α-Phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced neuronal injury in the neonatal rat brain

Neuroscience

Volumn 151, Issue 3, 2008, Pages 737-744

  Fan, L W ^a   Mitchell, H J ^a   Rhodes, P G ^a   Cai, Z ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

antioxidant; microglial activation; neuronal injury; oxidative stress; tyrosine hydroxylase

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; AMYLOID PRECURSOR PROTEIN; LIPOPOLYSACCHARIDE; MALONALDEHYDE; N TERT BUTYL ALPHA PHENYLNITRONE; SODIUM CHLORIDE; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; BRAIN CORTEX; BRAIN NERVE CELL; CELL ACTIVATION; CELL NUCLEUS; CONTROLLED STUDY; FEMALE; MALE; MICROGLIA; NERVE CELL LESION; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD11B; AXONS; BRAIN INJURIES; CEREBRAL VENTRICLES; CYCLIC N-OXIDES; DENDRITES; FEMALE; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE 3-MONOOXYGENASE;

EID: 38749084515     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.09.087     Document Type: Article

References (39)

1. Abramov A.Y., Canevari L., and Duchen M.R. Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 24 (2004) 565-575
2. Babior B.M. NADPH Oxidase: An update. Blood 93 (1999) 1464-1476
3. Banker B.Q., and Larroche J.C. Periventricular leukomalacia of infancy. Arch Neurol 7 (1962) 386-410
4. Cai Z., Pang Y., Lin S., and Rhodes P.G. Differential roles of tumor necrosis factor-alpha and interleukin-1 beta in lipopolysaccharide-induced brain injury in the neonatal rat. Brain Res 975 (2003) 37-47
5. Chao C.C., Hu S., Molitor T.W., Shaskan E.G., and Peterson P.K. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149 (1992) 2736-2741
6. Choi S.H., Lee D.Y., Chung E.S., Hong Y.B., Kim S.U., and Jin B.K. Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo. J Neurochem 95 (2005) 1755-1765
7. Colton C.A., and Gilbert D.L. Microglia, an in vivo source of reactive oxygen species in the brain. Adv Neurol 59 (1993) 321-326
8. Deguchi K., Oguchi K., Matsuura N., Armstrong D.D., and Takashima S. Periventricular leukomalacia: relation to gestational age and axonal injury. Pediatr Neurol 20 (1999) 370-374
9. DeReuck J., Chattha A.S., and Richardson E.P. Pathologenesis and evolution of periventricular leukomalacia. Arch Neurol 27 (1972) 229-236
10. Endoh H., Kato N., Fujii S., Suzuki Y., Sato S., Kayama T., Kotake Y., and Yoshimura T. Spin trapping agent, phenyl N-tert-butylnitrone, reduces nitric oxide production in the rat brain during experimental meningitis. Free Radic Res 35 (2001) 583-391
11. Fan L.W., Pang Y., Lin S., Rhodes P.G., and Cai Z. Minocycline attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain. Neuroscience 133 (2005) 1359-1368
12. Fan L.W., Pang Y., Lin S., Tien L.T., Ma T., Rhodes P.G., and Cai Z. Minocycline reduces lipopolysaccharide-induced neurological dysfunction and brain injury in the neonatal rat. J Neurosci Res 82 (2005) 71-82
13. Floyd R.A., Hensley K., and Bing G. Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics. J Neural Transm Suppl 60 (2000) 387-414
14. Floyd R.A., Hensley K., Forster M.J., Kelleher-Anderson J.A., and Wood P.L. Nitrones as neuroprotectants and antiaging drugs. Ann N Y Acad Sci 959 (2002) 321-329
15. Floyd R.A., and Hensley K. Nitrone inhibition of age-associated oxidative damage. Ann N Y Acad Sci 899 (2000) 222-237
16. Green A.R., Ashwood T., Odergren T., and Jackson D.M. Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059. Pharmacol Ther 100 (2003) 195-214
17. Hagberg H., Peebles D., and Mallard C. Models of white matter injury: comparison of infectious, hypoxic-ischemic, and excitotoxic insults. Ment Retard Dev Disabil Res Rev 8 (2002) 30-38
18. Haynes R.L., Baud O., Li J., Kinney H.C., Volpe J.J., and Folkerth D.R. Oxidative and nitrative injury in periventricular leukomalacia: a review. Brain Pathol 15 (2005) 225-233
19. Haynes R.L., Folkerth R.D., Keefe R.J., Sung I., Swzeda L.I., Rosenberg P.A., Volpe J.J., and Kinney H.C. Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J Neuropathol Exp Neurol 62 (2003) 441-450
20. Inder T.E., Huppi P.S., Warfield S., Kikinis R., Zientara G.P., Barnes P.D., Jolesz F., and Volpe J.J. Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term. Ann Neurol 46 (1999) 755-760
21. Kadhim H., Tabarki B., De Prez C., and Sebire G. Cytokine immunoreactivity in cortical and subcortical neurons in periventricular leukomalacia: are cytokines implicated in neuronal dysfunction in cerebral palsy?. Acta Neuropathol (Berl) 105 (2003) 209-216
22. Kooy N.W., Lewis S.J., Royall J.A., Ye Y.Z., Kelly D.R., and Beckman J.S. Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite. Crit Care Med 25 (1997) 812-819
23. Kopnisky K.L., Sumners C., and Chandler L.J. Cytokine and endotoxin induced nitric oxide synthase in rat astroglial cultures: differential and modulation by angiotensin II. J Neurochem 68 (1997) 935-944
24. Kotake Y., Sang H., Miyajima T., and Wallis G.L. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta 1448 (1998) 77-84
25. Lee J.H., and Park J.W. The effect of alpha-phenyl-N-t-butylnitrone on ionizing radiation-induced apoptosis in U937 cells. Free Radic Res 39 (2005) 1325-1333
26. Lin S., Cox H.J., Rhodes P.G., and Cai Z. Neuroprotection of alpha-phenyl-n-tert-butyl-nitrone on the neonatal white matter is associated with anti-inflammation. Neurosci Lett 405 (2006) 52-56
27. Lin S., Rhodes P.G., Lei M., Zheng F., and Cai Z. alpha-Phenyl-n-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain. Brain Res 1007 (2004) 132-141
28. Ling Z., Gayle D.A., Ma S.Y., Lipton J.W., Tong C.W., Hong J.S., and Carvey P.M. In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. Mov Disord 17 (2002) 116-124
29. Li P.A., He Q.P., Nakamura L., and Csiszar K. Free radical spin trap alpha-phenyl-N-tert-butyl-nitrone inhibits caspase-3 activation and reduces brain damage following a severe forebrain ischemic injury. Free Radic Biol Med 31 (2001) 1191-1197
30. Meng S.Z., Arai Y., Deguchi K., and Takashima S. Early detection of axonal and neuronal lesions in prenatal-onset periventricular leukomalacia. Brain Dev 19 (1997) 480-484
31. Pang Y., Cai Z., and Rhodes P.G. Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide. Brain Res Dev Brain Res 140 (2003) 205-214
32. Qin L., Block M.L., Liu Y., Bienstock R.J., Pei Z., Zhang W., Wu X., Wilson B., Burka T., and Hong J.S. Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J 19 (2005) 550-557
33. Qin L., Liu Y., Wang T., Wei S.J., Block M.L., Wilson B., Liu B., and Hong J.S. NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem 279 (2004) 1415-1421
34. Rezaie P., and Dean A. Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. Neuropathology 22 (2002) 106-132
35. Sang H., Wallis G.L., Stewart C.A., and Kotake Y. Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl N-tert-butylnitrone (PBN). Arch Biochem Biophys 363 (1999) 341-348
36. Sheriff F.E., Bridges L.R., Gentleman S.M., Sivaloganathan S., and Wilson S. Marker of axonal injury in postmortem human brain. Acta Neuropathol 88 (1994) 433-440
37. Thorburne S.K., and Juurlink B.H. Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress. J Neurochem 67 (1996) 1014-1022
38. Uehara H., Yoshioka H., Kawase S., Nagai H., Ohmae T., Hasegawa K., and Sawada T. A new model of white matter injury in neonatal rats with bilateral carotid artery occlusion. Brain Res 837 (1999) 213-220
39. Volpe J.J. Cerebral white matter injury of the premature infant-more common than you think. Pediatrics 112 (2003) 176-180