The Thr715Pro polymorphism of the P-selectin gene is not associated with ischemic stroke risk

Stroke

Volumn 38, Issue 2, 2007, Pages 395-397

  Ferrari, Julia ^a   Rieger, Sandra ^b   Endler, Georg ^b   Greisenegger, Stefan ^b   Funk, Marion ^b   Scholze, Thomas ^b   Lang, Wilfried ^a,b   Lalouschek, Wolfgang ^a,b   Mannhalter, Christine ^b  

^a KRANKENHAUS DER BARMHERZIGEN BRÜDER   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Genetics; Stroke

Indexed keywords

PADGEM PROTEIN;

ADULT; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENDER; HUMAN; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RISK; TRANSIENT ISCHEMIC ATTACK; VASCULAR DISEASE;

ALLELES; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; COHORT STUDIES; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; P-SELECTIN; POLYMORPHISM, GENETIC; PREVALENCE; PROLINE; REGISTRIES; RISK FACTORS; THREONINE;

EID: 33846572843     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000254475.43533.dd     Document Type: Article

References (13)

1. Watson ML, Kingsmore SF, Johnston GI, Siegelman MH, Le Beau MM, Lemons RS, Bora NS, Howard TA, Weissman IL, McEver RP. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. J Exp Med. 1990;172:263-272.
2. Frenette PS, Johnson RC, Hynes RO, Wagner DD. Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc Natl Acad Sci U S A. 1995;92:7450-7454.
3. Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 1993;74:541-554.
4. Johnson RC, Mayadas TN, Frenette PS, Mebius RE, Subramaniam M, Lacasce A, Hynes RO, Wagner DD. Blood cell dynamics in P-selectin-deficient mice. Blood. 1995;86:1106-1114.
5. Kunzendorf U, Notter M, Hock H, Distler A, Diamantstein T, Walz G.T. cells bind to the endothelial adhesion molecule GMP-140 (P-selectin). Transplantation. 1993;56:1213-1217.
6. Herrmann SM, Ricard S, Nicaud V, Mallet C, Evans A, Ruidavets JB, Arveiler D, Luc G, Cambien F. The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction. Hum Mol Genet. 1998;7:1277-1284.
7. Volcik KA, Ballantyne CM, Coresh J, Folsom AR, Wu KK, Boerwinkle E. P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke The Atherosclerosis Risk In Communities Study. Atherosclerosis. 2006;186:74-79.
8. Lang W, Lalouschek W for the Vienna Stroke Study Group. The Vienna stroke registry-objectives and methodology. Wien Klin Wochenschr. 2001;113:141-147.
9. Lalouschek W, Lang W, Muellner M. Current strategies of secondary prevention after a cerebrovascular event: The Vienna stroke registry. Stroke. 2001;32:2860-2866.
10. Sunder-Plassmann R, Rieger S, Endler G, Brunner M, Muller M, Mannhalter C. Simultaneous analysis of MDR1 C3435T, G2677T/A, and C1236T genotypes by multiplexed mutagenically separated PCR. Clin Chem Lab Med. 2005;43:192-194.
11. Schlesselman JJ. Sample Size Requirements in Cohort and Case-Control Studies of Disease. Am J Epidemiol. 1974;99:381-384.
12. Barbaux SC, Blankenberg S, Rupprecht HJ, Francomme C, Bickel C, Hafner G, Nicaud V, Meyer J, Cambien F, Tiret L. Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery disease. Arterioscler Thromb Vasc Biol. 2001;21:1668-1673.
13. Kee F, Morrisson C, Evans AE, McCrum E, McMaster D, Dallongeville J, Nicaud V, Poirier O, Cambien F. Polymorphisms of the P-selectin gene and risk of myocardial infarction in men and women in the ECTIM extension study. Heart. 2000;84:548-552.