J Immunol. 1971;107:854-859.
31. Petz LD, Branch DR. Drug-induced immune hemolytic anemia. In: Chaplin H, ed. Methods in Hematology: Immune Hemolytic Anemias. New York, NY: Churchill Livingstone; 1985:47-94.
32. Petersen BH, Graham J. Immunologic cross-reactivity of cephalexin and penicillin. J Lab Clin Med. 1974;83:860-870.
33. Garratty G, Arndt P, Nance S. Nonimmunological adsorption of proteins onto red cells treated with second and third generation cephalosporins [abstract]. Transfusion. 1994;34:69S.
34. Abraham NC, Petz LD, Fudenberg HH. Cephalothin hypersensitivity associated with anti-cephalothin antibodies. Int Arch Allergy Appl Immunol. 1968;34:65-74.
35. Assem ESK, Vickers MR. Tests for penicillin allergy in man, II: the immunological cross-reaction between penicillins and cephalosporins. Immunology. 1964;27:255-269.
36. Grieco AM. Cross-allergenicity of the penicillins and the cephalosporins. Arch Intern Med. 1967;119:141-145.
37. Anderson JA. Cross-sensitivity to cephalosporins in patients allergic to penicillin. J Infect Dis. 1986;5:557-561.
38. Petz LD. Immunologic cross-reactivity between penicillin and cephalosporins: a review. J Infect Dis. 1978;137(suppl):S74-S79.
39. Anne S, Reisman RE. Risk of administering cephalosporin antibiotics to patients with histories of penicillin allergy. Ann Allergy Asthma Immunol. 1995;74:167-170.
40. Novalbos A, Sastre J, Cuesta J, et al. Lack of allergic cross-reactivity to cephalosporins among patients allergic to penicillins. Clin Exp Allergy. 2001;31:438-443.
41. Mandell GL, Petri WA Jr. Antimicrobial agents: penicillins, cephalosporins, and other beta-lactam antibiotics. In: Hardman JG, Limbird LE, Molinoff PB, et al, eds. Goodman & Gilman's the Pharmacological Basis of Therapeutics. 9th ed. New-York, NY: McGraw-Hill; 1996:1090-1091.
42. O'Neil MJ, ed. The Merck Index. 13th ed. Whitehouse Station, NJ: Merck; 2001:77, 1272.
43. Hamilton-Miller JMT, Abraham EP. Specificities of haemagglutinating antibodies evoked by members of the cephalosporin C family and benzylpenicillin. Biochem J. 1971;123:183-190.
44. Delafuente JC, Panush RS, Caldwell JR. Penicillin and cephalosporin immunogenicity in man. Ann Allergy. 1979;43:337-340.
45. Cerny A, Pichler W. Allergy to antibacterials: the problem with beta-lactams and sulfonamides. Pharmacoepidemiol Drug Saf. 1998;7:S23-S36.
46. Petz LD. Immunologic reactions of humans to cephalosporins. Postgrad Med J. 1971;47:64-69.
47. Spath P, Garratty G, Petz L. Studies on the immune response to penicillin and cephalothin in humans, II: immunohematologic reactions to cephalothin administration. J Immunol. 1971;107:860-869.