Characterization of a new liver- and kidney-specific pfkfb3 isozyme that is downregulated by cell proliferation and dedifferentiation

Biochemical and Biophysical Research Communications

Volumn 367, Issue 4, 2008, Pages 748-754

  Duran, Joan ^a   Gómez, Marta ^a   Navarro Sabate, Aurea ^a   Riera Sans, Lluís ^b   Obach, Mercè ^a   Manzano, Anna ^a   Perales, Jose C ^a   Bartrons, Ramon ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

Author keywords

6 Phosphofructo 2 kinase fructose 2,6 bisphosphatase; Alternative splicing; Dedifferentiation; Fructose 2,6 bisphosphate; Hepatocytes; Isoform; Isozyme; Proliferation

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; FRUCTOSE 2,6 BISPHOSPHATASE; ISOENZYME; PFKFB3 PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENE EXPRESSION; GENETIC VARIABILITY; KIDNEY; LIVER; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DOWN-REGULATION; HEPATOCYTES; ISOENZYMES; KIDNEY; MALE; ORGAN SPECIFICITY; PHOSPHOFRUCTOKINASE-2; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

RATTUS;

EID: 38649137684     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.01.005     Document Type: Article

References (30)

1. Van Schaftingen E. Fructose 2,6-bisphosphate. Adv. Enzymol. Relat. Areas Mol. Biol. 59 (1987) 315-395
2. Pilkis S.J., Claus T.H., Kurland I.J., and Lange A.J. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu. Rev. Biochem. 64 (1995) 799-835
3. Wu C., Khan S.A., Peng L.J., and Lange A.J. Roles for Fructose 2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes. Adv. Enzyme Regul. 46 (2006) 72-88
4. Okar D.A., Manzano A., Navarro-Sabaté A., Riera Ll., Bartrons R., and Lange A.J. PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose 2,6-bisphosphate. Trends Biochem. Sci. 26 (2001) 30-35
5. Rider M.H., Bertrand L., Vertommen D., Michels P.A., Rousseau G.G., and Hue L. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Biochem. J. 381 Pt 3 (2004) 561-579
6. Goren N., Manzano A., Riera L., Ambrosio S., Ventura F., and Bartrons R. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase expression in rat brain during development. Brain Res. Mol. Brain Res. 75 1 (2000) 138-142
7. Chesney J., Mitchell R., Benigni R., Bacher M., Spiegel L., Al-Abed Y., Han J.H., Metz C., and Bucala R. An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect. Proc. Natl. Acad. Sci. USA 96 (1999) 3047-3052
8. Riera L., Manzano A., Navarro-Sabaté A., Perales J.C., and Bartrons R. Insulin induces PFKFB3 gene expression in HT29 human colon adenocarcinoma cells. Biochim. Biophys. Acta 1589 2 (2002) 89-92
9. Atsumi T., Chesney J., Metz C., Leng L., Donnelly S., Makita Z., Mitchell R., and Bucala R. High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Res. 62 20 (2002) 5881-5887
10. Ventura F., Ambrosio S., Bartrons R., el-Maghrabi M.R., Lange A.J., and Pilkis S.J. Cloning and expression of a catalytic core bovine brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Biochem. Biophys. Res. Commun. 209 3 (1995) 140-148
11. Manzano A., Rosa J.L., Ventura F., Perez J.X., Nadal M., Estivill X., Ambrosio S., Gil J., and Bartrons R. Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3). Cytogenet. Cell Genet. 83 (1998) 214-217
12. Sakai A., Kato M., Fukasawa M., Ishiguro M., Furuya E., and Sakakibara R. Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. J. Biochem. (Tokyo) 119 (1996) 506-511
13. Hamilton J.A., Callaghan M.J., Sutherland R.L., and Watts C.K. Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Mol. Endocrinol. 11 (1997) 490-502
14. Sakakibara R., Kato M., Okamura N., Nakagawa T., Komada Y., Tominaga N., Shimojo M., and Fukasawa M. Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase. J. Biochem. (Tokyo) 122 (1997) 122-128
15. Chesney J., Telang S., Yalcin A., Clem A., Wallis N., and Bucala R. Targeted disruption of inducible 6-phosphofructo-2-kinase results in embryonic lethality. Biochem. Biophys. Res. Commun. 331 1 (2005) 139-146
16. Duran J., Navarro-Sabate A., Pujol A., Perales J.C., Manzano A., Obach M., Gómez M., and Bartrons R. Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain. Biochem. Biophys. Res. Commun. 365 2 (2008) 291-297
17. Minchenko A., Leshchinsky I., Opentanova I., Sang N., Srinivas V., Armstead V., and Caro J. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J. Biol. Chem. 277 8 (2002) 6183-6187
18. Obach M., Navarro-Sabaté A., Caro J., Kong X., Duran J., Gómez M., Perales J.C., Ventura F., Rosa J.L., and Bartrons R. 6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia. J. Biol. Chem. 279 51 (2004) 53562-53570
19. Navarro-Sabaté A., Manzano A., Riera L., Rosa J.L., Ventura F., and Bartrons R. The human ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3): promoter characterization and genomic structure. Gene 264 1 (2001) 131-138
20. Watanabe F., Sakai A., and Furuya E. Novel isoforms of rat brain fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase are generated by tissue-specific alternative splicing. J. Neurochem. 69 1 (1997) 1-9
21. Watanabe F., and Furuya E. Tissue-specific alternative splicing of rat brain fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase. FEBS Lett. 458 3 (1999) 304-308
22. Kessler R., and Eschrich K. Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain. Brain Res. Mol. Brain Res. 87 2 (2001) 190-195
23. Bartrons R., Hue L., Van Schaftingen E., and Hers H.G. Hormonal control of fructose 2,6-bisphosphate concentration in isolated rat hepatocytes. Biochem. J. 214 3 (1983) 829-837
24. Coutant A., Rescan C., Gilot D., Loyer P., Guguen-Guillouzo C., and Baffet G. PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival. Hepatology 36 (2002) 1079-1088
25. Fassett J.T., Tobolt D., Nelsen C.J., Albrecht J.H., and Hansen L.K. The role of collagen structure in mitogen stimulation of ERK, cyclin D1 expression, and G1-S progression in rat hepatocytes. J. Biol. Chem. 278 34 (2003) 31691-31700
26. Band C.J., Mounier C., and Posner B.I. Epidermal growth factor and insulin-induced deoxyribonucleic acid synthesis in primary rat hepatocytes is phosphatidylinositol 3-kinase dependent and dissociated from protooncogene induction. Endocrinology 140 (1999) 5626-5634
27. Wilkinson R.C., and Dickson A.J. Expression of CCAAT/enhancer binding protein family genes in monolayer and sandwich culture of hepatocytes: induction of stress-inducible GADD153. Biochem. Biophys. Res. Commun. 289 5 (2001) 942-949
28. Casado M., Boscá L., and Marti{dotless}́n-Sanz P. Multiple forms of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase are expressed in perinatal rat liver. Am. J. Physiol. 270 2 Pt 1 (1996) E244-E250
29. Su T., and Waxman D.J. Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes. Arch. Biochem. Biophys. 424 2 (2004) 226-234
30. Calvo M.N., Bartrons R., Castano E., Perales J.C., Navarro-Sabate A., and Manzano A. PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells. FEBS Lett. 580 (2006) 3308-3314