A simple and fast method for quantification of ertapenem using meropenem as internal standard in human plasma in a clinical setting

Therapeutic Drug Monitoring

Volumn 30, Issue 1, 2008, Pages 90-94

  D'Avolio, Antonio ^a,b   Baietto, Lorena ^a   De Rosa, Francesco Giuseppe ^a   Garazzino, Silvia ^a   Sciandra, Mauro ^a   Siccardi, Marco ^a   Bonora, Stefano ^a   Perri, Giovanni Di ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b AMEDEO DI SAVOIA HOSPITAL   (Italy)

Author keywords

Ertapenem; HPLC UV; Human plasma; Meropenem; TDM

Indexed keywords

ERTAPENEM; MEROPENEM;

ACCURACY; ARTICLE; BLOOD SAMPLING; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG RESEARCH; DRUG RETENTION; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; ULTRAVIOLET RADIATION;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; THIENAMYCINS; ULTRAVIOLET RAYS;

EID: 38549173170     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/FTD.0b013e31815f4f7e     Document Type: Article

References (25)

1. Barboza E, Solomkin J, Goldstein EJ, et al. New Beta-lactam agent in the treatment of intra-abdominal sepsis: double blind and randomized stage III study of ertapenem versus piperacillin/tazobactam. Rev Gastroenterol Peru. 2003;23:192-198.
2. Brink AJ, Feldman C, Grolman DC, et al. Appropriate use of the carbapenems. S Afr Med J. 2004;94:857-861.
3. Graham DR, Lucasti C, Malafaia O, et al. Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study. Clin Infect Dis. 2002;34:1460-1468.
4. Musson DG, Majumdar A, Birk K, et al. Pharmacokinetics of intramuscularly administered ertapenem. Antimicrob Agents Chemother. 2003;47:1732-1735.
5. Deryke CA, Banevicius MA, Fan HW, et al. Evaluation of the bactericidal activity of meropenem and ertapenem against extended-spectrum beta-lactamase producing Escherichia coli and klebsiella pneumoniae in a neutropenic mouse thigh model. Antimicrob Agents Chemother. 2007;51:1481-1486.
6. Moczygemba LR, Frei CR, Burgess DS. Pharmacodynamic modeling of carbapenems and fluoroquinolones against bacteria that produce extended-spectrum beta-lactamases. Clin Ther. 2004;26:1800-1807.
7. Majumdar AK, Musson DG, Birk KL, et al. Pharmacokinetics of ertapenem in healthy young volunteers. Antimicrob Agents Chemother. 2002;46:3506-3511.
8. Drusano GL. Antimicrobial pharmacodynamics: critical interactions of 'bug and drug.' Nat Rev Microbiol. 2004;2:289-300.
9. Chen M, Nafziger AN, Drusano GL, et al. Comparative pharmacokinetics and pharmacodynamic target attainment of ertapenem in normal-weight, obese, and extremely obese adults. Antimicrob Agents Chemother. 2006;50:1222-1227.
10. Mistry GC, Majumdar AK, Swan S, et al. Pharmacokinetics of ertapenem in patients with varying degrees of renal insufficiency and in patients on hemodialysis. J Clin Pharmacol. 2006;46:1128-1138.
11. Hedberg M, Nord CE. Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe. Clin Microbiol Infect. 2003;9:475-488.
12. Papaparaskevas J, Pantazatou A, Katsandri A, et al. Multicentre survey of the in-vitro activity of seven antimicrobial agents, including ertapenem, against recently isolated Gram-negative anaerobic bacteria in Greece. Clin Microbiol Infect. 2005;11:820-824.
13. Gordien JB, Boselli E, Fleureau C, et al. Determination of free ertapenem in plasma and bronchoalveolar lavage by high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;830:218-223.
14. Musson DG, Birk KL, Cairns AM, et al. High-performance liquid chromatographic methods for the determination of a new carbapenem antibiotic, L-749,345, in human plasma and urine. J Chromatogr B Biomed Sci Appl. 1998;720:99-106.
15. Koal T, Deters M, Resch K, et al. Quantification of the carbapenem antibiotic ertapenem in human plasma by a validated liquid chromatography-mass spectrometry method. Clin Chim Acta. 2006;364:239-245.
16. Jaruratanasirikul S, Sriwiriyajan S. Stability of meropenem in normal saline solution after storage at room temperature. Southeast Asian J Trop Med Public Health. 2003;34:627-629.
17. Mendez AS, Steppe M, Schapoval EE. Validation of HPLC and UV spectrophotometric methods for the determination of meropenem in pharmaceutical dosage form. J Pharm Biomed Anal. 2003;33:947-954.
18. Soltani M, MacGowan AP, Lovering AM. Assay of ertapenem in human serum by high-performance liquid chromatography. Int J Antimicrob Agents. 2006;27:165-167.
19. Center for Drug Evaluation and Research of the U.S. Department of Health and Human Services Food and Drug Administration. Guidance for Industry Bioanalytical Method Validation [FDA web site], May 2001. Available at: http://www.fda.gov/cder/guidance/4252fnl.htm. Accessed March 20, 2007.
20. Peter FT, Maurer HH. Bioanalytical method validation and its implications for forensic and clinical toxicology: a review. Qual Assur. 2002;7:441-449.
21. Mundkowski RG, Majcher-Peszynska J, Burkhardt O, et al. A new simple HPLC assay for the quantification of ertapenem in human plasma, lung tissue, and broncho-alveolar lavage fluid. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;832:231-235.
22. Kitchen CJ, Musson DG, Fisher AL. Column-switching technique for the sensitive determination of ertapenem in human cerebrospinal fluid using liquid chromatography and ultraviolet absorbance detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;799:9-14.
23. Musson DG, Kitchen CJ, Hsieh JY, et al. Modified high-performance liquid chromatographic method for the determination of ertapenem in human urine: enhanced selectivity and automation. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;779:341-346.
24. Musson DG, Birk KL, Kitchen CJ, et al. Assay methodology for the quantitation of unbound ertapenem, a new carbapenem antibiotic, in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;783:1-9.
25. Burkhardt O, Kumar V, Katterwe D, et al. Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration. J Antimicrob Chemother. 2007;59:277-284.