Long-term L-DOPA treatment causes indiscriminate increase in dopamine levels at the cost of serotonin synthesis in discrete brain regions of rats

Cellular and Molecular Neurobiology

Volumn 27, Issue 8, 2007, Pages 985-996

  Borah, Anupom ^a   Mohanakumar, Kochupurackal P ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Dopamine and serotonin synthesis; Forced swim test; Motor behavior; Nucleus raphe; Parkinson's disease

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; CARBIDOPA; DOPAMINE; HOMOVANILLIC ACID; LEVODOPA; NORADRENALIN; SEROTONIN; SYNDOPA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; BRAIN REGION; CONFERENCE PAPER; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINE METABOLISM; DRUG BRAIN LEVEL; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOTOR ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEROTONIN METABOLISM; STEADY STATE;

ANIMALS; BRAIN; DEPRESSION; DOPAMINE; LEVODOPA; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SWIMMING; TIME FACTORS;

ANIMALIA; PARKINSONIA; RATTUS;

EID: 38649101598     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-007-9213-6     Document Type: Conference Paper

References (43)

1. Adell A, Celada P, Artigas F (2001) The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain. J Neurochem 79:172-182
2. Ahlskog JE, Muenter MD (2001) Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord 16:448-458
3. Arai R, Karasawa N, Geffard M, Nagatsu T, Nagatsu I (1994) Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase. Brain Res 667:295-299
4. Arai R, Karasawa N, Geffard M, Nagatsu I (1995) L-DOPA is converted to dopamine in serotonergic fibers of the striatum of the rat. A double-labeling immunofluorescence study. Neurosci Lett 195:195-198
5. Arai R, Karasawa N, Nagatsu I (1996) Aromatic l-amino acid decarboxylase is present in serotonergic fibers of the striatum of the rat. A double-labeling immunofluorescence study. Brain Res 706:177-179
6. 1A receptor stimulation. Eur J Neurosci 23:2669-2676
7. Brown WD, Taylor MD, Roberts AD, Oakes TR, Schueller MJ, Holden JE, Malischke LM, DeJesus OT, Nickles RJ (1999) Fluorodopa PET shows the nondopaminergic as well as dopaminergic destinations of levodopa. Neurology 53:1212-1218
8. Carlsson A (1993) Thirty years of dopamine research. Adv Neurol 60:1-10
9. Cenci MA (2007) Dopamine dysregulation of movement control in L-DOPA-induced dyskinesia. Trends Neurosci 30:236-243
10. Chandra G, Gangopadhyay PK, Senthil Kumar KS, Mohanakumar KP (2006) Acute intranigral homocysteine administration produces stereotypic behavioral changes and striatal dopamine depletion in Sprague-Dawley rats. Brain Res 1075:81-92
11. Chase TN (1998) Levodopa therapy: consequences of the nonphysiologic replacement of dopamine. Neurology 50:S17-S25
12. Chesselet MF, Delfs JM (1996) Basal ganglia and movement disorders: an update. Trends Neurosci 19:417-422
13. Christenson JG, Dairman W, Udenfriend S (1970) Preparation and properties of a homogeneous aromatic L-amino acid decarboxylase from hog kidney. Arch Biochem Biophys 141:356-367
14. Cummings JL, Masterman DL (1999) Depression in patients with Parkinson's disease. Int J Geriatr Psychiatry 14:711-718
15. Guerra MJ, Liste I, Labandeira-Garcia JL (1998) Interaction between the serotonergic, dopaminergic, and glutamatergic systems in fenfluramine-induced Fos expression in striatal neurons. Synapse 28:71-82
16. Hefti F, Melamed E, Wurtman RJ (1981) The site of dopamine formation in rat striatum after l-DOPA administration. J Pharmacol Exp Ther 217:189-197
17. Hornykiewicz O (1998) Biochemical aspects of Parkinson's disease. Neurology 51:S2-S9
18. Hui JS, Murdock GA, Chung JS, Lew MF (2005) Behavioral changes as side effects of medication treatment for Parkinson's disease. Adv Neurol 96:114-129
19. Jaeger CB, Teitelman G, Joh TH, Albert VR, Park DH, Reis DJ (1983) Some neurons of the rat central nervous system contain aromatic L-amino acid decarboxylase but not monoamines. Science 219:1233-1235
20. Kannari K, Tanaka H, Maeda T, Tomiyama M, Suda T, Matsunaga M (2000) Reserpine pretreatment prevents increases in extracellular striatal dopamine following l-DOPA administration in rats with nigrostriatal denervation. J Neurochem 74:263-269
21. Kannari K, Shen H, Arai A, Tomiyama M, Baba M (2006) Reuptake of l-DOPA-derived extracellular dopamine in the striatum with dopaminergic denervation via serotonin transporters. Neurosci Lett 402:62-65
22. Klapdor K, Dulfer BG, Hammann A, Van der Staay FJ (1997) A low-cost method to analyse footprint patterns. J Neurosci Methods 75:49-54
23. 1B receptors. J Pharmacol Exp Ther 292:1111-1117
24. Kostic VS, Djuricic BM, Covickovic-Sternic N, Bumbasirevic L, Nikolic M, Mrsulja BB (1987) Depression and Parkinson's disease: possible role of serotonergic mechanisms. J Neurol 234:94-96
25. Lavoie B, Parent A (1990) Immunohistochemical study of the serotoninergic innervation of the basal ganglia in the squirrel monkey. J Comp Neurol 299:1-16
26. Leentjens AF (2004) Depression in Parkinson's disease: conceptual issues and clinical challenges. J Geriatr Psychiatry Neurol 17:120-126
27. Lemke MR, Fuchs G, Gemende I, Herting B, Oehlwein C, Reichmann H, Reike J, Volkmann J (2004) Depression and Parkinson's disease. J Neurol 6:24-27
28. Lopez A, Munoz A, Guerra MJ, Labandeira-Garcia JL (2001) Mechanisms of the effects of exogenous levodopa on the dopamine denervated-striatum. Neuroscience 103:639-651
29. Lovenberg W, Weissbach H, Udenfriend S (1962) Aromatic L-amino acid decarboxylase. J Biol Chem 237:89-93
30. Maeda T, Nagata K, Yoshida Y, Kannari K (2005) Serotonergic hyperinnervation into the dopaminergic-denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA. Brain Res 1046:230-233
31. Mazzella L, Yahr MD, Marinelli L, Huang N, Moshier E, Di Rocco A (2005) Dyskinesias predict the onset of motor response fluctuations in patients with Parkinson's disease on l-DOPA monotherapy. Parkinsonism Relat Disord 11:151-155
32. Mehta H, Saravanan KS, Mohanakumar KP (2003) Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice. Behav Brain Res 145:31-36
33. Meissner W, Ravenscroft P, Reese R, Harnack D, Morgenstern R, Kupsch A, Klitgaard H, Bioulac B, Gross CE, Bezard E, Boraud T (2006) Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine. Neurobiol Dis 22:586-598
34. Miller D, Abercrombie ED (1999) Role of high-affinity dopamine uptake and impulse activity in the appearance of extracellular dopamine in striatum after administration of exogenous L-DOPA: studies in intact and 6-hydroxydopamine- treated rats. J Neurochem 72:1516-1522
35. Mura A, Jackson D, Manley MS, Young SJ, Groves PM (1995) Aromatic L-amino acid decarboxylase immunoreactive cells in the rat striatum: a possible site for the conversion of exogenous L-DOPA to dopamine. Brain Res 704:51-60
36. Muralikrishnan D, Mohanakumar KP (1998) Neuroprotection by bromocriptine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. FASEB J 12:905-912
37. Nicholson SL, Brotchie JM (2002) 5-hydroxytryptamine (5-HT, serotonin) and Parkinson's disease-opportunities for novel therapeutics to reduce the problems of levodopa therapy. Eur J Neurol 9:1-6
38. Nutt JG (1990) Levodopa-induced dyskinesia: review, observations, and speculations. Neurology 40:340-345
39. Palkovits M, Brownstein MJ (1983) Brain microdissection techniques. John Wiley and Sons, New York
40. Poewe W (2003) Psychosis in Parkinson's disease. Mov Disord 6:S80-S87
41. Porsolt RD, Pichon LM, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730-732
42. Rozas G, Liste I, Guerra MJ, Labandeira-Garcia JL (1998) Sprouting of the serotonergic afferents into striatum after selective lesion of the dopaminergic system by MPTP in adult mice. Neurosci Lett 245:151-154
43. Steinbusch HWM (1984) Serotonin-immunoreactive neurons and their projections in the CNS. In: Bjorklund A, Hokfelt T, Kuhar MJ (eds) Handbook of chemical neuroanatomy, vol. 3, classical transmitter receptors in the CNS, part II. Elsevier Sciences Publishers, Amsterdam, pp. 68-125