Plasma levels of P-selectin are determined by platelet turn-over and the P-selectin Thr715Pro polymorphism

Thrombosis Research

Volumn 121, Issue 4, 2008, Pages 573-579

  Panzer, Simon ^a   Rosales, Sergio ^a   Gisslinger, Heinz ^a   Jungbauer, Lea ^a   Kaider, Alexandra ^a   Knöbl, Paul ^a   Sillaber, Christian ^a   Pabinger, Ingrid ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Platelet counts; Platelet turn over; Soluble P selectin; Thr715Pro polymorphism

Indexed keywords

PADGEM PROTEIN; PROLINE; THREONINE;

ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC VARIABILITY; HUMAN; MALE; PRIORITY JOURNAL; THROMBOCYTE COUNT;

ADULT; AGED; AGED, 80 AND OVER; BLOOD PLATELETS; FEMALE; HUMANS; MALE; MIDDLE AGED; P-SELECTIN; PLATELET COUNT; POLYMORPHISM, GENETIC;

EID: 38649108508     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2007.05.025     Document Type: Article

References (28)

1. Ley K. The role of selectins in inflammation and disease. Trends Mol Med 9 (2003) 263-268
2. Wagner C.R., and Hosenpud J.D. Enhanced lymphocyte proliferative responses to donor-specific aortic endothelial cells following influenza vaccination. Transpl Immunol 1 (1993) 83-85
3. Frenette P.S., Denis C.V., Weiss L., Jurk K., Subbarao S., Kehrel B., et al. P-selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med 191 (2000) 1413-1422
4. Polgar J., Matuskova J., and Wagner D.D. The P-selectin, tissue factor, coagulation triad. J Thromb Haemost 3 (2005) 1590-1596
5. McEver R.P. Regulation of function and expression of P-selectin. Agents Actions Suppl 47 (1995) 117-119
6. Dunlop L.C., Skinner M.P., Bendall L.J., Bendall L.J., Favaloro E.J., Castaldi P.A., et al. Characterization of GMP-140 (P-selectin) as a circulating plasma protein. J Exp Med 175 (1992) 1147-1150
7. Berger G., Hartwell D.W., and Wagner D.D. P-selectin and platelet clearance. Blood 92 (1998) 4446-4452
8. Mehta P., Patel K.D., Laue T.M., Erickson H.P., and McEver R.P. Soluble monomeric P-selectin containing only the lectin and epidermal growth factor domains binds to P-selectin glycoprotein ligand-1 on leukocytes. Blood 90 (1997) 2381-2389
9. Jilma B., Eichler H.G., Vondrovec B., Breiteneder H., Kyrle P.A., Kitzweger E., et al. Effects of desmopressin on circulating P-selectin. Br J Haematol 93 (1996) 432-436
10. Jilma B., Fasching P., Ruthner C., Rumplmayr A., Ruzicka S., Kapiotis S., et al. Elevated circulating P-selectin in insulin dependent diabetes mellitus. Thromb Haemost (1996) 328-332
11. Blann A.D., and Lip G.Y. Hypothesis: is soluble P-selectin a new marker of platelet activation?. Atherosclerosis (1997) 135-138
12. Fijnheer R., Frijns C.J., Korteweg J., Rommes H., Peters J.H., Sixma J.J., et al. The origin of P-selectin as a circulating plasma protein. Thromb Haemost (1997) 1081-1085
13. Joseph J.E., Harrison P., Mackie I.J., Isenberg D.A., and Machin S.J. Increased circulating platelet-leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis. Br J Haematol 115 (2001) 451-459
14. Andre P., Hartwell D., Hrachovinova I., Saffaripour S., and Wagner D.D. Procoagulant state resulting from high levels of soluble P-selectin in blood. Proc Natl Acad Sci U S A 97 (2000) 13835-13840
15. Guray U., Erbay A.R., Guray Y., Yilmaz M.B., Boyaci A.A., Sasmaz H., et al. Levels of soluble adhesion molecules in various clinical presentations of coronary atherosclerosis. Int J Cardiol 96 (2004) 235-240
16. Ikeda H., Nakayama H., Oda T., Kuwano K., Muraishi A., Sugi K., et al. Soluble form of P-selectin in patients with acute myocardial infarction. Coron Artery Dis (1994) 515-518
17. Chong B.H., Murray B., Berndt M.C., Dunlop L.C., Brighton T., and Chesterman C.N. Plasma P-selectin is increased in thrombotic consumptive platelet disorders. Blood (1994) 1535-1541
18. Miller M.A., Kerry S.M., Dong Y., Strazzullo P., and Cappuccio F.P. Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London. Thromb Haemost 92 (2004) 1060-1065
19. Barbaux S.C., Blankenberg S., Rupprecht H.J., Francomme C., Bickel C., Hafner G., et al. Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease. Arterioscler Thromb Vasc Biol 21 (2001) 1668-1673
20. Ferrari J., Rieger S., Endler G., Greisenegger S., Funk M., Scholze T., et al. The Thr715Pro polymorphism of the P-selectin gene is not associated with ischemic stroke risk. Stroke 38 (2007) 395-397
21. Blann A.D., Daly R.J., and Amiral J. The influence of age, gender and ABO blood group on soluble endothelial cell markers and adhesion molecules. Br J Haematol 92 (1996) 498-500
22. Fuchs I., Frossard M., Spiel A., Riedmuller E., Laggner A.N., and Jilma B. Platelet function in patients with acute coronary syndrome (ACS) predicts recurrent ACS. J Thromb Haemost 4 (2006) 2547-2552
23. Linden M.D., Furman M.I., Frelinger III A.L., Fox M.L., Barnard M.R., Li Y., et al. Indices of platelet activation and the stability of coronary artery disease. J Thromb Haemost 5 (2007) 761-765
24. Ay C., Jungbauer L.V., Sailer T., Tengler T., Koder S., Kaider A., et al. High concentrations of soluble P-Selectin are associated with risk of venous thromboembolism and the P-Selectin Thr715 variant. Clin Chem 53 (2007) 1235-1243
25. Scheithauer W., Gisslinger H., Temsch E.M., Linkesch M., Linkesch W., and Ludwig H. Effect of recombinant interferon-alpha2C on reticuloendothelial function in patients with thrombocytosis. J Interferon Res 10 (1990) 237-242
26. Dole V.S., Bergmeier W., Mitchell H.A., Eichenberger S.C., and Wagner D.D. Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Blood 106 (2005) 2334-2339
27. Herrmann S.M., Ricard S., Nicaud V., Mallet C., Evans A., Ruidavets J.-B., et al. The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction. Hum Mol Genet 7 (1998) 1277-1284
28. Bugert P., Pabinger I., Stamer K., Vormittag R., Skeate R.C., Wahi M.M., et al. The risk for thromboembolic disease in lupus anticoagulant patients due to pathways involving P-selectin and CD154. Thromb Haemost 97 (2007) 573-580