6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase expression in rat brain during development

Molecular Brain Research

Volumn 75, Issue 1, 2000, Pages 138-142

  Goren, Nora ^a   Manzano, Anna ^b   Riera, Lluís ^b   Ambrosio, Santiago ^b   Ventura, Francesc ^b   Bartrons, Ramon ^b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Dept Ciencies Fisiologiques II C ^*  (Spain)

Author keywords

6 Phosphofructo 2 kinase fructose 2,6 bisphosphatase; Brain glycolysis; Gene expression

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; FRUCTOSE 2,6 BISPHOSPHATASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEMALE; FETUS; GENE EXPRESSION; GLYCOLYSIS; IMMUNOBLOTTING; MALE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGING; ANIMALS; ANIMALS, NEWBORN; BRAIN; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FRUCTOSE-BISPHOSPHATASE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GESTATIONAL AGE; MALE; MULTIENZYME COMPLEXES; PHOSPHOFRUCTOKINASE-1; PHOSPHOFRUCTOKINASE-2; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0033971932     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00319-8     Document Type: Article

References (24)

1. Ambrosio S., Ventura F., Rosa J. L, Bartrons R. Fructose 2,6-bisphosphate in hypoglycemic rat brain. J. Neurochem. 54:1991;200-203.
2. Bartrons R., Hue L., Van Schaftingen E., Hers H.G. Hormonal control of fructose 2,6-bisphosphate concentration in isolated rat hepatocytes. Biochem. J. 214:1983;829-837.
3. Burnette W.N. Western blotting: electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112:1981;195-203.
4. El-Maghrabi M.R., Correia J.J., Heil P.J., Pate T.M., Cobb C.E., Pilkis S.J. Tissue distribution, immunoreactivity, and physical properties of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Proc. Natl. Acad. Sci. U. S. A. 83(14):1986;5005-5009.
5. Foe L.G., Kemp R.G. Isozyme composition and phosphorylation of brain phosphofructokinase. Arch. Biochem. Biophys. 228:1984;503-511.
6. Gerlach W.L., Bedrook J.R. Cloning and characterization of ribosomal RNA genes from wheat and barley. Nucl. Acids Res. 7:1979;1869-1885.
7. Hamer M.J., Dickson A.J. Developmental changes in hepatic fructose 2,6-biphosphate content and phosphofructokinase-1 activity in the transition of chicks from embryonic to neonatal nutritional environment. Biochem. J. 245:1987;35-39.
8. Hamilton J.A., Callaghan M.J., Sutherland R.L., Watts C.K. Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Mol. Endocrinol. 4:1997;490-502.
9. Hue L., Rider M.H. Role of fructose-2,6-biphosphate in the control of glycolysis in mammalian tissues. Biochem. J. 245:1987;313-325.
10. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
11. Manzano A., Rosa J.L., Ventura F., Perez J.X., Nadal M., Estivill X., Ambrosio S., Gil J., Bartrons R. Molecular cloning, expression and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase gene (PFKFB3). Cytogenet. Cell Genet. 83:1998;214-217.
12. H. McIlwain, H.S. Bachelard, Biochemistry and the Central Nervous System, Churchill Livingstone, New York, 1985, pp. 392-397.
13. Pilkis S.J., Claus T.H., Kurland I.J., Lange A.J. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu. Rev. Biochem. 64:1995;799-835.
14. Rousseau G.G., Hue L. Mammalian 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a bifunctional enzyme that controls glycolysis. Prog. Nucleic Acid Res. Mol. Biol. 45:1993;99-127.
15. Sakai A., Kato M., Fukasawa M., Ishiguro M., Furuya E., Sakakibara R. Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. J. Biochem. (Tokyo). 119(3):1996;506-511.
16. Schubert Ch., Goltzsch W., Hoffman E. Perinatal changes of fructose 2,6-bisphosphate in rat liver. Biochem. Biophys. Res. Commun. 113:1983;672-677.
17. Sivitz W., De Sautel S., Walker P.S., Pessin J.E. Regulation of the glucose transporter in developing rat brain. Endocrinology. 124:1989;1875-1880.
18. Van Schaftingen E., Lederer B., Bartrons R., Hers H.G. A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate. Eur. J. Biochem. 129:1982;191-195.
19. Van Schaftingen E. Fructose 2,6-bisphosphate. Adv. Enzymol. Relat. Areas Mol. Biol. 59:1987;315-395.
20. Ventura F., Rosa J.L., Ambrosio S., Gil J., Bartrons R. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase in rat brain. Biochem. J. 276:1991;455-460.
21. Ventura F., Rosa J.L., Ambrosio S., Pilkis S.J., Bartrons R. Bovine brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Evidence for a neural-specific isozyme. J. Biol. Chem. 267(25):1992;17939-17943.
22. Ventura F., Ambrosio S., Bartrons R., El-Maghrabi M.R., Lange A.J., Pilkis S.J. Cloning and expression of a catalytic core bovine brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Biochem. Biophys. Res. Commun. 209:1995;1140-1148.
23. Watanabe F., Sakai A., Furuya E., Uyeda K. Molecular cloning and tissue specific expression of fructose 6-phosphate-2-kinase: fructose 2,6-bisphosphatase of rat brain. Biochem. Biophys. Res. Commun. 198:1994;335-340.
24. Watanabe F., Sakai A., Furuya E. Novel isoforms of rat brain fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase are generated by tissue-specific alternative splicing. J. Neurochem. 69:1997;1-9.