Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 862, Issue 1-2, 2008, Pages 51-57

  Li, Wei ^a,b   Han, Jianping ^b   Li, Zhiwen ^b   Li, Xinxin ^b   Zhou, Shuiping ^b   Liu, Changxiao ^a,c  

^a TIANJIN UNIVERSITY   (China)

^b Tianjin Tasly Group Co Ltd   (China)

^c TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

LC MS MS; Pharmacokinetic; Plasma; Pre HPLC; Silybin; Silybin A; Silybin B

Indexed keywords

CONCENTRATION (PROCESS); ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; PLASMA (HUMAN);

SILYBIN A; SILYBIN B;

BIOMOLECULES;

SILIBININ;

ARTICLE; CHEMICAL STRUCTURE; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MALE; PLASMA; PRIORITY JOURNAL; PURIFICATION; STEREOSPECIFICITY; TANDEM MASS SPECTROMETRY;

CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SILYMARIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

EID: 38649113235     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.10.040     Document Type: Article

References (17)

1. Kidd P., and Head K. Altern. Med. Rev. 10 (2005) 193
2. Kvasnicka F., Biba B., Sevcik R., Voldrich M., and Kratka J. J. Chromatogr. A 990 (2003) 239
3. Lee J.I., Hsu B.H., Wu D., and Barrett J.S. J. Chromatogr. A 1116 (2006) 57
4. Rainone F. Complement. Altern. Med. 72 (2005) 1285
5. Kren V., and Walterova D. Biomed. Pap. 149 (2005) 29
6. Barzaghi N., Crema F., Gatti G., Pifferi G., and Perucca E. Eur. J. Drug. Metab. Pharmacokinet. 15 (1990) 333
7. Morazzoni P., Magistretti M.J., Giachetti C., and Zanolo G. Eur. J. Drug. Metab. Pharmacokinet. 17 (1992) 39
8. Morazzoni P., Montalbetti A., Malandrino S., and Pifferi G. Eur. J. Drug. Metab. Pharmacokinet. 18 (1993) 289
9. Li W., Gao J., Ding N., Zhao H.Z., and Wei F. Chin. J. New Drugs 15 (2006) 817
10. Orlando R., Fragasso A., Lampertico M., and Marena C. Med. Sci. Res. 18 (1990) 861
11. Conti M., Malandrino S., and Magistretti M.J. Jpn. J. Pharmacol. 60 (1992) 315
12. Ding T.M., Tian S.J., Zhang Z.X., Gu D.Z., Chen Y.F., Shi Y.H., and Sun Z.P. J. Pharm. Biomed. 26 (2001) 155
13. Lee D.Y., and Liu Y.Z. J. Nat. Prod. 66 (2003) 1171
14. Skottova N., Svagera Z., Vecera R., Urbanek K., Jegorov A., and Simanek V. Pharmacol. Res. 44 (2001) 247
15. Xiao Y.Y., Song Y.M., Chen Z.P., and Ping Q.N. Int. J. Pharm. 307 (2006) 77
16. Li W., Gao J., Zhao H.Z., and Liu C.X. Eur. J. Drug. Metab. Pharmacokinet. 31 (2006) 265
17. Rickling B., Hans B., Kramarczyk R., Krumbiegel G., and Weyhenmeyer R. J. Chromatogr. B 670 (1995) 267